Protein

Protein accession
A0A8D6UFI2 [UniProt]
Representative
7zIOC
Source
UniProt (cluster: phalp2_16579)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MMNGIDISSYQTGIDLSKVTCDFVNIKATGGTGYVNPDCDRAFQQALSLGKKIGVYHFAHEKGLEGTPEQEGAFFLKNIQGYIGKAILILDFEGSNQKDSAWAKAFLDYVYNQTGIKPWFYTYTANLNTTDFSNVAKGDYGLWVAEYGRNLPQGYSQPSPPRTNNFPVVACFQYTSSGRLSGYNGNLDLNVFYGDQKTWDLYVGKKSDQTVPPENKIFDATSDEFIFTLTKGSTSVFYFDGKTIFELSDPTQLDHIRGTYNHVHGKEIPSLVWTPEQFDIYLKMYDKKPVYK
Physico‐chemical
properties
protein length:292 AA
molecular weight:32915,4 Da
isoelectric point:5,56
hydropathy:-0,45
Representative Protein Details
Accession
7zIOC
Protein name
7zIOC
Sequence length
299 AA
Molecular weight
33921,83490 Da
Isoelectric point
6,30813
Sequence
MTLFGIDISGWQAGINLSAVPTDFVIVKATGGTGYVNPDFKRQANQTLATNKLLGLYHFANDSGYQGTAIAEAEHFVNSVGDYLGKAVLVLDWEAENKANITWAREFLWHVHKLTGVKAWFYTYTFVLNAYDFSVLGNEGWPLWLADYPYSATQHGFAEYKQPSRRGFPYPAIAYQYSSTTILDGYGGHLDVNNFYGTQVDWLNYAKGNKVVAEQPKEKIKEVATMFCTYQEEGGNAIFYFDGKNVTVLAHEDEWQVLKMIYKANNDRDLPHFVFKEKAPFNKRLEHLVKRAVYPSLKA
Other Proteins in cluster: phalp2_16579
Total (incl. this protein): 8 Avg length: 305,8 Avg pI: 6,14
Protein ID Length (AA) pI
7zIOC 299 6,30813
3bWy6 301 9,70522
7BOav 312 5,56695
8pCxd 302 6,09839
8r0zA 308 5,72132
OTz1 323 4,69276
F0PIJ7 309 5,44202
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37341
8v6XY
 562 42,1% 223 1.119E-71
2 phalp2_24845
7umqo
 6 38,9% 236 3.862E-68
3 phalp2_4660
4CJrS
 5 37,1% 218 1.325E-64
4 phalp2_32821
2L8bh
 41 35,4% 223 8.664E-64
5 phalp2_4274
8cjfF
 9 41,5% 214 8.664E-64
6 phalp2_27394
4HDMm
 9 36,7% 215 2.706E-62
7 phalp2_12276
79roT
 46 40,0% 217 6.917E-62
8 phalp2_20117
23DDy
 70 43,3% 189 2.948E-60
9 phalp2_35154
5HNke
 1 35,8% 290 2.540E-56
10 phalp2_36024
5HOPw
 12 44,2% 217 3.749E-54

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 7zIOC (299 AA)
Member sequence: A0A8D6UFI2 (292 AA)
1 299 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterococcus phage Athos
[NCBI] 		2795669 Salasmaviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR990834 [NCBI]
CDS location
range 14624 -> 15502
strand +
CDS
ATGATGAATGGTATTGATATTTCTAGTTATCAAACAGGGATTGACCTTTCAAAAGTTACATGCGATTTTGTGAATATTAAAGCAACAGGGGGTACAGGTTACGTGAATCCTGATTGTGATCGAGCATTCCAACAAGCTTTGTCTTTAGGTAAAAAGATTGGTGTGTACCACTTTGCGCATGAGAAAGGCTTAGAAGGTACACCAGAACAAGAAGGAGCATTTTTCTTAAAAAATATTCAAGGTTATATTGGTAAAGCAATTCTAATTCTTGACTTTGAAGGTTCAAACCAAAAAGATTCAGCATGGGCGAAAGCGTTTCTTGATTATGTATACAATCAAACAGGTATTAAACCGTGGTTTTATACGTATACAGCAAACCTCAATACAACAGACTTTTCAAATGTAGCTAAAGGCGATTATGGTTTGTGGGTTGCTGAATATGGTAGGAATTTACCTCAAGGATATAGTCAACCTAGTCCACCACGAACAAATAACTTTCCAGTTGTCGCTTGTTTTCAATATACGAGTAGCGGTCGCCTATCTGGTTATAATGGAAACCTTGATTTAAATGTATTTTATGGAGATCAAAAAACATGGGATTTGTATGTTGGTAAAAAATCAGATCAAACTGTTCCTCCTGAAAATAAAATATTTGATGCTACAAGTGATGAGTTTATTTTCACCCTTACAAAGGGTAGTACAAGCGTGTTTTATTTTGATGGAAAAACGATCTTTGAATTGTCTGATCCAACGCAACTCGATCATATTCGTGGAACGTACAATCATGTACATGGAAAAGAAATCCCATCATTGGTGTGGACACCTGAACAGTTTGATATTTACTTAAAAATGTATGACAAAAAACCAGTATATAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7zIOC) rather than this protein.
PDB ID
7zIOC
Method AlphaFoldv2
Resolution 88.67
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50