Protein

Protein accession
A0A8S5MD37 [UniProt]
Representative
8qW5P
Source
UniProt (cluster: phalp2_40149)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MALHGCDVSTFQATMDFSEYDFVIIKSSEGINYQDEGMERHVQSALSTNTPFGFYHYARPDLGNTGAQEAASMLQYISPYIGQCVIALDWEQNSLSYPISWIEEFLNYILDKTGVHALLYIQANQATQSKYAPIANAGFGLWVAHWGVDEPSFSNWNTWSVWQYTDTPIDLDYFNGTVEDWNALAGGGVQLEWIYGNRYLTQSEMENNARLVWNYFGSLGWTLNAVAGMLGNMQRESTINPGIWQNLDPSQPSVLGYGLVGWTPGTRITNWLTSHGYELTSGEGQCAKIQEEWQHPEIEVVWLTTDEYPETFNEFVASHESPEYLASCFLYNYERAGVAAEDERRQNARNWYNFLSSFQVFVPRLDSDGIEGNPMWYDENPFYQAGYGMPNCTAYCWGRWYELLGEPPDLPLGDGNSWFPTAQEMGVYETGAYPGSMPALGAIICTYYDIGGHVAVVEQINEDGSIVTSNSGWQSTYFWTETLYPENGYVPSWADPGAYVQGFIYLPISYGPGPGPGPEPPEPEPPTYPSSRNFIYYLRNPWLHFLR
Physico‐chemical
properties
protein length:547 AA
molecular weight:61882,6 Da
isoelectric point:4,22
hydropathy:-0,39
Representative Protein Details
Accession
8qW5P
Protein name
8qW5P
Sequence length
366 AA
Molecular weight
41556,44150 Da
Isoelectric point
4,46882
Sequence
MALHGCDVSTFQATMDFSGYDFVIIKSSEGINYQDEGMERHVQSALSTNTPFGFYHYARPDLGNTGAQEAASMLQYISPYIGQCVIALDWEQKSLSYPISWIEEFLNYILDKTGVHALLYIQANQATQSKYAPIANAGFGLWVAHWGVDEPSFSNWNTWSVWQYTDTPIDLDYFNGTVEDWNALAGGGIQLEWIYGNRYLSQSEMENNARLVWNYFGSLGWTLNAVAGMLGNMQRESTINPGIWQNLDPSQPSVLGYGLVGWTPGTRITNWLTSHGYELTSGDGQCAKIQEEWQHPEIEVVWLTTDEYPETFNEFVSSHESPEYLASCFLYNYERAGVAAEDERRKNARNWYNFLSSSNLCATFRQ
Other Proteins in cluster: phalp2_40149
Total (incl. this protein): 4 Avg length: 391,5 Avg pI: 4,60
Protein ID Length (AA) pI
8qW5P 366 4,46882
86obd 364 4,59693
A0A8S5MCV8 289 5,11121
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25942
6nDNB
 33 80,2% 355 9.410E-194
2 phalp2_8864
2Qy89
 3 23,2% 258 2.103E-11
3 phalp2_13487
4NDwH
 1 22,8% 285 6.374E-04

Domains

Domains [InterPro]
GH25
Phage_lys2
Representative sequence (used for alignment): 8qW5P (366 AA)
Member sequence: A0A8S5MD37 (547 AA)
1 366 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF18013

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. cty0j11
[NCBI] 		2826592 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014877 [NCBI]
CDS location
range 10269 -> 11912
strand -
CDS
ATGGCGTTACATGGATGTGACGTTTCGACTTTCCAGGCCACAATGGATTTTTCCGAATATGATTTTGTAATTATAAAATCTAGTGAGGGAATAAACTATCAAGATGAAGGAATGGAAAGGCACGTGCAGAGCGCTTTATCTACCAACACGCCTTTCGGATTTTACCATTACGCAAGGCCAGATTTAGGCAATACAGGCGCACAAGAAGCCGCCAGTATGTTGCAATATATTTCGCCATATATTGGGCAATGCGTGATTGCATTAGACTGGGAACAAAATAGTTTGAGTTACCCTATTTCCTGGATAGAGGAATTTTTAAATTATATTTTGGATAAAACAGGGGTGCACGCCCTATTATACATCCAGGCTAACCAAGCAACGCAAAGCAAATATGCCCCTATTGCAAACGCCGGTTTTGGCCTATGGGTTGCGCATTGGGGGGTTGATGAGCCTAGTTTTAGTAACTGGAATACATGGTCAGTATGGCAATATACGGATACCCCCATAGACCTTGACTATTTTAATGGTACTGTAGAGGATTGGAACGCCCTTGCCGGTGGTGGTGTTCAATTAGAATGGATTTACGGTAACCGTTATTTGACACAATCGGAAATGGAAAATAATGCTCGTCTGGTATGGAATTATTTCGGCTCCCTTGGGTGGACATTAAACGCTGTTGCGGGTATGCTGGGGAATATGCAAAGGGAATCAACTATAAACCCCGGTATCTGGCAAAACCTAGACCCTTCCCAGCCTAGTGTTTTAGGCTATGGGCTTGTGGGGTGGACACCCGGCACACGTATTACAAATTGGTTAACTTCCCATGGATACGAATTAACTAGCGGTGAAGGGCAATGCGCTAAAATACAAGAAGAATGGCAACACCCGGAAATAGAAGTTGTATGGCTTACAACAGATGAATACCCAGAAACTTTTAACGAATTTGTTGCAAGCCATGAAAGCCCGGAGTATTTAGCAAGCTGTTTCCTTTATAACTATGAAAGAGCCGGTGTAGCCGCAGAGGATGAGCGAAGGCAAAATGCCCGAAACTGGTATAATTTTTTATCATCATTTCAAGTTTTCGTACCCCGTTTAGACAGTGACGGGATAGAAGGTAACCCCATGTGGTATGATGAGAACCCATTTTATCAAGCGGGTTACGGTATGCCAAACTGTACCGCCTATTGTTGGGGCCGGTGGTATGAACTTTTAGGCGAACCGCCTGATTTGCCTTTGGGGGATGGTAATTCATGGTTCCCCACGGCCCAGGAAATGGGGGTATACGAAACAGGAGCATACCCAGGAAGTATGCCAGCATTAGGCGCAATTATTTGCACCTATTATGACATAGGGGGCCATGTTGCTGTAGTCGAACAAATAAACGAGGATGGCAGTATAGTGACCTCTAATTCCGGTTGGCAATCCACCTATTTTTGGACAGAAACATTATACCCGGAAAATGGTTATGTTCCCTCTTGGGCAGACCCCGGCGCATATGTACAAGGTTTTATTTATTTGCCGATTTCCTACGGCCCAGGCCCAGGCCCAGGCCCAGAACCCCCGGAGCCAGAGCCGCCAACTTATCCGTCATCCCGTAATTTTATTTATTATTTGCGAAATCCCTGGTTGCATTTTCTACGCTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8qW5P) rather than this protein.
PDB ID
8qW5P
Method AlphaFoldv2
Resolution 92.68
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50