Protein

Protein accession
A0A8S5LGT4 [UniProt]
Representative
1HIrS
Source
UniProt (cluster: phalp2_29768)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTVGSVAARIARRICDQENVGYSQPDRRTWYANADWQGHVSSPQNADCSSLVCGAICYGIHDTYGAAWGHAALPEINDHWTGNMRQGLEARGFNEVPWNDSDLTPAGGFRVGDVILSAANEGGRGHVVIAVEDGGDPLVSEAWIAEDGSIDGYLGDSTGQETRTVRYSGHPHTQAGAWTSCHRFDEGKFLSQWPEFRKGQAAQAAPAAATTAAPAAPQHAHGIDISSHQAGLNVAGLWADFVIVKATEDNDYVNPYMVSQANSTLGASKRLGFYHFARPGDAAEQARYFVSAVGSFRGKATLWLDWEANAVEQGPGWAKTFLDTVRSLTGSTPGIYMNGSALNGYDWSAVASQYPLWYAGGPDYSDYGSSYSDPAVPNVSYWGAPLIHQYTEDGRLPGYNGTLDLNRLRDRASWDRMIGGGAVSSVAAQAASGEPQLSVDGEYGPATVGRLKSVMGAVGYEEVFAVANLRRFLNKAVPASSIHQLTGMYRLPEDRGWDSDMVEVFQYLVLAWNKPGVPAGWSFGDWVDGDFGEATISALQLALNASKANSFRLW
Physico‐chemical
properties
protein length:554 AA
molecular weight:59656,1 Da
isoelectric point:5,03
hydropathy:-0,31
Representative Protein Details
Accession
1HIrS
Protein name
1HIrS
Sequence length
277 AA
Molecular weight
29799,42340 Da
Isoelectric point
5,54131
Sequence
VTVQSVTAEIARRICDEQNVGYSQPERRSWYAAADAHGRVSSPQNADCSSLACGAISYGIHHTYKVPWGHAALLEINDYWTGNMRQGMESHGFNEVPWNDSDLTPAGGFQVGDIILSAANEGGVGHVVIAVEGGGDPLVSEAWIAEDGSIDGYAGDTTGSETRTVRYSSHPHTQRGSWTSCHRFSEAKFLQQWPAFAKWKAPTPAKPAAPASQTAAPQHAHGIDISSHQSGLNVAGIWADFVIVKATEDDDYVNPYMVSQANATLAASKRLGFYHFA
Other Proteins in cluster: phalp2_29768
Total (incl. this protein): 22 Avg length: 262,3 Avg pI: 4,88
Protein ID Length (AA) pI
1HIrS 277 5,54131
5NTMS 274 4,60000
5Yf2N 242 4,80491
6YTzv 278 4,53333
6YxWf 251 4,99918
6b9bC 283 4,83520
6mqZ9 236 4,69998
6oROX 260 5,02777
6qCy6 309 4,77228
6vwgD 260 4,58585
70sgF 167 4,76660
7MsS0 251 4,99861
7OfP6 160 4,37043
D9n4 219 5,13054
JQx3 165 5,00237
Kbtf 306 5,26547
oAHt 289 5,58207
oBlE 302 4,65713
rl6t 213 5,02249
zgLU 160 4,13426
A0A8S5P4Q2 315 5,11195
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_27631
6hhMB
 2 72,4% 189 8.970E-103
2 phalp2_29290
rl2U
 14 37,4% 195 6.299E-39
3 phalp2_40345
3lM8u
 52 32,4% 216 1.874E-26
4 phalp2_31215
8bqjy
 71 35,9% 178 6.874E-21

