Protein

Protein accession
A0A6J7WND2 [UniProt]
Representative
6Rxhb
Source
UniProt (cluster: phalp2_18518)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MDLKQQLIREEGAESCAYQDSLGYWTIGVGRLIDSRKGGGLSNEEIDMLLDNDIKRNYEAVLAALPWMEKLSDQRQAVLIEMAFQMGVSGLLQFKRTLGSIEDGQYGEAAVEMLESKWAQQTPKRAYRMALQMETDEWQ
Physico‐chemical
properties
protein length:139 AA
molecular weight:15826,8 Da
isoelectric point:4,59
hydropathy:-0,47
Representative Protein Details
Accession
6Rxhb
Protein name
6Rxhb
Sequence length
222 AA
Molecular weight
24001,24760 Da
Isoelectric point
6,11556
Sequence
MTMLLTDAERAAVRAQLRVDEGFVSHAYQDSLGYWTIGIGRLIDKRKGGGITEDEAEMLLEHDLAKVEGELLGELPWVAGLDGVRKQVLANMAFNMGMPTLRTFRATLAAIKAGDYVKAADQMAVSKWHFQVGARAVRLEAMMRTGKTGGATLPHIEASISALQSALNRLGAKPRLRVDGDLGPLTAEAVRRFQSANGLVTSGIADGDTWERIRDALAELDA
Other Proteins in cluster: phalp2_18518
Total (incl. this protein): 4 Avg length: 162,3 Avg pI: 7,31
Protein ID Length (AA) pI
6Rxhb 222 6,11556
A0A6G5QAI7 146 9,18489
A0AAE9VEW1 142 9,34000
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17008
8jNgs
 3526 55,9% 134 8.655E-51
2 phalp2_16834
1uDRT
 24 50,0% 138 9.461E-43
3 phalp2_32797
2yPO8
 5731 50,7% 138 3.314E-42
4 phalp2_14448
4FjnP
 18 47,1% 142 9.086E-37
5 phalp2_27968
RI1z
 5083 46,3% 138 6.433E-34
6 phalp2_9780
80F6A
 154 43,7% 135 1.459E-32
7 phalp2_7697
6I6lz
 232 42,4% 153 3.720E-32
8 phalp2_22190
6RxcX
 29 43,4% 152 3.720E-32
9 phalp2_6928
2KMCh
 358 37,1% 159 2.925E-30
10 phalp2_38350
zhyT
 51 34,8% 149 4.507E-26

Domains

Domains [InterPro]
GH24
PG_1
Representative sequence (used for alignment): 6Rxhb (222 AA)
Member sequence: A0A6J7WND2 (139 AA)
1 222 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798241 [NCBI]
CDS location
range 8964 -> 9383
strand -
CDS
ATGGATTTGAAGCAGCAACTGATACGCGAGGAGGGCGCCGAGTCCTGCGCATACCAAGACAGCCTCGGCTACTGGACCATCGGCGTGGGCCGCTTGATTGACTCGCGCAAGGGCGGCGGCTTGTCGAACGAAGAAATCGACATGCTGCTGGACAACGACATCAAGCGCAACTACGAGGCGGTACTGGCTGCGCTACCGTGGATGGAGAAGTTGTCTGACCAGCGACAGGCGGTGCTGATCGAGATGGCGTTTCAGATGGGCGTCAGCGGTCTGCTTCAGTTTAAGCGCACGCTGGGTTCCATCGAGGATGGTCAGTATGGCGAGGCTGCGGTGGAGATGCTGGAGAGCAAGTGGGCACAGCAGACGCCTAAGCGAGCGTACAGGATGGCGTTGCAAATGGAGACTGACGAATGGCAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6Rxhb) rather than this protein.
PDB ID
6Rxhb
Method AlphaFoldv2
Resolution 89.58
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50