Protein

Protein accession
A0A8S5PZ25 [UniProt]
Representative
5X5xO
Source
UniProt (cluster: phalp2_6199)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKISIIDISQHNEIVNFNTLKKHCEGVIIRAGYKGYGTGRNTTDTMFIRNITCAIKSGLKYIGVYWLSQSVTTAEAKSEANYLVNILKPYKSRINFPVYIDSEWSNNKHNGRADGLTKNARTAITTVFLDTIKNAGYTAGIYASTSWYSDKLDDSKLKKYTHWVADYRGRNGYGKSDGWQYTEKYNINGNLFDRSEFYTDFKKSAPAPTKTSTSFKQGQAVKLTKANLYASQDSTKPARQLTGTYYIYDGKLMHLGRYRITSKPEYCGKGTTYITGYVAYTNFK
Physico‐chemical
properties
protein length:284 AA
molecular weight:32214,0 Da
isoelectric point:9,61
hydropathy:-0,63
Representative Protein Details
Accession
5X5xO
Protein name
5X5xO
Sequence length
253 AA
Molecular weight
28920,54550 Da
Isoelectric point
8,90381
Sequence
MELKGLDLSKYQKGIDFNAIKNAGYKFVILRVGIRGYKYSNITKDECFESFYKQAKVNGLGVGAYFFTQATNDVEALDEANFVTEAIKGKVFEYPIYIDTEYSNNAHNGRADNISKATRTSVCKTFCDTLERRGYYAGIYCSESWLSSKLNYNELRKYDKWIAKWSSIKPYTLYGTYGMWQNSNAVHIGGIRCDGNIRFYDYPAIMIDKCLNGFKTPVKKYRVTVNNITNGDKELIVNVTKSLSLKEVTVEEV
Other Proteins in cluster: phalp2_6199
Total (incl. this protein): 102 Avg length: 263,8 Avg pI: 7,38
Protein ID Length (AA) pI
5X5xO 253 8,90381
10zAf 292 8,99516
13FcA 264 8,70828
149eS 268 6,62188
1511U 269 8,74225
23zCV 333 8,84405
2fXlS 267 8,41662
3TFA3 263 8,13225
3WHiO 268 8,59294
3WKCI 206 8,27137
3ZDO5 269 5,98716
3ZGmS 238 8,68939
3ZVMq 277 4,86322
3d5uk 268 8,09950
3gczf 268 8,72130
3mgpr 256 5,13139
3vD67 274 9,23279
3vNPU 256 5,82005
4LdOU 268 5,83233
4f9eM 253 7,50527
4xwkl 302 5,36926
5K0cm 267 8,01576
5K8Tc 274 9,41827
5KQtZ 280 9,45882
5Knoe 274 9,26825
5LHML 274 9,22512
5LkKU 255 6,89010
5NZA0 256 5,13139
5O3L2 280 9,45882
5ORvo 256 5,13139
5Os3q 272 9,28379
5PeGN 251 6,01825
5Py28 256 5,13310
5PyKZ 256 4,97952
5QNOE 275 9,21751
5R7e0 256 5,12451
5Rb3u 272 9,29997
5SZwQ 252 7,51772
5Seze 256 5,05596
5VK0a 274 9,31576
5VlcW 280 9,49776
5XiQd 274 9,26825
5YEEc 256 5,13139
5ZJVU 275 9,37855
60dSZ 256 5,13139
60wCM 274 9,31576
60wDD 256 5,53762
61DNI 256 5,70990
62XwG 274 9,30796
63KbW 253 8,97079
649Gy 256 5,04750
64s2a 274 9,27599
65WSb 256 5,19971
66vhl 256 5,13139
67BdY 256 5,13139
67EkQ 274 9,26825
67Uqv 273 4,94831
67cfB 275 9,26825
6ZvEC 272 9,22499
6aEsx 256 5,13139
6apDZ 274 9,28385
6bchK 274 9,30796
6dWxn 251 6,01825
6h4Rz 275 9,30803
6jEWk 272 9,24040
6lHzl 280 9,48880
6maOd 274 9,36057
6mz9n 274 9,35244
6nKP2 251 5,30640
6nkNE 257 8,94255
6o8jE 274 9,25149
6rh3G 256 5,27093
6srnl 274 9,20056
6v71W 255 5,19886
6wABz 256 5,12281
7Vo9L 256 5,21790
7WCU0 250 8,07436
7Wjgi 250 5,98795
7XuHw 256 5,05466
7YxRz 256 5,29719
7YxhJ 230 4,40749
7ZKn1 303 6,99946
83V9G 275 9,26825
87zEw 256 5,65061
8bfzR 237 5,70234
8brU6 234 6,43852
8bsMs 248 9,32646
8dlju 251 8,35493
8f6ux 256 5,82448
8fAh4 268 5,14179
8kQPB 251 5,86484
8kVRR 256 5,31475
8klOb 251 5,30640
8m390 256 5,65061
8oP3f 272 9,29997
8pLcV 250 8,07874
8rlcX 256 5,54160
8tSKT 248 7,52920
8vK0a 274 9,31583
ZvW8 252 7,52221
A0A8S5U284 284 9,65474
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3425
3TK4D
 923 44,4% 218 4.623E-91
2 phalp2_31512
3WNwM
 280 42,2% 225 1.243E-81
3 phalp2_529
o3Q8
 73 41,2% 240 1.259E-78
4 phalp2_26548
858CP
 728 37,7% 212 4.428E-78
5 phalp2_29740
1rkWk
 100 40,4% 198 1.958E-70
6 phalp2_15044
7hFHn
 33 35,9% 220 4.549E-66
7 phalp2_5668
4yhqW
 7 38,6% 189 1.051E-64
8 phalp2_15589
2brBA
 13 29,1% 261 5.054E-64
9 phalp2_33310
6kV0o
 68 31,6% 202 2.429E-63
10 phalp2_24035
8aWkT
 56 34,2% 210 3.325E-63

