Protein

Protein accession
A0A8S5MIQ0 [UniProt]
Representative
4L2Bj
Source
UniProt (cluster: phalp2_37848)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTRKGIDVSHWQGTIDWNKVKKAGIEFAIIKVGGSDAGFYTDSKWEANYKGAKAAGIPIGAYYFVGKDCVTASAGKADAERFLQILKGKQLEYPVYMDNEAQPASAKAGITEATIAFCETMEDAGYFVGIYGSAVSGFKERMDDTKLTPYAHWVAQYASKCSYKGDYGIWQYSSKGSVDGISGNVDMDYAYVDYPAIIQNGGFNGFTKAVSDDSKPATPAPVTPAKTVDELAQEVLDGKWGNGTDRKERLTVAGYDYSAVQAKVNALVKNQKSTPVYYTVKSGDTLSGIAKKYSTTVSAIQKLNPTLIKNVNLILTGWKIRVK
Physico‐chemical
properties
protein length:323 AA
molecular weight:35057,2 Da
isoelectric point:8,76
hydropathy:-0,33
Representative Protein Details
Accession
4L2Bj
Protein name
4L2Bj
Sequence length
294 AA
Molecular weight
33177,60100 Da
Isoelectric point
6,44034
Sequence
MELRGIDVSSWQGLIDWKKVKASGVVFAILKAGGSDAGRYKDRYFEKNYAEARANGIKVGAYYFNGRACTSYEAGRADANHFLSLISGKSFDYPCYSDLEAPTSATRNGNTDAVISFCETVKSAGYKAGVYASDISGFKDRLDMSRLSMYDKWVARYGSSPKYATVFQVWQYSSSGIIDGIKGKCDVDISYCDYSSPVIEVYNLWGADFAPVFNPEFYSNFYPDLKQAFGDDHSALWVHFQTFGMNEARQASAEFNVTKYRDRYPDLEKAYGDNLPLYYWHYCYFGKKEGRSGL
Other Proteins in cluster: phalp2_37848
Total (incl. this protein): 9 Avg length: 288,4 Avg pI: 5,93
Protein ID Length (AA) pI
4L2Bj 294 6,44034
3gYsx 295 5,74315
405cd 297 5,41280
410vv 293 4,92688
4OdXP 293 5,45316
4k73c 293 5,58781
4kqqi 299 5,69989
A0A345MZG2 209 5,32174
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3425
3TK4D
 923 48,2% 197 1.200E-62
2 phalp2_14409
4y7ED
 4 48,2% 201 1.466E-61
3 phalp2_22473
14QhF
 1 48,2% 195 1.273E-57
4 phalp2_26548
858CP
 728 43,6% 197 1.739E-57
5 phalp2_6199
5X5xO
 102 39,6% 207 4.622E-52
6 phalp2_34991
4Lee2
 2 33,1% 344 3.043E-46
7 phalp2_31512
3WNwM
 280 41,8% 208 1.271E-44
8 phalp2_29740
1rkWk
 100 36,7% 207 7.589E-41
9 phalp2_24035
8aWkT
 56 35,8% 212 7.589E-41
10 phalp2_529
o3Q8
 73 41,9% 205 1.035E-40

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 4L2Bj (294 AA)
Member sequence: A0A8S5MIQ0 (323 AA)
1 294 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctzto35
[NCBI] 		2826533 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014914 [NCBI]
CDS location
range 8655 -> 9626
strand +
CDS
ATGACGAGAAAAGGAATCGACGTCAGTCATTGGCAGGGAACTATTGACTGGAATAAGGTCAAAAAGGCCGGTATCGAGTTTGCCATCATCAAAGTTGGCGGCTCCGATGCCGGTTTTTATACGGATAGCAAATGGGAAGCAAATTACAAAGGCGCGAAGGCTGCCGGTATTCCCATCGGCGCTTACTACTTTGTCGGAAAGGACTGCGTAACTGCTTCCGCCGGAAAAGCAGATGCCGAGCGCTTCCTGCAAATCCTGAAGGGCAAGCAGCTGGAATACCCGGTCTACATGGATAACGAAGCGCAGCCTGCCTCTGCCAAGGCCGGAATCACTGAGGCCACCATTGCTTTCTGTGAAACTATGGAAGATGCCGGATACTTCGTCGGGATCTATGGCTCCGCTGTTTCCGGTTTCAAGGAGCGCATGGATGACACGAAACTCACGCCATACGCTCACTGGGTAGCGCAGTATGCGAGCAAATGCTCCTATAAGGGCGACTACGGCATATGGCAGTATTCTTCCAAGGGTTCTGTTGACGGCATCAGTGGTAATGTGGATATGGACTACGCCTATGTGGATTATCCTGCCATTATCCAGAACGGCGGCTTCAACGGCTTTACAAAGGCTGTGTCCGATGACAGCAAGCCTGCCACTCCTGCTCCGGTCACTCCGGCAAAGACCGTAGATGAGCTGGCGCAAGAGGTGCTGGACGGCAAATGGGGAAACGGAACTGACCGCAAAGAACGCCTCACCGTTGCCGGGTATGATTATTCTGCTGTGCAGGCAAAGGTCAATGCTCTGGTGAAAAATCAGAAATCTACTCCTGTCTACTACACCGTAAAAAGCGGTGATACCCTCTCCGGAATTGCTAAGAAATACAGCACCACGGTTTCGGCGATCCAGAAGCTCAACCCGACGCTCATCAAAAACGTCAACCTTATTCTGACCGGCTGGAAGATCAGAGTGAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4L2Bj) rather than this protein.
PDB ID
4L2Bj
Method AlphaFoldv2
Resolution 96.09
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50