Protein

Protein accession
A0A8S5PXC9 [UniProt]
Representative
3k10b
Source
UniProt (cluster: phalp2_31693)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 90% (predicted by ML model)
Protein sequence
MLFYHFDCCFTQFVGVHKSNIRNMCILTNLEQKRSVSIMSTYQFDDKTQLSAHFNVQEFKCQCGKSHDILIDSGLIDKLERLYTALNCSKIIVTSGYRCPEHDKAVGGTSSGQHTKGTAADVCCYGQDGQPISSKTVCCKAQDLGFGGIANITSSYQYTHLDVRTGYRWLGDEVKGNGTVTEDFYKYFGIKKAAETTSVLKGIDVSYCQNEVDWDAAKASGLVDFAILRAGYGREPNQVDTQFNRNYAACKRLGIPCGAYWFSYAMSADEARREAQVFLQTIKGKSFEYPVYMDLENEKQFALGKSACSAIVDAFLSVLEQSGYYAGLYCSTYYLDNYLSDSIKSRYTVWCAQYASKCTYQNPYGIWQYNVAGNVEYDIIGQKSIPGIVGECDMDYCYTDYPAIIKAAGLNGFTKTTQPTESEPDTEESTLQQILKHVASLDAKL
Physico‐chemical
properties
protein length:445 AA
molecular weight:49685,4 Da
isoelectric point:5,58
hydropathy:-0,31
Representative Protein Details
Accession
3k10b
Protein name
3k10b
Sequence length
194 AA
Molecular weight
22343,34300 Da
Isoelectric point
8,32469
Sequence
LRFVCHFFAFCLAGYSGAYWFSYAMSADEAKREAQVFLQTIKGKLFEYPVYMDLELAKQFALGKAACSEMADAFLSTMEQAGYYAGLYCSTYYLDKYLSDSVKSRYTIWCAQYASKCTYQNPYGIWQYNVAGSTEHDIIGQKSIPGIVGECDMDYCYTDYPSIIKAAGLELVFIAKKWYNRRYEKRISSNKLRK
Other Proteins in cluster: phalp2_31693
Total (incl. this protein): 2 Avg length: 319,5 Avg pI: 6,95
Protein ID Length (AA) pI
3k10b 194 8,32469
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11218
6q99m
 1 36,0% 122 3.840E-22
2 phalp2_22731
85jlZ
 4 37,5% 157 2.484E-21
3 phalp2_22083
5Px4Y
 13 40,0% 130 6.313E-21
4 phalp2_11208
6hYV2
 1315 33,9% 156 1.604E-20
5 phalp2_4905
61NJ0
 1 36,5% 123 2.009E-17
6 phalp2_5668
4yhqW
 7 37,3% 123 4.494E-14
7 phalp2_12595
1nZVJ
 1 31,8% 138 1.536E-13
8 phalp2_38591
21A2U
 2 32,1% 143 2.838E-13
9 phalp2_24174
2ojoF
 57 29,7% 158 2.359E-10
10 phalp2_6721
21tVf
 5 27,3% 146 1.459E-09

Domains

Domains [InterPro]
GH25
Representative sequence (used for alignment): 3k10b (194 AA)
Member sequence: A0A8S5PXC9 (445 AA)
1 194 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ct4tH12
[NCBI] 		2825031 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015534 [NCBI]
CDS location
range 1407 -> 2744
strand -
CDS
ATGCTTTTTTATCATTTTGATTGCTGCTTTACTCAATTTGTAGGAGTGCACAAAAGCAATATACGCAATATGTGTATTTTAACCAATCTCGAACAAAAAAGGAGTGTGTCAATTATGTCAACGTATCAATTTGACGACAAAACCCAACTGTCAGCACATTTTAACGTGCAAGAGTTTAAATGCCAGTGCGGTAAATCGCACGATATTTTAATAGACAGCGGTCTAATAGACAAGTTAGAGCGGCTTTACACCGCCCTAAATTGCAGTAAAATCATTGTGACAAGCGGTTATCGCTGCCCAGAGCATGACAAGGCTGTAGGCGGTACAAGCAGCGGTCAGCACACCAAGGGCACGGCTGCGGATGTTTGTTGCTACGGGCAGGACGGGCAGCCCATCAGCAGCAAGACGGTGTGTTGCAAGGCTCAGGATTTAGGCTTCGGCGGTATTGCCAACATCACAAGTAGTTATCAGTACACGCATTTGGACGTGCGGACAGGATACCGCTGGTTAGGCGACGAGGTCAAAGGCAATGGCACTGTTACAGAGGATTTTTACAAGTATTTTGGTATCAAAAAAGCCGCCGAAACAACAAGCGTTTTAAAAGGGATTGATGTGTCATACTGTCAAAACGAGGTTGACTGGGACGCTGCAAAGGCATCTGGACTGGTTGACTTTGCGATTTTACGGGCTGGATATGGTAGAGAGCCAAACCAAGTTGATACACAATTTAACCGTAACTATGCCGCTTGTAAGCGTCTGGGCATCCCCTGCGGTGCGTACTGGTTTAGTTATGCGATGTCGGCAGACGAGGCAAGACGTGAAGCACAGGTGTTTTTGCAGACCATTAAGGGCAAATCGTTTGAGTACCCGGTTTATATGGATTTGGAAAACGAAAAGCAATTTGCACTGGGAAAATCGGCTTGCTCTGCGATAGTAGACGCATTTTTAAGCGTGTTGGAGCAATCCGGATACTATGCCGGTCTATATTGCAGCACCTACTACTTAGATAATTACCTATCAGATAGCATCAAAAGCCGTTATACGGTCTGGTGTGCCCAGTATGCAAGTAAATGCACATATCAAAATCCATACGGTATCTGGCAGTATAATGTAGCTGGTAACGTTGAGTATGACATTATTGGGCAAAAAAGTATCCCTGGTATTGTTGGCGAGTGTGACATGGATTACTGTTACACCGATTACCCAGCAATCATAAAAGCTGCCGGATTGAACGGCTTCACGAAAACAACGCAGCCGACCGAGTCTGAACCAGACACTGAAGAATCTACGCTACAGCAGATTTTAAAGCATGTTGCATCATTGGATGCAAAATTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3k10b) rather than this protein.
PDB ID
3k10b
Method AlphaFoldv2
Resolution 83.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50