Protein

Protein accession
A0A6J7WQU2 [UniProt]
Representative
6ytwW
Source
UniProt (cluster: phalp2_4929)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MPADLNNIPFVPARWYTNGRSSQVTMIVIHDMEAGEYSTTAESCANYFSNTSVQASAHYCADNDSVVCAVQPDDEAWHTGHGPTNHCSVGIEQAGYANQGADGWADDYSQSMIKGQVAPLAAALCQRYGIPVQFLNSDDLRAGNYSGITTHREITYAFVQGGHTDPGPDYPVDELISAIAAELGGTVSPSHPPYPAPISDVYTIGSTGSKVTQIQKLVGVDQDGVYGPNTASAVQSWQRNIQVPADGVWGPRTQEATDQFFTWLASNQHPTEPANGNSFLSALAGAMSQVLSSGSSGGAVMIAQNSLNAKGYTLTVDGVFGPQTDAAVRKFQQDRQLTADGIIGPQTWSALVS
Physico‐chemical
properties
protein length:353 AA
molecular weight:37367,6 Da
isoelectric point:4,53
hydropathy:-0,28
Representative Protein Details
Accession
6ytwW
Protein name
6ytwW
Sequence length
354 AA
Molecular weight
37470,36460 Da
Isoelectric point
4,98418
Sequence
MAFYLLDNPPATKQFYPSRNNGWQGGIVIHTTEGVGGYDSAENTAAYIARRTTPGSYHAIADLDGIVWLMPITYSAFGVAASGYNSTCVQIAIAARSADLDLGNGYTPTEIDFMAQAIVQAWREANFDPMQGLAFIGDGVKYGQGLAHHGDVQPADRSDAWSRSANRAEFDAYLLQRIAAHAGGAAPVAPPFAPPAPPADSVWRVGSTGDKVRQIQGLIGVPADGIFGPQTEAAVRQWQSNLQLVADGVWGPQTEEATNNLFAFLANLPAVQEINPNNPFLQSLNDALSSVLRSGSTGDSVKILQTGLNGKGYPLVGDGVFGPQTDAAVRRFQADRGLRVDGVVGPKTWAALVS
Other Proteins in cluster: phalp2_4929
Total (incl. this protein): 46 Avg length: 332,3 Avg pI: 5,14
Protein ID Length (AA) pI
6ytwW 354 4,98418
18FxC 358 4,83344
1JrBI 351 4,72772
1KiLQ 354 4,50468
1L72K 308 5,27718
1O1tq 370 4,49047
1qlmW 357 5,16748
240CJ 293 5,77964
24zZf 354 4,88624
27L4q 357 5,00464
28y4C 266 6,11908
2ZD3n 355 4,59443
30c6X 355 4,83793
477iL 352 4,97133
49yXs 352 4,72567
4F7dP 255 5,67551
4b6UT 357 5,34528
4psjA 352 4,94848
4pvu8 355 5,57292
4rc8F 358 4,86248
50TVd 220 5,32589
52rcP 352 5,39450
56lhM 355 5,76804
5aBM1 286 5,12502
5aInc 352 4,83600
5bIm0 350 5,09933
5d2r1 357 5,57922
5fVqX 374 5,21722
5fzbf 357 5,39620
5gFBG 355 5,18425
5gTJQ 352 4,69464
5h0wH 352 4,69339
5h5vf 286 5,88041
5iCZC 218 6,05696
5ijOX 352 4,56800
5mkqE 354 4,96798
6xLqX 354 5,15219
7K8IZ 286 5,51937
806Nl 289 4,98997
806al 362 5,28520
80oFB 289 4,87999
86q5T 269 4,95303
8mU2y 359 4,88465
JxRJ 352 5,24638
xgbS 290 5,94032
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8051
5Ickg
 15 28,1% 380 2.116E-24
2 phalp2_31913
4N8u3
 4 27,3% 300 9.410E-24
3 phalp2_4005
10KQf
 1 27,8% 330 2.663E-21
4 phalp2_22201
6VaYI
 26 25,5% 329 6.468E-21
5 phalp2_17898
EGF4
 130 24,0% 353 2.335E-18
6 phalp2_184
5Dm5y
 192 24,2% 342 4.477E-16
7 phalp2_13713
6Ajj7
 6 25,9% 258 1.431E-15
8 phalp2_7313
4e1GY
 5 22,4% 343 6.156E-14

Domains

Domains [InterPro]
Unannotated
PG_1
PG_1
Representative sequence (used for alignment): 6ytwW (354 AA)
Member sequence: A0A6J7WQU2 (353 AA)
1 354 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798283 [NCBI]
CDS location
range 33401 -> 34462
strand -
CDS
ATGCCTGCCGATCTAAACAACATCCCGTTTGTTCCAGCCCGTTGGTACACCAATGGACGTTCTTCACAGGTAACCATGATCGTGATTCACGACATGGAAGCCGGTGAGTACAGCACCACCGCAGAATCTTGTGCCAACTACTTTTCGAACACTTCTGTTCAGGCTTCGGCCCATTACTGTGCTGACAATGATTCTGTGGTGTGTGCTGTTCAGCCTGATGACGAGGCTTGGCATACTGGTCACGGACCTACCAACCACTGTTCAGTAGGCATTGAGCAGGCTGGTTATGCCAACCAAGGCGCTGACGGGTGGGCAGATGACTATTCGCAGAGCATGATCAAGGGTCAGGTAGCACCTCTTGCTGCTGCTCTCTGCCAGCGTTACGGCATTCCGGTACAGTTCTTGAACTCCGACGACCTTCGTGCAGGCAACTATTCGGGGATCACGACTCACCGTGAGATTACCTACGCATTTGTTCAAGGTGGCCATACCGATCCCGGTCCTGATTACCCAGTTGACGAGTTGATCAGCGCCATTGCTGCAGAACTCGGTGGGACTGTTTCTCCTTCTCATCCCCCGTACCCTGCCCCAATCAGCGATGTGTACACCATTGGCTCCACTGGTTCAAAAGTGACACAGATTCAGAAGTTGGTAGGCGTTGATCAGGATGGTGTTTACGGTCCTAACACGGCCAGTGCTGTGCAGAGTTGGCAGCGAAACATTCAAGTCCCTGCTGACGGTGTATGGGGTCCACGAACACAAGAAGCAACCGACCAGTTCTTCACGTGGCTTGCATCTAATCAGCACCCAACAGAACCTGCTAATGGCAACTCGTTCTTGTCCGCTCTTGCTGGTGCAATGAGCCAAGTCCTCAGCAGTGGCTCAAGTGGTGGAGCAGTGATGATTGCTCAGAATAGCCTGAATGCTAAGGGCTACACCCTCACTGTTGACGGTGTGTTCGGTCCTCAGACTGATGCAGCAGTTCGTAAGTTCCAGCAGGATCGCCAACTGACTGCTGATGGAATCATCGGACCACAAACGTGGTCTGCACTAGTGAGTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6ytwW) rather than this protein.
PDB ID
6ytwW
Method AlphaFoldv2
Resolution 76.62
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50