Protein

Protein accession
A0A8S5P543 [UniProt]
Representative
1HHLO
Source
UniProt (cluster: phalp2_29475)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRIYNVPDVSEHQQNFDFTPYAGKYAILRAGVAGREDYSFRRHVSECQRLGITIGVYFYSYALNTAQAIEEAQRFLSIIDGVDIGLGAWLDMEDADHYKVNNGVYITHDNIAPMSRAFCDVIAAAGYYTGIYTSLSWLGYLAPECDPYDKWVAAWGNNDGSHTVDTSAYGTIQQYTSNYGTLDENVIFVDPSIYRTGATADRPVEYVQTPTQLPVATSENVYVAQYGDTLSGIAAKFGTTYQHLAEINGISDPNVIYAGQEIVISGEPVANTSDEVYYTIQDGDTLSGIAERYGTSYQYLAYLNGISNPNVIYAGTTIRIR
Physico‐chemical
properties
protein length:321 AA
molecular weight:35487,7 Da
isoelectric point:4,43
hydropathy:-0,21
Representative Protein Details
Accession
1HHLO
Protein name
1HHLO
Sequence length
99 AA
Molecular weight
10766,77680 Da
Isoelectric point
4,10556
Sequence
VVQYGDTLSGIAAKFGTTYQYLAEINGIADPNVIYVGQEIVINGEPVANTSDEVYYTIQDGDTLSGIAERYGTSYQYLAYLNGISNPNVIYAGTTIRIR
Other Proteins in cluster: phalp2_29475
Total (incl. this protein): 21 Avg length: 173,8 Avg pI: 5,32
Protein ID Length (AA) pI
1HHLO 99 4,10556
2m11P 74 4,23305
3wFc5 179 4,77757
4XSyH 92 4,43824
5UhoG 136 4,68890
61Bg8 134 9,52193
63ze2 141 6,93927
65YsI 224 4,22901
6jNmF 84 5,79317
755L4 164 5,73707
790E6 120 4,54794
7BXjl 133 4,83583
7DWrb 165 4,80957
7QBfT 166 5,28253
8HFDA 158 4,96502
8HFDz 166 5,28253
EXX4 131 9,69806
A0A8S5MNR8 321 4,43477
A0A8S5PP14 321 4,50014
A0A8S5QIU8 321 4,38924
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28052
75Rgb
 8 55,5% 99 3.725E-35
2 phalp2_11520
Nmla
 4 48,4% 95 8.311E-26
3 phalp2_4894
5TthI
 1 37,7% 98 8.590E-19
4 phalp2_16418
6hjNP
 6 36,0% 97 4.185E-18
5 phalp2_23980
3uGTe
 3 35,0% 97 3.843E-17

Domains

Domains [InterPro]
LysM
LysM
Representative sequence (used for alignment): 1HHLO (99 AA)
Member sequence: A0A8S5P543 (321 AA)
1 99 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctLRE27
[NCBI] 		2825083 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015330 [NCBI]
CDS location
range 12564 -> 13529
strand +
CDS
ATGAGAATTTACAATGTACCTGATGTTTCCGAACATCAACAAAATTTTGACTTCACACCTTACGCAGGAAAGTATGCTATCTTACGTGCTGGTGTTGCAGGGCGTGAAGACTATTCATTCAGACGACATGTTTCAGAGTGCCAACGTTTAGGCATTACAATCGGTGTTTACTTCTATTCCTATGCGCTAAACACAGCACAGGCAATCGAAGAAGCACAGCGCTTCTTATCCATCATTGATGGCGTGGATATTGGGCTTGGTGCATGGCTTGATATGGAAGATGCCGACCATTACAAAGTTAATAACGGCGTATATATTACACACGATAACATCGCGCCTATGTCACGTGCATTCTGTGATGTGATTGCGGCAGCTGGATATTACACAGGCATTTACACGTCGCTATCATGGCTTGGCTACCTTGCGCCTGAATGTGATCCATACGATAAGTGGGTAGCGGCTTGGGGAAACAATGACGGAAGCCATACGGTTGATACATCTGCATACGGAACAATCCAACAGTACACTTCTAACTATGGAACATTAGACGAAAATGTAATCTTTGTTGACCCATCAATCTATCGCACTGGTGCAACAGCAGATAGACCGGTTGAATATGTTCAAACGCCTACACAGTTACCAGTTGCAACAAGCGAAAACGTTTATGTCGCTCAATATGGAGATACACTGTCAGGAATTGCGGCTAAGTTTGGAACGACTTATCAACACTTAGCAGAAATCAACGGCATCTCAGACCCTAATGTTATCTATGCTGGACAAGAAATTGTCATCAGCGGCGAACCAGTTGCTAACACAAGCGATGAGGTTTATTACACAATCCAAGACGGCGATACATTGAGCGGTATTGCGGAAAGATACGGCACATCTTATCAGTATCTTGCATATCTGAACGGTATTTCAAATCCCAACGTTATTTATGCTGGAACTACAATCAGAATTAGATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1HHLO) rather than this protein.
PDB ID
1HHLO
Method AlphaFoldv2
Resolution 84.78
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50