Protein

Protein accession
A0A8S5N9H9 [UniProt]
Representative
4LOCD
Source
UniProt (cluster: phalp2_24503)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MANRRIGQAGLALIKQFEGCRLIAYQCSAGVWTIGYGHTVGVYKGMKITQKKAEAYLLQDVAKFEKYINNPSYVPFTDKLNQNQFDALVSFAFNLGQGNVKKLCTGRVMNQIPSAMQQYCKAAGKTLPGLQRRRKAEAALYNKKVESCTGATTTTVKETEDYNMNTIKKGSKGNAVKVWQIIIGTTPDGIFGSGTESVTKTWQKNHGLTADGIVGKNSWKAGLESL
Physico‐chemical
properties
protein length:226 AA
molecular weight:24745,2 Da
isoelectric point:9,69
hydropathy:-0,37
Representative Protein Details
Accession
4LOCD
Protein name
4LOCD
Sequence length
153 AA
Molecular weight
17182,25270 Da
Isoelectric point
4,60540
Sequence
MVITQEQAEQMLANDLGIYEAHVNNPALVPFTEQLNQNQFDALVSFCYNCGSGNLRGLCEGISIDEVPNVLPLYNKAGAKTLTGLVRRRQAEVDLYVKEVEPVLDKGVYQTIYNTWLKPSWDEAFAAKDTAQCDYIHWLAMELRKAAGVEEPE
Other Proteins in cluster: phalp2_24503
Total (incl. this protein): 3 Avg length: 201,7 Avg pI: 8,02
Protein ID Length (AA) pI
4LOCD 153 4,60540
A0A509EQQ2 226 9,76047
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13104
8kSiJ
 1 46,8% 96 8.126E-25
2 phalp2_37101
1bvx6
 877 50,0% 100 3.927E-21
3 phalp2_33221
5jbqV
 447 48,1% 106 4.835E-20
4 phalp2_4451
31DIk
 4919 43,2% 104 9.056E-20
5 phalp2_2632
6RhYr
 14867 47,6% 105 3.175E-19
6 phalp2_39267
4724r
 247 44,6% 103 7.293E-18
7 phalp2_31105
1YRHZ
 456 46,4% 99 7.293E-18
8 phalp2_14757
6QRn1
 45 42,4% 99 1.221E-16
9 phalp2_12161
6q0L8
 1 41,8% 98 7.977E-16
10 phalp2_23209
7Cg0p
 1 37,8% 103 1.091E-15

Domains

Domains [InterPro]
GH24
Unannotated
Disordered region
Representative sequence (used for alignment): 4LOCD (153 AA)
Member sequence: A0A8S5N9H9 (226 AA)
1 153 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct8hR1
[NCBI] 		2826172 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015113 [NCBI]
CDS location
range 18736 -> 19416
strand +
CDS
ATGGCAAATAGAAGAATCGGACAGGCTGGTCTTGCACTTATTAAACAGTTTGAAGGCTGCCGGCTGATAGCCTATCAGTGTTCTGCAGGTGTGTGGACCATTGGATACGGTCATACAGTGGGCGTATACAAAGGGATGAAGATCACACAGAAAAAGGCGGAGGCCTATCTGTTGCAGGACGTGGCGAAGTTTGAAAAGTATATTAATAATCCGTCCTATGTCCCATTTACAGACAAACTTAATCAGAATCAGTTTGATGCTCTGGTCAGCTTTGCTTTCAATCTGGGACAGGGCAACGTGAAAAAGCTGTGTACAGGCAGAGTAATGAATCAGATTCCGTCTGCAATGCAACAGTACTGTAAGGCTGCCGGTAAAACATTACCGGGATTACAGCGGAGAAGAAAAGCCGAGGCAGCCCTTTATAATAAGAAAGTAGAGAGTTGCACCGGTGCAACCACTACCACAGTGAAAGAAACGGAGGATTATAACATGAATACAATTAAAAAAGGCAGCAAGGGCAATGCAGTCAAGGTATGGCAGATCATCATCGGTACGACACCGGACGGCATTTTTGGCAGTGGAACGGAGAGTGTGACAAAGACCTGGCAGAAGAACCACGGACTGACGGCTGATGGAATTGTTGGAAAGAACTCTTGGAAAGCAGGGTTAGAGTCGTTATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4LOCD) rather than this protein.
PDB ID
4LOCD
Method AlphaFoldv2
Resolution 94.80
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50