Protein

Protein accession
A0A873WHD4 [UniProt]
Representative
7tNIh
Source
UniProt (cluster: phalp2_17749)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSLKQKLTVLVSAGATAIALTVIAHFEGVRYEPYEDVGGVLTVCYGHTGKDIIPNKVYSKDECNELLESDFQRTKQQVDKLVKVPTDDYTKAALYSFAFNVGTGSFAKSTMLKKLNAGDQYGACEELKKWVYAGGKVWRGLVNRREAEAAICHGSL
Physico‐chemical
properties
protein length:156 AA
molecular weight:17145,4 Da
isoelectric point:8,28
hydropathy:-0,20
Representative Protein Details
Accession
7tNIh
Protein name
7tNIh
Sequence length
95 AA
Molecular weight
10528,91170 Da
Isoelectric point
5,68614
Sequence
MNLKQKVTAVASAGAVSIALTVIGYFEGVRYEPYRDVAGVLTVCYGHTGNDIIQGKTYTQQECDELLQKDFIRTQQQVDILVKVPVDDKTKASLY
Other Proteins in cluster: phalp2_17749
Total (incl. this protein): 28 Avg length: 114,9 Avg pI: 7,92
Protein ID Length (AA) pI
7tNIh 95 5,68614
1FRED 82 6,69890
1Mz0M 92 7,66226
1iXpX 95 6,70606
1jboj 99 6,02655
3dDgh 93 7,72740
3s1PF 116 6,70361
4gKAg 108 5,66278
7BAGr 100 5,68580
7bR8N 114 9,88076
7mAcv 107 6,70231
7mGZ5 80 9,19927
7mGZO 70 8,88460
7mH7u 80 9,46791
7oYZK 127 9,41530
7sWEG 70 9,65287
7vpTm 122 8,56367
8byH4 138 8,44860
8lGRl 113 7,76804
wwPC 85 8,55317
x2EC 93 5,69250
A0A2H4P731 167 8,90497
A0A7L7SY05 165 8,74070
A0A3G8FE84 156 8,32688
A0A9E6YDS0 165 8,74070
A0A9E7CC13 165 9,16639
A0AAU6W0G9 165 8,74070
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17460
7R6nR
 59 48,0% 100 7.535E-38
2 phalp2_20985
7xCJE
 9 47,7% 67 3.901E-23
3 phalp2_745
1OLeh
 3 34,7% 72 1.247E-17
4 phalp2_13437
4E7GA
 1 59,6% 57 1.711E-17
5 phalp2_31530
48EM7
 20 40,5% 74 2.507E-14
6 phalp2_26644
2b0IA
 24 41,5% 65 3.442E-14
7 phalp2_9110
5HBET
 95 28,7% 80 2.120E-12
8 phalp2_37777
4xRBI
 75 38,2% 81 3.995E-12
9 phalp2_35600
1fedL
 106 44,6% 65 5.485E-12
10 phalp2_36653
3MLYp
 41 32,2% 96 3.673E-11

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 7tNIh (95 AA)
Member sequence: A0A873WHD4 (156 AA)
1 95 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Providencia phage PSTCR3
[NCBI] 		2783545 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW057855 [NCBI]
CDS location
range 30328 -> 30798
strand +
CDS
ATGTCACTCAAGCAAAAACTAACTGTGCTTGTTAGCGCAGGGGCTACGGCTATCGCTCTAACAGTCATTGCGCATTTTGAAGGTGTTAGATATGAGCCTTATGAAGACGTGGGTGGTGTACTGACGGTTTGTTATGGCCACACAGGAAAGGACATCATTCCTAATAAAGTTTATTCAAAAGATGAATGTAATGAATTGCTTGAGTCAGACTTTCAGCGCACTAAACAGCAGGTAGATAAACTGGTTAAGGTGCCAACAGACGATTACACCAAAGCCGCACTGTATTCATTCGCTTTTAACGTTGGTACTGGCTCGTTCGCTAAGTCGACAATGCTTAAAAAGCTAAATGCAGGTGACCAATATGGTGCCTGTGAAGAACTAAAAAAGTGGGTTTATGCTGGTGGTAAGGTATGGCGTGGACTTGTAAACCGCAGAGAAGCGGAGGCAGCTATATGTCATGGAAGCCTATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0020002 host cell plasma membrane cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7tNIh) rather than this protein.
PDB ID
7tNIh
Method AlphaFoldv2
Resolution 95.94
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50