Protein

Protein accession
A0A8S5NR41 [UniProt]
Representative
2m4j4
Source
UniProt (cluster: phalp2_39103)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MDISYWQGNVDFARVAADGIKFAILREGYAQTVDAKFRQYVEGCRKNGIEIKGVYHFSYAINAEQAAQEAAFCIKQMEQAGLGKDVIVFYDFEYDTVKKAKAKGVTLGKNECIAFTKAFCEYVESHGYKAGVYSNIDYHRNMYSDEVLSKYVYWLADYTGSPDYDCAFHQYTSSGTVSGIDGKVDMDYYYGEEIKENQGEKKSVTEVAKEVLAGDWGNGDDRKNRLAAAGYDYATVQAEVNRLAGATSAPKKSVAEIAKEVIAGQWGNGDDRKNRIKAAGYDYDTVQKEVNAQLGVKSQKSVTEVAKEVIAGKWGNGETRKQKLKAAGYDYAAVQKKVNELL
Physico‐chemical
properties
protein length:342 AA
molecular weight:37976,0 Da
isoelectric point:5,96
hydropathy:-0,55
Representative Protein Details
Accession
2m4j4
Protein name
2m4j4
Sequence length
297 AA
Molecular weight
33687,80990 Da
Isoelectric point
5,30810
Sequence
MKKGIDISYWQGNIDFSKVAKNVDFVILREGYRKTVDPKFMEYVNGCKKNGIPIKGVYHFCYATSAAGAREEAAVCMENIKKAGLGKDVIVFFDFEYDTVEKAAAQGVKLGKSECILFTKEFCTYVESQGYTPGIYSNLDYYRNMYEPDLIKKYVFWLADYSGEADVPCAYHQYTNKGKVPGINGDIDMDYFYDTENKEDGNMGRTAQDYLNVWRSWLGFSEANGKFKQIIDLYNSHKPLARGYAVQYRDEWCDTIVSAAAIAAGMVDLIGTECGCEEHVKIFKAKGIWIEDGERSC
Other Proteins in cluster: phalp2_39103
Total (incl. this protein): 107 Avg length: 335,2 Avg pI: 6,28
Protein ID Length (AA) pI
2m4j4 297 5,30810
13BoK 347 6,48439
1FXEf 373 5,42314
1mdTV 347 6,90846
1nfaC 347 6,18899
1o36A 245 5,22000
24qGb 270 5,01277
2aUyF 291 8,96209
2lPxJ 347 6,18587
3VDnm 275 9,47455
3axfv 292 5,14952
3k5zR 532 8,26286
3k9wS 347 6,18621
3kt8o 346 6,18894
3m5tj 347 6,18621
3mxKJ 398 9,07942
3p86I 347 6,48450
3qLBg 347 5,95590
3r2G1 347 6,90738
3sJBe 347 6,18894
3sekp 347 6,48251
3tVr9 291 5,43616
3tYAh 323 8,93069
3tjiS 347 6,18894
3vsSW 347 6,18894
3yCrc 347 6,27658
4VKJk 347 6,39123
4VXUC 270 6,32370
5LpDt 347 6,18894
5MmsQ 347 6,18621
5MtRC 347 6,18621
5NSV9 347 6,48365
5OWpJ 347 8,01427
5Oh41 347 6,18621
5ROKb 347 6,18894
5T4TQ 347 6,18621
5TATL 347 6,48439
5TUut 297 5,93214
5Tsmu 381 9,14150
5UtMN 347 5,96192
5VPYx 347 6,18621
5VnEp 347 6,18894
5WTsp 347 5,96192
5X9xI 347 6,18621
5XUu2 347 5,96556
5XX21 347 6,18706
5XXfX 347 6,18621
5ZTyc 347 6,48251
63xTy 347 6,48251
64UKV 347 6,90926
65DG9 407 5,67807
66IwO 294 5,15850
66UAT 347 6,18621
66VCx 347 7,52244
66YE3 347 6,18894
67RlY 347 6,18621
68GdY 347 6,18621
6YcdR 347 6,18894
6YjwN 246 4,97588
6ac2C 395 5,81118
6as6o 347 6,90846
6cK67 347 7,52425
6eV7t 347 6,18621
6eZC9 347 6,48251
6fO8M 299 6,16217
6gjWK 347 6,48251
6h8eY 347 6,90778
6hmJ1 203 8,39038
6hxSm 347 6,18894
6iS19 347 5,95556
6ijqy 347 6,18894
6irIJ 347 6,48251
6jtAN 347 6,18894
6k2VU 347 6,18621
6lO7O 348 6,90875
6ltQD 347 6,48439
