Protein

Protein accession
A0A8S5N2X2 [UniProt]
Representative
HKFh
Source
UniProt (cluster: phalp2_35509)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MKKGFDISAWQEAENGTPYYDECHMQQAKEEGNEFVIIKLGENYNVDEFFEQHITAALSVGLEVGVYYFSHAYDEATAVQEAEWVINTLNSYGYTDYHLQAGIWYDYEEHRQLRNMINAGALTSQGMTNCISRFVNTLWSAGFQNVGVYSGYSLLWDETYAYSQMPSVPVWCAQYNSKCDYPNIRIWQYSDCGMVAGKEVDVNYMYD
Physico‐chemical
properties
protein length:207 AA
molecular weight:23898,1 Da
isoelectric point:4,39
hydropathy:-0,42
Representative Protein Details
Accession
HKFh
Protein name
HKFh
Sequence length
315 AA
Molecular weight
35854,11520 Da
Isoelectric point
4,47587
Sequence
MDKSAIINSIKKSYQSVRVANFHPTGILATRVLVLTMLVPILLVVIEYIMVFIQGYVSDDMNKLINVGINIIDHIFIPSVLTALVGFLALWIDKDGNGIPDKLEEQPKLPPLPNISAWQEDENGTPYYDDSHMQQAKEEGNEFVIIKLGENYNVDEFFEKHITAALNAGLEVGIYYFSHAYDEATAVQEAEWVINTLNSYGYTDYHLQAGIWYDYEEHRQLRNMINAGALTSQGMTNCISRFVNTLWSAGFQNVGVYSGYSLLWDETYAYSQMPSVPVWCAQYDSQCDYPNIRIWQYSDCGMVAGKEVDVNYMYD
Other Proteins in cluster: phalp2_35509
Total (incl. this protein): 2 Avg length: 261,0 Avg pI: 4,43
Protein ID Length (AA) pI
HKFh 315 4,47587
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_5939
6bh0H
 94 36,3% 209 3.651E-20
2 phalp2_22968
3mo9t
 23 28,5% 203 2.427E-09
3 phalp2_6607
1p0KW
 6 28,0% 214 9.135E-05

Domains

Domains [InterPro]
Unannotated
GH25
Representative sequence (used for alignment): HKFh (315 AA)
Member sequence: A0A8S5N2X2 (207 AA)
1 315 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudovirales sp. ctikv1
[NCBI] 		2826781 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015046 [NCBI]
CDS location
range 28912 -> 29535
strand -
CDS
ATGAAAAAAGGGTTTGATATTTCAGCATGGCAAGAGGCTGAAAACGGAACACCATATTATGATGAGTGCCACATGCAGCAAGCCAAAGAAGAAGGCAATGAATTCGTAATCATTAAATTAGGTGAAAACTATAACGTTGATGAATTCTTTGAACAACATATTACTGCAGCATTAAGTGTAGGCCTTGAAGTTGGTGTCTATTATTTTAGCCATGCATATGATGAGGCCACCGCAGTACAAGAAGCTGAATGGGTGATTAACACGCTCAATAGTTATGGATATACTGATTACCATTTGCAAGCAGGCATTTGGTATGACTACGAAGAACACCGCCAATTACGTAATATGATTAATGCAGGAGCACTAACTAGCCAAGGAATGACTAATTGCATTAGTCGGTTCGTAAATACATTATGGAGTGCAGGATTTCAAAATGTAGGTGTGTATAGTGGGTATTCACTGTTGTGGGATGAAACATATGCATATAGTCAAATGCCAAGCGTTCCTGTATGGTGTGCACAATATAATTCAAAATGTGATTATCCAAATATCAGAATATGGCAATATAGTGATTGTGGAATGGTAGCTGGCAAAGAAGTAGATGTCAACTACATGTATGACTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (HKFh) rather than this protein.
PDB ID
HKFh
Method AlphaFoldv2
Resolution 84.78
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50