Protein

Protein accession
A0A6J7WI72 [UniProt]
Representative
5D403
Source
UniProt (cluster: phalp2_22061)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVSKRSIDLILDSEGCDLSPSWPGGASGVTYGHGFDLGYNSEEQIKRDWSAHVNGNVLAFMVSCAGVKGETAKKRITPQTRVLKITSDAAREVFENRTLPRFIKLAQDTYPGFDELNEDTRGALVSLVFNRGSAFGVEGQPSWESRREMRELAPLILAKDYEGIAATIKAMGRLWVGKGLDGLIARRHAEAALCIDS
Physico‐chemical
properties
protein length:197 AA
molecular weight:21560,2 Da
isoelectric point:6,32
hydropathy:-0,26
Representative Protein Details
Accession
5D403
Protein name
5D403
Sequence length
141 AA
Molecular weight
15763,14790 Da
Isoelectric point
9,46700
Sequence
MISKKSIDLIIKHEIGGREVYTKKYERPIWAGGESGITIGIGADLGYTTEKQFMLDWSGAINLNFINALRPTIGIKGPQAKAMLKGEILNVRIPYNTAYEVFVKSSLPRYYAMTKKIYPNMDLLNDDTKGALVSVVYNRGN
Other Proteins in cluster: phalp2_22061
Total (incl. this protein): 92 Avg length: 200,5 Avg pI: 8,24
Protein ID Length (AA) pI
5D403 141 9,46700
193JA 201 8,59533
19Gfn 228 5,88115
19Hdy 119 9,43928
1JMIC 200 8,90471
1JR7v 201 8,90471
1K3lr 214 9,07800
1Khej 201 8,82645
1LGcW 201 8,75089
1Lgnv 201 7,68846
1LhgK 201 6,85645
1Ll8A 201 8,76398
1MH2K 201 8,85623
1Ms0j 200 8,94932
1aHkt 201 8,88698
1aQFb 201 8,37053
1oYcY 201 7,71756
24AhS 200 8,51120
25g0x 236 6,26317
2arDi 201 8,88737
2qn3d 201 7,65874
30LI2 201 8,36079
316UX 214 7,53602
31NQI 201 8,37046
31YAd 201 8,42661
31yrF 236 6,25868
32O3P 236 6,92591
32cki 201 8,57992
32x5M 201 8,35144
33ysA 201 8,44776
37ww7 201 8,61215
3bnGK 201 8,36086
41GLy 210 9,08200
45RKZ 201 8,90420
463SP 201 7,73211
47Dco 201 8,45956
48FQd 201 7,66345
4NngB 204 9,07807
4V9L9 201 8,76378
4bq30 117 8,60629
4qNCn 201 7,70586
50zTl 120 9,27708
51uBh 201 8,37053
51uOZ 201 8,49869
52AQf 201 8,36073
52j5k 201 7,64862
55MlE 201 8,61196
55qOe 201 8,59546
56Mdx 201 8,66934
56NXW 201 8,59552
58vYd 201 8,84069
5BIsY 201 8,37053
5BPBP 201 8,69164
5CDz1 201 8,90381
5cpGF 183 8,79131
5fk5z 201 8,57979
5gb0P 201 8,68030
5hmoh 201 8,62898
5l710 201 8,96338
5nmsV 201 8,37053
5ocf3 201 8,37046
5u5jZ 201 7,64896
5u7Ut 201 8,35125
5wVmX 201 8,39238
5yzNU 201 8,69164
6GXs5 201 8,36066
6IDp8 200 8,40128
6LCMW 201 7,73808
6UB9W 201 8,36079
6xYaE 201 8,77739
6xbgX 201 8,40283
7FG8C 214 5,27758
7G5eC 236 8,20239
7Kc3i 211 9,06853
7WHov 201 8,76417
84FiM 201 7,72905
84uQh 201 7,65857
8Foa 201 8,43487
8jMv2 201 6,62381
8keIl 201 8,36066
8mc7h 201 7,65857
8rqBb 201 9,00025
Cf5c 213 9,08148
Ix8c 234 9,16594
JIfH 203 7,77800
KVlu 201 8,37053
LJlS 203 7,77755
Sw4v 201 7,71557
dVmC 214 6,18882
A0A6J5KI23 197 6,32791
A0A6J7WL82 201 8,48586
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_35257
6Mntu
 167 75,1% 141 5.718E-84
2 phalp2_36119
6KcGh
 69 47,1% 104 2.384E-27
3 phalp2_2103
3b6jS
 1 26,4% 102 2.082E-08
4 phalp2_9774
816p5
 4 24,1% 124 5.452E-04

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 5D403 (141 AA)
Member sequence: A0A6J7WI72 (197 AA)
1 141 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798247 [NCBI]
CDS location
range 22089 -> 22682
strand -
CDS
ATGGTAAGCAAACGCTCAATCGATTTAATACTTGATTCCGAAGGTTGTGACCTTTCGCCTTCGTGGCCAGGTGGTGCGAGTGGCGTCACTTACGGACACGGATTTGATTTAGGTTATAATTCAGAGGAACAAATCAAACGCGATTGGTCGGCTCACGTTAACGGAAACGTTTTAGCGTTTATGGTTTCTTGTGCGGGTGTTAAAGGCGAAACGGCAAAGAAACGCATCACACCGCAAACAAGGGTATTAAAAATCACTAGCGACGCAGCGCGCGAAGTGTTTGAGAATAGAACACTACCAAGATTTATCAAATTAGCACAAGACACATACCCAGGGTTTGACGAATTGAACGAAGACACACGCGGCGCGTTAGTATCGCTTGTGTTTAATCGCGGATCAGCGTTTGGCGTAGAAGGTCAACCGTCTTGGGAATCACGTCGCGAAATGCGTGAACTGGCGCCGCTTATCTTGGCGAAAGATTACGAGGGGATAGCGGCTACAATTAAGGCAATGGGTCGCTTGTGGGTTGGCAAAGGTCTTGATGGTTTGATTGCTCGCCGTCACGCGGAAGCCGCGCTTTGTATAGATTCATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5D403) rather than this protein.
PDB ID
5D403
Method AlphaFoldv2
Resolution 89.45
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50