6m57M 244 5,06159
6mLbo 347 6,27653
6pAIa 347 6,18621
6pH0R 347 5,95573
6pM8o 347 6,90738
6posx 347 5,95823
6px6Y 347 6,48240
6qWSV 347 6,18621
6qvbF 347 6,18621
6sj4z 347 6,18621
6ssKh 347 6,18621
6tObk 347 6,27653
6uF2W 347 5,96556
6vgzO 347 6,18894
7GfVV 288 5,03471
7MeR6 246 4,97588
7OJaU 217 5,28815
7VRRq 294 5,15850
7VrwA 347 5,95323
7X9qM 330 5,46356
8fPYY 347 6,18621
8ghPK 347 6,18894
8mFcf 217 4,89613
8t8sX 347 6,18621
KNBQ 341 4,61643
MPkE 288 5,03857
MSJ1 347 6,18894
pTgU 311 5,41240
rjnt 347 6,48058
A0A8S5NT81 342 5,77151
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4916
6k3vw
 208 43,2% 319 5.620E-90
2 phalp2_23963
24Ldx
 5 30,8% 408 1.056E-80
3 phalp2_33310
6kV0o
 68 41,3% 215 4.803E-65
4 phalp2_38736
13rhz
 58 31,3% 341 7.837E-61
5 phalp2_10789
3TIsE
 2 40,7% 211 1.787E-59
6 phalp2_24035
8aWkT
 56 40,5% 222 4.564E-59
7 phalp2_35163
5M5qW
 20 39,5% 200 2.555E-54
8 phalp2_35683
3zpKE
 30 38,9% 195 6.664E-49
9 phalp2_26548
858CP
 728 41,5% 200 5.205E-47
10 phalp2_3425
3TK4D
 923 37,4% 219 6.269E-46

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 2m4j4 (297 AA)
Member sequence: A0A8S5NR41 (342 AA)
1 297 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudovirales sp. ct0YK8
[NCBI] 		2826764 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015222 [NCBI]
CDS location
range 45673 -> 46701
strand +
CDS
ATGGACATTTCATATTGGCAGGGCAATGTAGACTTTGCCAGAGTAGCAGCAGACGGCATCAAGTTCGCAATCCTTCGTGAAGGATACGCACAGACGGTAGACGCAAAGTTCCGCCAGTATGTGGAAGGCTGCAGAAAGAACGGCATCGAAATCAAGGGAGTATATCATTTCAGTTATGCGATCAACGCAGAGCAGGCAGCGCAGGAGGCGGCATTCTGCATCAAGCAGATGGAGCAGGCAGGTCTCGGAAAAGATGTGATTGTATTCTACGATTTTGAGTACGACACTGTAAAGAAAGCCAAGGCAAAGGGAGTAACCCTCGGAAAGAATGAGTGCATCGCATTTACAAAGGCATTCTGCGAGTATGTGGAAAGCCATGGATACAAGGCAGGTGTTTATTCCAACATCGACTACCACAGAAATATGTATTCGGACGAAGTGCTCTCCAAGTATGTGTACTGGCTCGCAGATTACACAGGATCTCCGGACTATGACTGCGCATTCCACCAGTACACCAGTTCCGGAACAGTAAGCGGCATCGATGGCAAGGTAGATATGGATTACTACTACGGAGAGGAAATCAAAGAGAACCAGGGCGAGAAGAAATCCGTCACTGAGGTGGCAAAGGAAGTGCTCGCAGGAGACTGGGGAAACGGAGATGACCGCAAGAATAGACTGGCTGCTGCCGGATATGACTACGCAACGGTGCAGGCAGAAGTGAACCGCCTTGCAGGAGCAACCTCCGCACCGAAAAAGAGCGTGGCAGAAATCGCCAAGGAAGTCATTGCAGGACAGTGGGGAAATGGCGATGACAGAAAGAACCGCATCAAGGCAGCAGGATATGACTACGATACAGTCCAGAAAGAGGTCAATGCACAGCTTGGAGTAAAATCGCAGAAAAGCGTTACTGAGGTAGCCAAGGAAGTGATCGCAGGTAAGTGGGGCAACGGCGAAACCAGAAAGCAGAAGCTGAAGGCAGCCGGATACGACTACGCAGCCGTGCAGAAGAAGGTCAATGAACTTCTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2m4j4) rather than this protein.
PDB ID
2m4j4
Method AlphaFoldv2
Resolution 93.04
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50