Protein

Protein accession
A0A8S5PIT0 [UniProt]
Representative
8ond8
Source
UniProt (cluster: phalp2_22772)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MFNGIDVSRHQGDIDWDSVNPHIDFSMIRAGFGKNNIDAKARRNVSECERLGIPYGLYWFSYALHPEMAKKEAEYLIEFIGEHKPEYPIVYDFEYDTVTHATKNGVSINRQFVLDSTEEFCRTLEEHGFYAMFYTNRDYYQRYYQASKVAEKYDMWYARYSQSAGRKVTLWQYSDKGKLPGISGYVDLDRTERDYPLIIKKNNLNNWR
Physico‐chemical
properties
protein length:208 AA
molecular weight:24695,3 Da
isoelectric point:6,09
hydropathy:-0,75
Representative Protein Details
Accession
8ond8
Protein name
8ond8
Sequence length
374 AA
Molecular weight
41527,14370 Da
Isoelectric point
9,22170
Sequence
MLKGIDVSDHQERINWDKVKPNIDFAIVRAGWGNHTIDSQAHRNVSECNRLSIPVGLYWFSYAYNVDMAIHEARLCLEFAKKYRIDYPIVYDLEVASLNWAKRVGHPISKRTATDMAKAFMREVEKAGYYAMLYANPNLFDVAYYRDELCPRFALWLAWYKVSVDTAKRYNPKIFQYSESGSMSGIGTNSVDLDYGFEDMAVTIRKKGLNHLDGSKPYKPSSNSSSSSSSSSSSSSSGKWGECTGNGVRVRKGASTSSEIIGQLNKGDKVQLDNKVGNWWSTFYGAHGGFVSADYIKVLDGSSSSSSSSSSSGKWGVVTGNGVRVRSGCSLSSKIIGQVNKGFKVKLENRVGDWWSTDYGAHGGFIHKDYIRVL
Other Proteins in cluster: phalp2_22772
Total (incl. this protein): 4 Avg length: 313,0 Avg pI: 7,78
Protein ID Length (AA) pI
8ond8 374 9,22170
78kB4 304 6,83446
7xQIa 366 8,98826
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26548
858CP
 728 38,9% 244 4.178E-57
2 phalp2_10747
3nEcV
 19 33,3% 282 1.443E-56
3 phalp2_9816
8nOwP
 1 32,8% 250 2.565E-49
4 phalp2_15044
7hFHn
 33 31,9% 247 1.216E-46
5 phalp2_529
o3Q8
 73 30,7% 247 9.604E-36
6 phalp2_31512
3WNwM
 280 31,3% 249 7.583E-33
7 phalp2_9283
7cTgF
 101 33,6% 247 5.201E-31
8 phalp2_37241
3vd83
 5 24,6% 389 1.132E-25
9 phalp2_18637
9X15
 5 26,2% 255 1.524E-25
10 phalp2_11344
7rGpn
 1 24,5% 366 9.082E-25

Domains

Domains [InterPro]
GH25
SH3_3
SH3_3
Representative sequence (used for alignment): 8ond8 (374 AA)
Member sequence: A0A8S5PIT0 (208 AA)
1 374 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ctHkH8
[NCBI] 		2825236 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015426 [NCBI]
CDS location
range 8181 -> 8807
strand -
CDS
ATGTTTAATGGAATTGATGTATCCAGGCACCAAGGAGACATTGACTGGGATAGCGTTAATCCTCATATCGACTTTTCCATGATACGTGCTGGTTTTGGAAAGAACAACATTGATGCTAAAGCCAGAAGAAACGTATCAGAATGTGAAAGATTAGGAATCCCATACGGCCTTTACTGGTTCAGCTACGCGCTACACCCGGAAATGGCTAAAAAGGAAGCCGAATACTTAATTGAGTTTATCGGAGAACATAAGCCGGAATATCCAATTGTGTACGACTTTGAGTATGATACGGTAACACATGCCACGAAAAACGGTGTAAGCATTAACAGACAGTTTGTGCTAGACAGCACAGAAGAATTTTGCCGCACCCTGGAAGAACACGGATTTTACGCTATGTTCTACACGAACCGGGATTACTACCAGCGTTACTATCAGGCAAGCAAAGTGGCTGAAAAGTATGACATGTGGTACGCAAGGTACTCACAGTCAGCAGGTAGAAAGGTAACACTGTGGCAGTATTCCGACAAAGGTAAACTGCCTGGTATTTCAGGTTATGTCGATTTAGACAGAACCGAACGTGATTACCCTTTAATCATTAAGAAGAACAACCTTAACAACTGGAGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8ond8) rather than this protein.
PDB ID
8ond8
Method AlphaFoldv2
Resolution 83.56
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50