Protein

Protein accession
A0A8S5LF19 [UniProt]
Representative
MWc8
Source
UniProt (cluster: phalp2_23727)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 94% (predicted by ML model)
Protein sequence
TVGYGFLLAALTADELALNGGKYEPMSKETADKILELKLEKLTPAVFATFDWLKEKPQNVQEVVIEMAYQLGVSKVKKFVTTMHHIRAGEYRAAYQSGMNSLWAKQTPNRAKKVLSELLDN
Physico‐chemical
properties
protein length:121 AA
molecular weight:13576,6 Da
isoelectric point:8,78
hydropathy:-0,26
Representative Protein Details
Accession
MWc8
Protein name
MWc8
Sequence length
217 AA
Molecular weight
24224,29540 Da
Isoelectric point
5,26633
Sequence
MRYIAKGNICVKGNFVKEGETITLNQNEAKKYLDASMIEAFEETDSNTPPHDQGNPADQDDNLESKEEGGVSKMTLIEKIKENEGFSNKVYEDTLGYSTVGYGFLLAALTPDELALNGGKYEPMSKETADKILNLKLEKLTAAVFATFDWLKEKPQNVQEVVIEMAYQLGVLKVKKFVTTMHHIRMGEYEAAYQSGMNSLWAKQTPNRAKKVLGGLL
Other Proteins in cluster: phalp2_23727
Total (incl. this protein): 2 Avg length: 169,0 Avg pI: 7,02
Protein ID Length (AA) pI
MWc8 217 5,26633
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38350
zhyT
 51 56,2% 135 1.770E-38
2 phalp2_17008
8jNgs
 3526 36,0% 136 5.167E-17
3 phalp2_21661
31ima
 875 36,4% 140 7.023E-17
4 phalp2_24486
4I8GZ
 29 37,4% 139 9.544E-17
5 phalp2_19433
2QWcf
 9 33,5% 182 3.758E-15
6 phalp2_17182
3bGOC
 87 36,0% 133 1.274E-14
7 phalp2_27968
RI1z
 5083 37,6% 138 4.315E-14
8 phalp2_32797
2yPO8
 5731 33,8% 136 5.851E-14
9 phalp2_8442
12q1i
 28 33,5% 140 1.458E-13
10 phalp2_19234
42usC
 219 30,7% 140 1.655E-12

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): MWc8 (217 AA)
Member sequence: A0A8S5LF19 (121 AA)
1 217 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctJHU2
[NCBI] 		2823540 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014702 [NCBI]
CDS location
range 1 -> 366
strand +
CDS
ACCGTGGGCTACGGCTTTTTGCTTGCCGCGCTTACGGCCGACGAGCTAGCGCTAAACGGCGGCAAATACGAACCTATGAGCAAAGAGACGGCCGATAAAATTTTAGAGCTCAAACTTGAAAAACTTACTCCTGCAGTCTTTGCGACGTTTGATTGGCTAAAGGAAAAACCGCAAAACGTCCAAGAAGTGGTGATAGAAATGGCCTATCAGCTAGGCGTTTCAAAGGTTAAAAAATTCGTAACCACGATGCACCATATAAGAGCGGGCGAATATAGAGCCGCCTATCAAAGCGGCATGAATTCTCTTTGGGCGAAACAAACGCCGAACCGGGCAAAGAAGGTGCTAAGTGAGCTACTTGATAACTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (MWc8) rather than this protein.
PDB ID
MWc8
Method AlphaFoldv2
Resolution 83.98
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50