Protein

Protein accession
A0A8S5PGK5 [UniProt]
Representative
3nxgr
Source
UniProt (cluster: phalp2_24298)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRLKNEEALLHWPLAQHIITAGWLYNDGSLHRALDFRAAVGTPVYAAEGGTVAIAYHWNGKRTQGDTNSYGNMIKLRHADYRGGRLETLYAHLSKLCVAQGETVYEGQLIGYSGDTGNCYGAHPHFEVRWKGQRTNPLNWLDADFSTASSAVKLGSYSSVAHNMKEVEYMNYAIDVSKHQGKFNWQAAYDKGIRHAMLRAGYGRYSSQKDPQFERNSVECTRLGIQYGVYWYSYATTPEEARQEARCCLAAIKDKHLCLPVAYDIEYEPCILRLTNAQRTALVQAFLSEIEAAGYYGILYASRDFIRNRLDYKVLSKYDIWVAQYSSTCTCPLPYGIWQYSSRNALGIPGYGTSLDCNRVYKDYEQLMIQAGLQGHTAPTPEDTTPNKLDKQQITIGRISSGDRSTIRALCEGLGLIAAGLYRETCADGNQWMLDIGPVSSGDAWYIMRKCAELQLIDAGLYKAEYVEE
Physico‐chemical
properties
protein length:469 AA
molecular weight:52752,9 Da
isoelectric point:6,67
hydropathy:-0,40
Representative Protein Details
Accession
3nxgr
Protein name
3nxgr
Sequence length
336 AA
Molecular weight
37894,27850 Da
Isoelectric point
8,22019
Sequence
MRLKNEEALLHWPLAQHIITAGWLYNDGSLHRALDFRAAVGTPVYAAEGGTVETAYRWNGKRTQGDINSYGNMVKLRHTTYKYGTLETLYAHLSKLCVTQGQQVQEGQLIGYSGDTGNCYGAHLHFEVRWRGNRTNPLNWLDNDFSTASGAVKLGSYSSVAHNMKEVEYMNYAIDVSKHQGKFDWQAAYDKGIRHAMLRAGYGRYSSQKDPQFERNAAECTRLGIQYGAYWYSYATTPAEARQEARCCLAAIKGKHLCLPVAYDIEYEPCILRLTNAQRTALVEAFLGEVEAAGYYGILYASCDFIRHRLDYKALSKYDIWVAQYGSACTCPLPYG
Other Proteins in cluster: phalp2_24298
Total (incl. this protein): 64 Avg length: 267,6 Avg pI: 7,23
Protein ID Length (AA) pI
3nxgr 336 8,22019
1nfK0 211 6,74550
1nlEf 211 6,78683
2lS7R 212 6,36679
2lTiq 211 6,74533
2lZ8s 211 6,74459
2mbw8 211 6,74550
2mcVz 211 6,69765
3KEoQ 335 8,25300
3l69u 361 8,50501
3lRrp 211 7,72814
3lV6C 211 7,78238
3m4rL 211 7,78238
3mxsh 211 6,74459
3pYKm 211 6,53702
3qJMg 211 8,40992
3qJZB 211 6,53781
3r3GC 211 7,12183
3rUzo 211 7,77768
3rgia 211 8,39928
3sDTb 211 6,74533
3sako 211 6,74533
3skJB 211 6,53696
3su3y 211 7,78270
3susH 211 6,74533
3tVHd 211 7,12149
3tamk 211 6,28431
3tkcy 276 8,57811
3u703 211 6,48910
3ubr9 211 7,12149
3vy6R 211 7,12087
3w8to 211 7,78264
3wkDz 211 6,70032
3wn3Y 211 6,53702
3xqMC 211 6,74459
3yCpH 211 6,74459
3yDa7 211 6,53702
3yQim 212 7,73672
3ygAH 468 7,17890
4VLnC 344 8,84643
4z3ri 211 6,74459
4z7L7 211 6,78643
5LaVK 354 8,56973
5Nbmp 285 5,75270
5RMIl 217 9,19282
5XT42 211 6,34729
66WMV 469 8,25558
6YOgy 211 6,53810
6atnP 212 7,74235
6pNEt 481 6,67724
6qycz 481 7,13116
6s1j5 226 8,69351
85iDy 211 6,69765
8eoNT 211 6,53810
8ffaq 469 7,49635
8mPvJ 212 8,37601
EFe9 211 6,78603
EI47 481 6,93296
IFCX 481 6,67508
KIMi 346 8,72936
NuE2 481 6,70185
O7VK 481 7,49379
p0Qf 211 6,74459
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8516
1nmLt
 187 85,1% 336 2.891E-196

