Protein

Protein accession
A0A8S5P2Z8 [UniProt]
Representative
1KOZ4
Source
UniProt (cluster: phalp2_29484)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MIEKGKPFTQWGSDSLELAKQLIADFEGFRSKAYKCQAGVLTIGYGHTKGVKEGMTISEDEAEKLLWGDLVRLKHDVAPLINVGVTEGQFIALLSFAYNVGVGNLKKSTLLRLLNSGSYSHASEEFAKWIYVKGQPSKGLMNRRKKEREYFDTEEG
Physico‐chemical
properties
protein length:156 AA
molecular weight:17436,7 Da
isoelectric point:8,56
hydropathy:-0,39
Representative Protein Details
Accession
1KOZ4
Protein name
1KOZ4
Sequence length
197 AA
Molecular weight
21780,03530 Da
Isoelectric point
9,18360
Sequence
MRYPNAVGAINIINVSLLIALGIAVTAPTVQPDQFVTYAPPPALEVVWPTRELIVYPEVATVSGVDLIKRFEGLRLKAYKCTAKRWTIGYGRAYGVKSGQVITQAEADRMLSVDYAKTKSAVLSAVKADISDQQIEVLVSFAYNVGITRFKESTMLKMINAGDMRGARDQFRFWIHVDGQPIDGLINRRAEEAALFI
Other Proteins in cluster: phalp2_29484
Total (incl. this protein): 4 Avg length: 175,0 Avg pI: 9,19
Protein ID Length (AA) pI
1KOZ4 197 9,18360
1KwAg 197 9,32266
A0A2D2W2U6 150 9,67646
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28113
7zmZV
 50 50,0% 140 1.115E-47
2 phalp2_2632
6RhYr
 14867 48,8% 135 1.126E-44
3 phalp2_6830
8n5Jv
 121 46,8% 143 2.904E-41
4 phalp2_4451
31DIk
 4919 47,5% 141 2.617E-40
5 phalp2_33221
5jbqV
 447 45,9% 137 3.227E-39
6 phalp2_126
5jCCA
 637 47,3% 133 1.550E-38
7 phalp2_26378
1q5mp
 207 43,3% 143 3.576E-37
8 phalp2_14481
4Lj5N
 23 44,0% 134 6.697E-37
9 phalp2_4532
3QBcV
 9 43,0% 144 1.127E-35
10 phalp2_15045
7iQxx
 18 42,7% 138 1.542E-35

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 1KOZ4 (197 AA)
Member sequence: A0A8S5P2Z8 (156 AA)
1 197 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctakU3
[NCBI] 		2825135 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015306 [NCBI]
CDS location
range 5005 -> 5475
strand -
CDS
GTGATCGAAAAAGGCAAACCATTTACGCAATGGGGTAGTGATTCGTTGGAGCTAGCCAAGCAGTTAATCGCTGACTTCGAGGGCTTTAGATCTAAGGCTTATAAATGTCAAGCAGGTGTTCTAACGATAGGCTACGGACACACAAAAGGCGTTAAAGAAGGCATGACGATCAGCGAGGACGAAGCCGAGAAGCTTCTATGGGGCGACCTAGTCCGCTTAAAGCACGATGTTGCGCCACTTATTAATGTGGGTGTTACCGAAGGGCAGTTTATCGCGCTTTTGTCTTTTGCTTATAACGTGGGGGTTGGTAACCTCAAGAAATCAACCCTATTACGTCTACTCAATAGCGGAAGTTATTCACACGCTAGCGAAGAGTTCGCCAAGTGGATTTACGTTAAAGGGCAACCGTCTAAGGGGCTGATGAACCGTAGGAAAAAAGAGAGGGAATATTTCGATACCGAAGAAGGCTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1KOZ4) rather than this protein.
PDB ID
1KOZ4
Method AlphaFoldv2
Resolution 79.69
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50