Protein

Protein accession
A0A8S5NP18 [UniProt]
Representative
5XE7n
Source
UniProt (cluster: phalp2_27614)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKVIDISDWNDHINWSHMFDKGVEGVIVKISEGRTLSELHGKHISAAAARGLPWGVYCYTHAQTTERAEEEAAVVIEALEALGYGAPPLGIWFDVEAPETIGQDRDDVTAICSAFISTCNATGYAAGIYASLSTLTDCMNLDDLADYVPTWCAQYNDECSFHDYFPGRILQGWQFTDAFEIDGRNYDMSEWY
Physico‐chemical
properties
protein length:192 AA
molecular weight:21411,5 Da
isoelectric point:4,26
hydropathy:-0,18
Representative Protein Details
Accession
5XE7n
Protein name
5XE7n
Sequence length
308 AA
Molecular weight
34507,72140 Da
Isoelectric point
4,33599
Sequence
MTSKVIDVSYYQKDIDYDAVEAAGVQGVIVKISEGCTEEDTWIRHVEECKTRGIPWGVYCFSHAQTPERAKEEAQTVLELLGADVPPMGIWYDCEADECFAEGVDTTDICSAFIVACNEAGHRAGIYTSTLKCTDSMTNSIRPNLLADYVPYWIADYRGYNGFSQDYPDKHVAGWQWSEHEYIGDTEVDMNEWYEELKMDEDNNNKKYTAKVVLVSFIIGVLLCLFGCVCFYSTRTESTESRNVNRTIQQLTTDGDRATEAVNGAETGLSESQDTADRISERADESASVLDRLQAELDRIAEANGLTE
Other Proteins in cluster: phalp2_27614
Total (incl. this protein): 3 Avg length: 232,3 Avg pI: 4,32
Protein ID Length (AA) pI
5XE7n 308 4,33599
A0A8S5R8I3 197 4,36833
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_5939
6bh0H
 94 56,5% 198 1.295E-72
2 phalp2_22740
8dpUt
 356 32,4% 231 1.981E-29
3 phalp2_12020
7Olig
 697 35,0% 211 1.047E-27
4 phalp2_13529
7Jyqc
 660 35,6% 205 6.512E-27
5 phalp2_3425
3TK4D
 923 32,3% 201 1.306E-20
6 phalp2_23950
235xP
 13 30,8% 201 1.934E-19
7 phalp2_8080
69Y9D
 21 29,2% 202 6.390E-19
8 phalp2_35163
5M5qW
 20 29,7% 202 1.564E-18
9 phalp2_27173
3dR30
 17 31,1% 228 2.838E-18
10 phalp2_14685
6l3sC
 9 34,6% 199 2.838E-18

Domains

Domains [InterPro]
GH25
Unannotated
Unannotated
Representative sequence (used for alignment): 5XE7n (308 AA)
Member sequence: A0A8S5NP18 (192 AA)
1 308 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ct2th6
[NCBI] 		2826606 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015209 [NCBI]
CDS location
range 5002 -> 5580
strand -
CDS
ATGAAAGTCATAGATATCTCAGACTGGAATGATCACATCAACTGGTCACATATGTTTGACAAAGGCGTAGAGGGTGTTATCGTAAAAATCAGTGAAGGGCGCACGCTCTCCGAGCTTCACGGGAAGCACATTTCGGCAGCCGCCGCACGCGGCCTCCCATGGGGCGTTTACTGCTACACGCACGCCCAGACCACAGAACGGGCGGAAGAAGAGGCGGCGGTCGTTATTGAAGCTCTGGAAGCCTTGGGATACGGTGCGCCGCCCTTGGGGATTTGGTTTGATGTAGAAGCCCCGGAAACGATCGGGCAGGACAGGGACGACGTGACCGCCATCTGTAGTGCCTTTATTTCCACATGCAACGCGACGGGATACGCTGCGGGCATCTATGCGAGCCTGTCCACCTTGACCGACTGCATGAACCTAGATGATCTAGCTGATTACGTGCCCACCTGGTGCGCCCAGTATAACGATGAATGCAGTTTCCATGACTATTTCCCTGGACGCATTCTGCAGGGCTGGCAATTCACGGATGCATTCGAAATTGACGGACGCAATTACGATATGAGCGAATGGTATTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5XE7n) rather than this protein.
PDB ID
5XE7n
Method AlphaFoldv2
Resolution 84.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50