Protein

Protein accession
A0A8F3ECN3 [UniProt]
Representative
4YhxB
Source
UniProt (cluster: phalp2_39460)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTTYLNPEEPQWPTTQGFGMFPGGFNPVGGHTGRDKGTPTGRPLRAPADGVIKLAGNAGPWNTNPYWLEGSFAGLSVVLDTGAFAFTFNHLSKIMVTVGQKVKQGDVLALSGNSGGATSGSHHHFECMPDGWNFNNGTYGRINPDTVCKGYFNAPASVPLLPNQRLNGPQITRQRKEASTGSAIIREIPASQLEVWEGFVHGQKVTVNGFTSDVWFKDKVGYAWCGGFTSQSTAGLPDLTPRKALAANQRLTGPAGANQRKEAKTKAAVVREIPGNSVEIFTGFVRGEKVTVNGLTSDLWYVDAKGFAWAGGFTTQSVVGLPDLTVVAPPKPVPPAPAVPAFAYLNGIDVSTYQEAAALNTLSSDFYWIKASEGGGDFSDKDLASNVAEARLAGKPVGFYHFARPLVTAENTAAEEARSFLAVIRPHLQLGDVVALDWEAENQHRTDWALEWLTLVESAVGATPLIYLNAAAINGGDWAKVEAKYPLWYAGYGENLPVNGFVPPRTKPDVTWAAGVAAWQYTSKGRLSGYGGDLDLNIFYGTLEELRALGATRLLADPVPNPPVVTPDPPVADTDKDSNLEEFSQWVGSWLVENFNNRKK
Physico‐chemical
properties
protein length:600 AA
molecular weight:64484,6 Da
isoelectric point:5,70
hydropathy:-0,25
Representative Protein Details
Accession
4YhxB
Protein name
4YhxB
Sequence length
604 AA
Molecular weight
66163,60260 Da
Isoelectric point
4,77825
Sequence
MDYLNPEEPEWPVTQPYGMNPGGYNPSGGHTGRDKGTPVGRPLRAPGDGVITLAGNAGPWHSNIYWLEGSFAGLSVVLDCGPYAFTLNHLSEVLVSVNQRVSRGDIIARSGNSGGATSGPHHHFEVMPDKWNFQNGTYGRINPDTVCKSNWSGEPVVPAAPNQRRNGPQETMQRIEPKVDGKVWGDAGSNITRIIPPGQLEVFEGYVHGQSLTVNGFTSDIWYQDKIGFAWCGAFESQSTDGLPDLTPRRELAANQRRTGPEGAKQRDRAHRAGNVVREIPGGQVEVFTGYVHGEPVTLNGLSSNLWYVDAKGYAWAGAFESQDVVGLPDLTVPPPPSVITPPPPAVDFPHLNGIDVAVYQESAALNTLGADFIFIKASEGGAEWADKALASNVAEARLTGKPVGFYHFARPMLTPSNTAAEEACSFLNVIAPYLQDGDLLALDWEAENQHRTDWAEEWLDIVAAATEALPLVYLNADAINAHDWTQVEKRYPLWYAAYGANEVQEGFRPRSLQDAQVTWEAGVLLWQYASRGRLTGYDGDLDLNVFYGDAQLWRNLGAQGPLTEPEPNPPVVTPPPPITDDKDDSLTEFSEWLIQEFRNRKRE
Other Proteins in cluster: phalp2_39460
Total (incl. this protein): 8 Avg length: 560,4 Avg pI: 5,15
Protein ID Length (AA) pI
4YhxB 604 4,77825
3V3Ml 615 4,72886
4HQAj 611 4,87311
59NvO 604 4,78780
7dyQO 617 4,81088
fx2F 539 4,84782
A0A3G2KHR7 293 6,65666
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_27411
4LlKI
 22 37,6% 438 2.536E-85
2 phalp2_18562
757DT
 7 28,2% 569 5.456E-82
3 phalp2_30853
lLQH
 1 24,4% 569 1.616E-43