Domains

Domains [InterPro]
PET_M23
GH25
Representative sequence (used for alignment): 3nxgr (336 AA)
Member sequence: A0A8S5PGK5 (469 AA)
1 336 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctXQ92
[NCBI] 		2825543 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015427 [NCBI]
CDS location
range 4356 -> 5765
strand +
CDS
ATGCGGCTGAAGAATGAAGAAGCCCTGCTGCATTGGCCCCTGGCCCAGCACATTATCACCGCAGGCTGGCTCTACAATGACGGCAGCCTGCACCGGGCGCTGGATTTCCGCGCAGCCGTTGGCACCCCCGTGTACGCCGCAGAGGGTGGCACGGTTGCAATCGCGTACCACTGGAACGGCAAGCGCACCCAGGGAGATACCAACAGTTACGGCAACATGATCAAGCTGCGCCATGCGGATTACCGCGGCGGCCGGCTGGAGACGCTGTACGCCCATTTGAGCAAACTCTGCGTGGCCCAGGGGGAGACGGTATACGAGGGCCAGCTAATCGGCTACAGCGGCGATACTGGCAACTGCTATGGAGCACACCCGCATTTTGAAGTGCGCTGGAAAGGCCAGCGCACCAACCCGCTGAACTGGCTGGATGCTGATTTCAGCACGGCCAGCAGCGCGGTAAAATTGGGCAGCTACAGCAGCGTAGCGCACAATATGAAGGAAGTGGAATACATGAATTATGCAATCGACGTGTCAAAACATCAGGGCAAATTCAACTGGCAGGCGGCGTATGACAAGGGCATCCGCCATGCCATGCTGCGCGCCGGGTATGGCCGCTACAGCAGCCAGAAAGACCCCCAGTTTGAGCGCAACTCCGTGGAGTGCACCCGGTTGGGTATCCAGTACGGCGTGTACTGGTACAGCTACGCCACCACGCCGGAGGAAGCACGGCAGGAAGCCCGCTGCTGCCTGGCAGCGATTAAGGACAAGCACCTGTGCCTGCCGGTGGCCTATGACATTGAGTACGAGCCGTGCATTTTGCGTCTGACCAACGCGCAGCGCACGGCACTTGTACAGGCCTTTTTGTCGGAGATTGAGGCCGCAGGGTATTACGGCATCTTGTATGCCAGCCGCGATTTTATTCGCAACCGCTTGGACTATAAGGTTTTGTCAAAATATGATATCTGGGTAGCCCAGTACAGCAGCACATGCACCTGCCCCCTGCCGTATGGCATCTGGCAGTATTCCAGCCGCAACGCCCTGGGCATCCCCGGCTACGGCACCAGCCTGGACTGCAACCGGGTCTACAAGGACTATGAACAGCTGATGATCCAGGCGGGCCTGCAGGGCCACACCGCGCCCACCCCGGAGGATACCACCCCCAACAAGCTGGACAAGCAGCAAATCACCATTGGCCGTATCTCCAGCGGCGACCGCAGCACCATCCGCGCCCTGTGCGAGGGGCTGGGGCTGATCGCGGCGGGCCTGTACCGCGAAACCTGTGCGGATGGCAACCAGTGGATGCTGGACATCGGCCCGGTATCCAGCGGCGACGCCTGGTACATTATGCGCAAGTGTGCAGAGCTGCAACTGATTGATGCAGGGCTGTACAAGGCCGAATATGTGGAGGAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3nxgr) rather than this protein.
PDB ID
3nxgr
Method AlphaFoldv2
Resolution 92.20
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50