Domains

Domains [InterPro]
GH25
Representative sequence (used for alignment): 5X5xO (253 AA)
Member sequence: A0A8S5PZ25 (284 AA)
1 253 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctQYc56
[NCBI] 		2825100 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015547 [NCBI]
CDS location
range 17486 -> 18340
strand +
CDS
ATGAAAATATCAATAATCGACATATCACAGCATAATGAAATAGTAAATTTTAACACGTTGAAAAAACATTGCGAGGGTGTTATAATCCGTGCAGGATATAAAGGATATGGTACAGGCAGAAACACCACTGACACAATGTTTATACGCAATATTACTTGTGCGATTAAATCAGGTTTAAAATACATCGGCGTGTATTGGCTCTCACAAAGCGTTACAACAGCAGAGGCAAAAAGCGAAGCAAATTATCTTGTAAATATTTTAAAGCCATACAAGAGCCGTATAAACTTCCCTGTTTATATCGACAGCGAATGGAGCAATAACAAACACAATGGCAGAGCTGACGGACTTACAAAAAACGCAAGAACCGCCATAACAACGGTTTTTCTTGACACAATCAAAAACGCAGGTTATACCGCAGGGATATATGCATCAACATCGTGGTATTCTGACAAACTTGATGATTCAAAGCTTAAAAAATATACTCATTGGGTCGCAGATTACAGAGGAAGAAACGGTTACGGCAAGTCGGACGGCTGGCAATACACAGAAAAATATAATATAAACGGCAATTTATTCGACAGGTCAGAATTTTATACAGATTTTAAAAAGTCAGCTCCTGCACCGACAAAAACATCAACAAGTTTTAAGCAGGGACAGGCTGTAAAACTCACAAAAGCAAATCTCTATGCATCGCAGGACAGCACAAAGCCTGCAAGACAGCTTACAGGCACATATTACATATATGACGGCAAACTTATGCACCTCGGACGTTACCGCATTACCTCAAAGCCTGAATACTGTGGCAAGGGTACAACTTATATCACAGGGTATGTTGCTTATACTAATTTTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5X5xO) rather than this protein.
PDB ID
5X5xO
Method AlphaFoldv2
Resolution 94.70
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50