Domains

Domains [InterPro]
PET_M23
Unannotated
Unannotated
GH25
Disordered region
Representative sequence (used for alignment): 4YhxB (604 AA)
Member sequence: A0A8F3ECN3 (600 AA)
1 604 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage SilentRX
[NCBI] 		2836091 Silentrexvirus > Silentrexvirus silentrx
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW862992 [NCBI]
CDS location
range 17551 -> 19353
strand +
CDS
TTGACCACCTACCTCAACCCCGAAGAACCGCAGTGGCCGACCACGCAGGGCTTCGGCATGTTCCCGGGCGGGTTCAACCCCGTCGGCGGCCACACCGGACGCGACAAGGGCACCCCCACCGGCCGTCCCCTGCGCGCGCCGGCGGACGGCGTTATCAAGCTGGCCGGCAACGCCGGTCCCTGGAACACCAACCCGTACTGGCTGGAGGGCTCCTTCGCCGGACTCTCGGTGGTGCTGGATACCGGCGCGTTCGCCTTCACGTTCAACCACCTCTCGAAGATCATGGTCACGGTCGGCCAGAAGGTGAAGCAGGGCGATGTGCTCGCGCTCTCCGGCAACTCCGGCGGCGCCACCTCCGGCTCGCACCACCACTTTGAATGTATGCCCGACGGCTGGAACTTCAACAACGGCACCTACGGCCGGATCAACCCGGACACCGTCTGCAAGGGATACTTCAACGCCCCGGCCAGCGTCCCGCTCCTGCCCAACCAGCGCCTGAACGGCCCGCAGATCACCCGCCAGCGCAAGGAAGCGTCCACGGGCTCGGCCATCATCCGCGAGATCCCGGCGAGCCAGCTGGAGGTGTGGGAGGGTTTCGTCCACGGCCAGAAGGTCACGGTCAACGGCTTCACCTCCGATGTCTGGTTCAAGGACAAGGTCGGCTACGCCTGGTGTGGCGGTTTCACCAGCCAGTCCACCGCCGGGCTGCCGGACCTCACCCCGCGCAAGGCGCTCGCGGCGAACCAGCGGCTCACCGGCCCGGCCGGCGCGAACCAGCGCAAGGAGGCCAAGACCAAGGCCGCCGTCGTGCGCGAGATTCCCGGCAACAGCGTGGAAATCTTCACCGGCTTCGTCCGCGGGGAGAAGGTCACCGTCAACGGCCTGACCTCCGACCTCTGGTACGTCGACGCGAAGGGTTTCGCCTGGGCTGGCGGCTTCACCACGCAGTCCGTCGTCGGCCTGCCGGACCTGACCGTCGTCGCCCCGCCCAAGCCTGTGCCGCCGGCGCCGGCGGTCCCCGCGTTCGCCTACCTCAACGGCATCGACGTCTCCACCTACCAGGAGGCCGCGGCGCTGAACACGCTCAGCTCCGACTTCTACTGGATCAAGGCGTCCGAGGGCGGCGGGGACTTCTCCGACAAGGACCTCGCCTCCAACGTCGCCGAGGCCCGGCTCGCCGGCAAGCCGGTCGGTTTCTACCACTTCGCCCGCCCCCTCGTCACGGCCGAGAACACCGCCGCGGAGGAGGCCCGGTCCTTCCTCGCCGTCATCCGCCCGCACCTGCAGCTGGGGGATGTGGTGGCGCTGGACTGGGAGGCGGAGAACCAGCACCGCACCGACTGGGCGCTGGAGTGGCTGACGCTGGTGGAGAGCGCGGTGGGCGCGACACCGCTGATCTACCTCAATGCCGCTGCCATCAACGGCGGGGACTGGGCCAAGGTCGAGGCGAAGTACCCGCTCTGGTACGCCGGCTACGGGGAGAACCTGCCGGTCAACGGCTTCGTCCCGCCGCGCACCAAGCCCGACGTCACCTGGGCCGCGGGCGTGGCCGCCTGGCAGTACACCTCCAAGGGCCGGCTCTCCGGCTACGGCGGGGACCTGGACCTGAACATCTTCTACGGCACGCTCGAGGAGCTGCGCGCGCTGGGCGCGACCAGGCTGCTCGCCGACCCGGTCCCGAACCCGCCGGTGGTCACCCCGGATCCGCCGGTGGCCGACACCGACAAGGACAGCAACCTCGAGGAGTTCAGCCAGTGGGTCGGCTCCTGGCTGGTCGAGAACTTCAACAACAGGAAGAAGTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4YhxB) rather than this protein.
PDB ID
4YhxB
Method AlphaFoldv2
Resolution 85.82
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50