Protein

Protein accession
A0A8S5PIX6 [UniProt]
Representative
3WNFa
Source
UniProt (cluster: phalp2_34847)
Protein name
PlyB like endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 93% (predicted by ML model)
Protein sequence
MTKNEAIQKVLTIAENEVGYLEKKNGNNLDHKTTNAGSANYTKYGYEMHNLYPKVMDYPAAWCCAFVSWILYKAFGMDKAKQLMCGDIDDYTVAAAARYKNKKRYFKTPEIGDQIFFKNALRICHTGIVYKVDSTKVYTIEGNTSSGAAVIENGGGVFKKSYLLSNARIDGYGRPDWSCVSSEANTGNPSSASGSSMKVLETILDVSKYNTVDFAKAAGGYPGVMIRVGYRSYAKGELTLDPKFVDHAKNALAAGMKIGVYFYDQSLNESEAIQQADFVIGLIKALPISYPVFIDSEYSNANHNGRADSLSKDVRTKNIIAFCERIKSCGYQAGVYASDSWFKSMVDFGKLKEYEIWCARYSDSAPTIPKYDIWQCGSQIVPGSSSAVDINKVYKKYSDNTKTPSSPEDNSYCYCRVNVKTSLNVRNKPSLSGKVVGHLTGDLAINVTTLDNGWCKISSDEQWCSYKYIVPTKGTVVNCNLLNFRSESNTSSKILKTLKCGEKLNILSKTGNWYYAEKDGVAGYVSCSYITTT
Physico‐chemical
properties
protein length:533 AA
molecular weight:58992,2 Da
isoelectric point:8,78
hydropathy:-0,36
Representative Protein Details
Accession
3WNFa
Protein name
3WNFa
Sequence length
532 AA
Molecular weight
59359,52800 Da
Isoelectric point
8,03800
Sequence
MSKIGHSSIDERGKSSGGQAGDQNSREVCFSSWFDKKWGYVLRPKDKTIAEKMADACEKGCTNNMIGYDQKQRNSLKTQAVAHGMDLSKIKTPCECDCSSFMTVCAECAGIKIPYNGANAPTTSTMQKAFMSTGAFDLLTDSKYLTSDKYLKRGDVIVKPGSHTIMCLEDGSKANETNTTILRAIDISKYNTITNYTNMIKEVPNVFIRVGYRSYEKGILTEDPLFKKHMDNCVANGATIGIYYYDQSLNEAEAEEQSVWVANKLQGYKIDLPVFIDSEYSNSDHNGRADNISKEQRTRNIIAFCEKIKSAGFTPGVYASDSWFQSMVEFDKLKNYIIWCARYSTNKPTISKYDIWQYGSENYSWATGAIDTNIIYSDLKCTQTGVKPAVIPTSNTQTGITPEKTILLMGQVNIKEGTLNVRKAPSTNSQIVLQLQKGAYVQLRGDLGDWYRMDIGYVSKEYIKEVHGIVTGDNLRVRSTPDTSLQTNIITTLPVNTEVIICTAGNGWYYVLLNDGRTGWVSGQYIKLKGES
Other Proteins in cluster: phalp2_34847
Total (incl. this protein): 8 Avg length: 517,8 Avg pI: 8,57
Protein ID Length (AA) pI
3WNFa 532 8,03800
1gyLO 530 8,47329
21qos 458 9,10727
4kos3 528 8,49469
7DEcX 527 8,68455
7DEd4 527 8,61028
7NOcN 507 8,36634
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33970
406sB
 17 28,7% 400 1.096E-63
2 phalp2_38322
omZS
 1 32,8% 347 5.047E-56
3 phalp2_37241
3vd83
 5 23,9% 501 2.004E-48
4 phalp2_35723
3WLH4
 2 27,8% 391 4.351E-38
5 phalp2_12878
2omQf
 1 26,5% 565 6.691E-35
6 phalp2_10422
21gLF
 1 26,2% 374 9.892E-31
7 phalp2_24673
5KMWz
 154 26,1% 383 5.607E-30
8 phalp2_10110
c1k0
 16 22,9% 336 1.001E-27
9 phalp2_11344
7rGpn
 1 23,5% 339 1.276E-24

