Protein

Protein accession
A0A8S5MBD9 [UniProt]
Representative
2miE5
Source
UniProt (cluster: phalp2_39105)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MIRKTKRMSAMTERYGIDISRAQGAIDWDVLAENKDLSFVILRATQGTAQDTRFADNIREVLRLDLPFGLYFAASAVTAQGVAAEADCAAEYVRQYKPRYGAWYDMELKSHRELGKDAITTLLRQWCDRVKEAGGRYGIYTNRDWLLNRIDLDRLPDALLWYAAYPSTARKTLAEAPKDNRQKLSFPQAALWQWSSAGRVDGIIGNVDLNVCYEDFPAEPTADKRYITLAEAKELLRAQGYDGIVI
Physico‐chemical
properties
protein length:246 AA
molecular weight:27913,3 Da
isoelectric point:6,63
hydropathy:-0,38
Representative Protein Details
Accession
2miE5
Protein name
2miE5
Sequence length
475 AA
Molecular weight
50822,04860 Da
Isoelectric point
7,54034
Sequence
MKFGFGKRIAGFVLAAAVAAGTFLSTPATAKAAAPLAKGIDVSKYQGAVNWSAVKNAGYSFAFIKAGSAKSGLDPYYAVNMAGATAAGMKVGVYIYSYATTVEGAMTEAQFAIAAMEPYSVSYPVVYDLEDSIHKNMSPDQLAALTVAFCSTVQQAGYYPMVYSSKNWMVGKIAATPYDKWIAQYNTVCEYPNPAFWQYSSSGVVAGINGSVDVNYQFKDYSNLIVANGFVDRAGGRYYYKNYRMQYGFIEDGGKRYFMNADGTLYKKGWLGDSLNMMYMDTKDGHMLTDLVEIGGKKYYFASNGLMQRGMIPLNGKIYLFGADGAMQYGFYSDQTAGTRYFKTDGSMAANELLTVGTNKYYFNTNGVMATGLTNIGGVTYLFGADGAMQYGWYTDASGMRYFQTNGAMAVNTTLAVGGVTYVFDANGLATAVPVINPATWVTDPATGVTIDTATGAVVPAETVAAAAAAAIAQK
Other Proteins in cluster: phalp2_39105
Total (incl. this protein): 4 Avg length: 447,3 Avg pI: 5,76
Protein ID Length (AA) pI
2miE5 475 7,54034
8qt62 534 4,38737
8rDIm 534 4,47342
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33489
7w448
 5 26,4% 306 1.424E-40
2 phalp2_36209
7jVrq
 19 25,9% 385 2.055E-31
3 phalp2_14321
3WKF2
 6 22,1% 466 1.871E-23

Domains

Domains [InterPro]
Disordered region
Choline_bind_3
Unannotated
Representative sequence (used for alignment): 2miE5 (475 AA)
Member sequence: A0A8S5MBD9 (246 AA)
1 475 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183|PF19127

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctRPH1
[NCBI] 		2826650 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014862 [NCBI]
CDS location
range 23606 -> 24346
strand +
CDS
ATGATCCGAAAGACGAAGAGGATGAGCGCCATGACTGAGAGGTATGGCATCGACATTAGCCGCGCGCAGGGCGCGATCGACTGGGACGTGCTGGCGGAAAACAAGGATCTGTCCTTTGTCATCCTCCGCGCGACGCAGGGGACGGCGCAGGACACACGCTTCGCGGATAATATCCGCGAGGTGCTGCGCCTGGACCTCCCCTTCGGGCTTTACTTCGCGGCGTCGGCCGTGACCGCTCAAGGCGTGGCCGCCGAGGCAGACTGCGCCGCGGAGTATGTCCGGCAGTACAAGCCCCGATACGGGGCCTGGTACGATATGGAGCTCAAAAGCCATCGAGAACTCGGTAAGGATGCGATCACGACACTGCTCCGGCAGTGGTGCGACCGTGTCAAAGAGGCCGGTGGCCGGTACGGCATCTATACCAACCGCGACTGGCTGCTGAACCGAATCGACCTCGACCGTCTGCCGGACGCGCTGCTGTGGTATGCAGCCTACCCGTCGACGGCGCGCAAGACGCTGGCGGAGGCGCCGAAGGACAACCGGCAGAAGCTGTCCTTCCCGCAGGCGGCTCTCTGGCAGTGGTCATCCGCCGGTCGCGTCGACGGGATCATCGGAAATGTGGACCTGAATGTCTGCTACGAAGACTTTCCGGCTGAACCGACCGCGGATAAGCGGTACATCACGCTTGCAGAAGCGAAAGAGCTCCTGCGGGCGCAAGGGTATGACGGCATCGTGATTTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2miE5) rather than this protein.
PDB ID
2miE5
Method AlphaFoldv2
Resolution 89.92
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50