Protein

Protein accession
A0A873WIT4 [UniProt]
Representative
4CAeh
Source
UniProt (cluster: phalp2_34945)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MLKAARKIAAPVVVRGAMLVSGLGIATITGHEGLERVGYLDSVGVPTVCYGHTRTAKVGVEFTQEQCEKLLQEDLAEFTATVNKYITVPLSQPQFDSLVSFCYNVGSYACRTSTMFRLINDGDYLGGAAQFDRWYRAGGRDCRIRSNNCYGVWTRRQAEKRLFLSGTSQHNAPLIPIVASGGNP
Physico‐chemical
properties
protein length:184 AA
molecular weight:20129,8 Da
isoelectric point:8,95
hydropathy:-0,11
Representative Protein Details
Accession
4CAeh
Protein name
4CAeh
Sequence length
70 AA
Molecular weight
7883,75510 Da
Isoelectric point
10,03252
Sequence
MFRLINDGDYLGGAAQFDRWYRAGGRDCRIRSNNCYGVWTRRQAEKRLFLSGTSQSNTPLIPIVASGGNQ
Other Proteins in cluster: phalp2_34945
Total (incl. this protein): 9 Avg length: 81,4 Avg pI: 9,35
Protein ID Length (AA) pI
4CAeh 70 10,03252
2g3at 70 8,97363
72WPy 50 9,05479
73G9f 50 9,05434
73GqO 89 9,41350
73w1J 90 9,26670
74kZ4 65 10,39116
7ytMY 65 8,97382
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1409
1poOc
 22 53,0% 49 2.246E-23
2 phalp2_19632
4jTZ6
 10 38,1% 55 1.730E-07
3 phalp2_1365
1dLHt
 2 38,4% 52 4.506E-07
4 phalp2_17438
7Fv8C
 39 38,4% 52 8.533E-07
5 phalp2_26702
2OTih
 81 35,2% 51 1.174E-06
6 phalp2_14837
7sNfr
 34 30,7% 52 3.060E-06
7 phalp2_33458
7emLn
 8 35,5% 45 2.863E-05
8 phalp2_33969
3OcoF
 6 41,1% 51 5.426E-05
9 phalp2_38857
1K6EI
 191 39,5% 48 7.002E-04

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 4CAeh (70 AA)
Member sequence: A0A873WIT4 (184 AA)
1 70 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Providencia phage PSTNGR1
[NCBI] 		2783542 Autographiviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW145136 [NCBI]
CDS location
range 27256 -> 27810
strand +
CDS
ATGCTTAAAGCAGCCCGTAAGATCGCTGCTCCTGTTGTAGTCCGTGGCGCGATGCTCGTGTCCGGTCTCGGTATTGCTACCATTACCGGGCATGAGGGTCTTGAGCGGGTAGGCTACCTCGATTCTGTCGGGGTTCCTACCGTCTGCTACGGCCATACCCGCACTGCTAAGGTGGGTGTAGAGTTCACCCAAGAGCAGTGTGAGAAGCTACTACAGGAAGACCTAGCCGAGTTCACCGCTACGGTCAACAAATACATCACAGTCCCACTGAGCCAGCCTCAGTTCGACTCCCTAGTGTCCTTCTGCTACAACGTAGGCTCTTATGCTTGTCGGACGAGTACCATGTTCCGCCTCATTAATGATGGCGATTACCTCGGTGGTGCAGCACAGTTTGATCGTTGGTATCGTGCCGGCGGTCGTGACTGCCGTATCCGGTCCAATAACTGCTATGGTGTCTGGACTCGTCGTCAGGCAGAGAAGCGGCTGTTCCTCAGCGGGACTAGCCAGCACAACGCACCCTTAATCCCTATCGTTGCCTCTGGAGGTAACCCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4CAeh) rather than this protein.
PDB ID
4CAeh
Method AlphaFoldv2
Resolution 85.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50