Domains

Domains [InterPro]
Unannotated
GH25
Representative sequence (used for alignment): 1HIrS (277 AA)
Member sequence: A0A8S5LGT4 (554 AA)
1 277 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. cte0t5
[NCBI] 		2823549 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014717 [NCBI]
CDS location
range 29660 -> 31324
strand -
CDS
GTGACCGTAGGAAGTGTGGCGGCGCGCATCGCCCGCCGAATCTGCGACCAGGAGAACGTCGGGTACAGCCAGCCCGATCGCCGTACCTGGTACGCGAACGCTGACTGGCAGGGGCACGTGTCCTCGCCTCAGAATGCTGACTGCTCAAGCCTCGTGTGCGGGGCGATCTGCTACGGCATCCACGACACCTACGGGGCGGCCTGGGGTCACGCCGCCCTGCCCGAGATCAATGACCACTGGACGGGCAATATGCGGCAGGGCCTGGAGGCTCGCGGCTTCAATGAGGTCCCGTGGAACGACTCGGACCTCACTCCGGCCGGCGGGTTCCGTGTCGGTGACGTGATCCTCTCCGCCGCGAACGAGGGCGGCAGGGGGCATGTGGTCATCGCCGTCGAGGATGGAGGGGACCCTCTCGTCTCTGAGGCGTGGATCGCCGAGGACGGGTCGATCGATGGCTACCTGGGCGACTCCACCGGCCAGGAGACGCGCACCGTCCGCTACTCCGGCCACCCCCACACCCAGGCCGGGGCGTGGACCAGCTGCCACCGCTTCGACGAGGGGAAGTTCCTGTCGCAGTGGCCCGAATTCCGTAAGGGGCAGGCCGCTCAGGCTGCGCCTGCGGCCGCCACTACCGCCGCGCCGGCCGCTCCGCAGCACGCGCACGGCATCGACATCTCCAGCCACCAGGCGGGCCTGAACGTGGCCGGGCTGTGGGCCGACTTCGTGATCGTGAAAGCGACCGAAGACAATGACTATGTGAACCCGTACATGGTCTCGCAGGCCAACTCCACGCTAGGGGCCTCGAAGCGGCTCGGGTTCTACCACTTCGCCCGCCCCGGGGATGCTGCGGAGCAGGCCCGCTACTTCGTGTCCGCCGTAGGCTCGTTCCGAGGCAAGGCGACTCTCTGGCTCGACTGGGAGGCGAATGCCGTCGAGCAGGGGCCGGGCTGGGCGAAGACCTTCCTCGACACGGTTCGGTCCCTGACCGGCTCCACGCCGGGCATCTACATGAACGGCTCGGCCCTGAACGGCTACGACTGGTCCGCCGTCGCCTCCCAGTACCCGCTCTGGTACGCGGGCGGGCCGGACTACTCGGACTACGGGTCCTCCTACTCGGACCCGGCAGTGCCGAACGTCTCCTACTGGGGCGCTCCGCTCATCCACCAGTACACGGAGGACGGCAGGCTGCCGGGCTACAACGGCACCCTCGACCTCAACCGCCTGCGCGACCGGGCCTCCTGGGACCGGATGATCGGTGGAGGGGCTGTCAGCTCAGTCGCTGCTCAAGCGGCTTCCGGCGAGCCTCAGCTCTCCGTCGACGGGGAGTACGGGCCGGCTACCGTCGGCCGTCTGAAGTCGGTCATGGGCGCCGTCGGCTACGAGGAGGTCTTCGCCGTCGCCAACCTGCGCCGGTTCCTCAACAAGGCGGTGCCGGCCTCCTCGATCCATCAGCTGACCGGCATGTACCGACTGCCGGAGGATCGGGGCTGGGACTCCGACATGGTCGAGGTCTTCCAGTACCTCGTGCTCGCTTGGAACAAGCCTGGAGTGCCGGCTGGCTGGTCCTTCGGGGACTGGGTAGACGGGGACTTCGGCGAGGCCACGATCTCGGCGCTCCAGCTCGCGCTGAACGCGTCCAAGGCCAACAGCTTCCGGCTGTGGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1HIrS) rather than this protein.
PDB ID
1HIrS
Method AlphaFoldv2
Resolution 93.13
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50