Protein

Protein accession
A0A8S5Q3J9 [UniProt]
Representative
6i0U6
Source
UniProt (cluster: phalp2_28988)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MPWNYKGWHCGKGNKGSANNTHVSVELCEDALTDATYFNKVYKEAVEFAAYLCQLYNFDPLKDGVIIGHYEGHQRGIASNHADPRNWFPRFGKSMDTFRQDVAAKMGKRVTPTTHTNTETTVSYSGIVTASVLRIRKGPSVSSSIAGTLKKGEGVSVILEDNGWGKLADGSGWVSLTYVKKNAAPANTFKSYKGKITATSGVNIRIGAGTNYNKNGALAYNSVVAIVDEKKVSGITWGKLADGRGWISLAYLKKI
Physico‐chemical
properties
protein length:255 AA
molecular weight:27708,1 Da
isoelectric point:9,56
hydropathy:-0,36
Representative Protein Details
Accession
6i0U6
Protein name
6i0U6
Sequence length
161 AA
Molecular weight
16872,14490 Da
Isoelectric point
10,26409
Sequence
MDTFRADVAAKMGKKVTPTTPINTGTTVSYSGVVTASVLRIRKGPSVSSSVAGTLKKGTGVSIILEDNGWGKLADGSGWVSLTYIKKNSTPTSTFKSYRGKITASSGVNIRTGAGTNYSKNGALTYNSVVTIVSEKKVSGITWGKLADGRGWISLAYLKKI
Other Proteins in cluster: phalp2_28988
Total (incl. this protein): 5 Avg length: 181,0 Avg pI: 9,91
Protein ID Length (AA) pI
6i0U6 161 10,26409
4ympq 167 9,41627
5TKC1 161 10,18480
60dNF 161 10,11633
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37390
2c00b
 2 40,0% 140 1.202E-31
2 phalp2_230
60Bse
 3 38,1% 152 1.861E-23
3 phalp2_30751
7Bn1l
 73 33,5% 164 7.890E-19
4 phalp2_27054
2dgKz
 1 32,5% 160 8.579E-17
5 phalp2_20981
7wHXN
 28 37,0% 124 4.086E-16

Domains

Domains [InterPro]
Disordered region
SH3_3
SH3_3
Representative sequence (used for alignment): 6i0U6 (161 AA)
Member sequence: A0A8S5Q3J9 (255 AA)
1 161 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctLqe90
[NCBI] 		2825456 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015564 [NCBI]
CDS location
range 156783 -> 157550
strand -
CDS
TTGCCTTGGAATTATAAAGGCTGGCATTGTGGAAAGGGAAACAAAGGTAGCGCTAATAATACCCACGTCTCGGTGGAATTGTGTGAGGATGCGCTGACAGATGCTACTTATTTTAATAAAGTATATAAAGAGGCTGTTGAGTTCGCAGCTTATCTTTGCCAGCTTTACAATTTCGACCCATTAAAAGATGGAGTAATTATTGGACATTATGAAGGACACCAAAGAGGTATCGCTTCTAATCATGCTGACCCTCGTAATTGGTTTCCCCGTTTTGGCAAGAGTATGGACACTTTTAGACAAGATGTTGCTGCTAAGATGGGTAAAAGGGTAACTCCTACTACCCACACTAATACTGAAACTACTGTGTCTTATTCTGGTATTGTCACCGCTTCTGTTTTGAGAATTCGTAAAGGTCCTTCTGTTTCTTCTTCTATTGCTGGAACTCTTAAAAAGGGCGAAGGTGTTTCTGTTATTCTTGAAGATAATGGTTGGGGTAAATTGGCGGATGGTAGTGGTTGGGTAAGTTTAACTTATGTCAAAAAGAATGCTGCTCCAGCTAATACTTTTAAGAGTTATAAAGGTAAAATTACAGCAACTTCTGGCGTTAATATAAGAATTGGTGCTGGTACTAATTATAATAAAAATGGAGCTTTGGCTTATAATTCAGTTGTAGCTATTGTCGATGAGAAAAAAGTCTCTGGTATAACTTGGGGTAAGTTAGCCGATGGTAGAGGTTGGATTAGCCTTGCTTATTTGAAAAAGATTTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6i0U6) rather than this protein.
PDB ID
6i0U6
Method AlphaFoldv2
Resolution 79.75
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50