Domains

Domains [InterPro]
Unannotated
GH25
SH3_3
Representative sequence (used for alignment): 3WNFa (532 AA)
Member sequence: A0A8S5PIX6 (533 AA)
1 532 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctL0q1
[NCBI] 		2825449 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015443 [NCBI]
CDS location
range 1607 -> 3208
strand -
CDS
ATGACTAAAAATGAAGCAATCCAAAAGGTTTTGACCATTGCAGAAAATGAGGTCGGATACCTCGAAAAGAAAAACGGAAACAATTTAGATCACAAGACTACAAATGCCGGATCTGCGAATTACACAAAATACGGATATGAGATGCATAATCTTTATCCGAAAGTGATGGATTATCCGGCTGCGTGGTGCTGTGCTTTCGTTTCGTGGATTTTGTACAAGGCGTTCGGAATGGACAAGGCGAAACAGCTCATGTGTGGCGACATCGACGACTACACCGTTGCTGCCGCTGCCAGATACAAAAACAAGAAGCGTTATTTCAAAACGCCTGAAATTGGCGATCAAATTTTCTTCAAAAATGCTCTTCGAATTTGTCACACGGGTATTGTTTATAAAGTCGATTCCACAAAAGTGTATACTATTGAGGGGAATACGAGTTCCGGCGCTGCCGTTATTGAGAATGGCGGAGGTGTATTCAAAAAGAGTTATCTTCTCTCCAACGCTAGAATTGATGGGTATGGACGTCCCGATTGGAGCTGTGTCTCATCGGAAGCGAATACTGGGAATCCTTCGTCTGCATCCGGATCTTCCATGAAGGTTCTTGAAACTATTTTAGATGTTTCTAAATACAATACGGTTGATTTCGCAAAGGCTGCCGGAGGTTATCCCGGCGTGATGATTAGAGTTGGATATCGTTCTTATGCAAAGGGCGAATTGACACTTGATCCGAAATTTGTAGATCATGCGAAAAATGCGCTTGCTGCCGGAATGAAAATCGGAGTCTATTTTTACGATCAATCGCTAAACGAATCTGAAGCTATTCAGCAGGCCGACTTCGTTATTGGTTTAATCAAGGCGTTGCCGATCTCCTATCCGGTTTTTATCGATTCGGAATACTCCAATGCGAATCATAATGGACGCGCAGATAGTCTATCGAAAGATGTTCGCACGAAGAATATAATCGCTTTTTGCGAGCGTATTAAGTCTTGCGGTTATCAGGCAGGAGTTTACGCTTCGGACAGTTGGTTTAAATCTATGGTGGATTTTGGCAAATTAAAGGAGTATGAGATTTGGTGCGCAAGATACAGTGATTCTGCACCGACGATTCCCAAATACGACATTTGGCAATGTGGTTCACAAATTGTTCCTGGTTCATCTTCTGCCGTGGATATAAATAAGGTTTATAAGAAATATTCTGATAACACAAAAACACCATCGTCACCCGAAGACAATTCTTATTGTTATTGCCGCGTCAATGTAAAAACGAGTTTAAATGTCAGGAATAAACCCTCGCTGAGCGGAAAAGTCGTTGGACACTTAACCGGTGATCTCGCGATTAACGTCACAACACTTGATAATGGATGGTGTAAAATTTCTTCGGATGAGCAATGGTGCTCTTATAAATACATTGTACCAACAAAGGGGACAGTTGTAAACTGTAATTTGTTAAATTTTAGATCGGAATCCAATACATCTTCTAAAATTTTAAAGACGCTGAAATGCGGTGAAAAACTGAATATTCTTTCTAAAACGGGAAACTGGTATTACGCGGAAAAAGATGGTGTCGCAGGGTACGTTTCTTGTTCTTATATTACTACAACGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3WNFa) rather than this protein.
PDB ID
3WNFa
Method AlphaFoldv2
Resolution 90.07
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50