Protein

Protein accession
A0A8S5LVI7 [UniProt]
Representative
7R6nR
Source
UniProt (cluster: phalp2_17460)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MAMSPALRNSVIAAISGGAIAIASVLITGPSGNDGLEGVSYIPYKDIVGVWTVCHGHTGKDIMLGKTYTEAECKALLNKDLATVARQINPYIKVD
Physico‐chemical
properties
protein length:95 AA
molecular weight:9946,4 Da
isoelectric point:6,70
hydropathy:0,27
Representative Protein Details
Accession
7R6nR
Protein name
7R6nR
Sequence length
139 AA
Molecular weight
N/A Da
Isoelectric point
9,51445
Sequence
MPPSLRKAVAAAIGGGAIAIASVLITGPSGNDGLEGVRHNPYKDIVGVWTVCYGHTGKDIIPGKTYTEAECKALLNKDLATVARQINRYIKVDIPETTRGALYSFVYNVGAGNFRTSTLXXXXKQVSGWMMLRSLITAL
Other Proteins in cluster: phalp2_17460
Total (incl. this protein): 59 Avg length: 132,9 Avg pI: 8,42
Protein ID Length (AA) pI
7R6nR 139 9,51445
1Lx47 120 6,21031
1bGQ3 154 8,67862
1bJy8 139 7,64015
1bUXr 122 8,96286
1bwFl 114 7,79579
1gwX1 124 9,48099
1hO5O 102 8,57966
1qkbh 154 6,71458
2X3M9 114 6,05065
2kVtD 142 9,19437
39xXu 106 6,70697
3OGpc 106 9,63901
3mqNn 129 8,90619
4XvoY 154 8,86661
4xYEU 154 9,06098
4zfUc 197 4,79115
6S9Oi 108 5,80794
72Fc1 122 8,58231
72HRe 122 8,95081
73FkM 130 9,14466
73SoJ 165 9,56300
75luD 128 7,76059
76FWj 118 6,24549
76uZZ 151 7,69909
76yvh 147 9,17026
790n8 134 9,14466
798SI 122 9,00212
7BRQg 149 9,72952
7PrgX 155 8,86964
7R4Gt 144 8,89788
7bRsz 165 9,34090
7dWVb 129 6,25692
7eNqt 143 8,44989
7fAym 134 9,16981
7fhkJ 138 5,71518
7fpAb 162 9,23092
7gs9i 109 9,00154
7hlWq 118 7,74820
7jWQC 136 9,38932
7kXns 119 9,47745
7lA69 132 8,92728
7lUz1 126 9,17077
7lV6h 126 8,92773
7mk1i 126 9,15272
7mkkg 135 8,79022
7nXsp 167 9,27437
7prOK 77 8,61609
7rWdW 157 8,66760
7vujm 118 8,54698
8Hivw 161 8,89685
8HkZN 113 9,39254
8zqRm 111 8,66121
X5Qn 122 8,60294
bYWs 159 9,29971
A0A6M5C909 193 9,10811
A5X378 116 9,42065
A0A8K1YSR8 92 7,74632
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_22286
7A6Fj
 714 64,8% 128 3.731E-53
2 phalp2_9410
8Hj1q
 5109 60,4% 86 2.108E-40
3 phalp2_17749
7tNIh
 28 56,0% 100 3.744E-36
4 phalp2_33221
5jbqV
 447 46,2% 93 5.837E-34
5 phalp2_2632
6RhYr
 14867 43,0% 93 1.414E-29
6 phalp2_4451
31DIk
 4919 38,5% 96 1.456E-26
7 phalp2_4305
8aoFg
 2477 38,6% 119 1.812E-25
8 phalp2_22738
7ZWXa
 59 37,7% 127 1.354E-22
9 phalp2_31530
48EM7
 20 38,6% 88 2.541E-22
10 phalp2_33347
6Ew8q
 73 36,4% 129 8.955E-22

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 7R6nR (139 AA)
Member sequence: A0A8S5LVI7 (95 AA)
1 139 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctrMZ4
[NCBI] 		2826477 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014747 [NCBI]
CDS location
range 1 -> 287
strand -
CDS
ATGGCAATGTCACCGGCACTACGAAATAGCGTAATAGCGGCGATAAGTGGCGGGGCTATTGCTATAGCATCTGTGTTAATCACTGGACCAAGTGGTAACGATGGCCTGGAAGGTGTCAGCTACATACCATACAAAGATATTGTTGGTGTATGGACTGTATGCCACGGACACACCGGAAAAGACATCATGCTCGGTAAAACGTATACCGAAGCAGAATGCAAAGCCCTCCTGAATAAAGACCTTGCCACGGTCGCCAGACAAATTAACCCGTACATCAAAGTCGATAT

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7R6nR) rather than this protein.
PDB ID
7R6nR
Method AlphaFoldv2
Resolution 81.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50