Protein

Protein accession
A0A6J7W8D3 [UniProt]
Representative
53jIP
Source
UniProt (cluster: phalp2_16295)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MATKSRVAVASLALSASALVGIAVNEGYIGQAYKDVVGVPTIGFGETQGVTPGQKTDPVRALVKLEASASSIAQAMAACIQVPISQNEYDAYVSFSYNLGPGTFCKYIAPVLNKPDYEGACKKILLFDHAGGKKYPGLTRRREEESQKCLGLD
Physico‐chemical
properties
protein length:153 AA
molecular weight:16192,4 Da
isoelectric point:8,31
hydropathy:-0,02
Representative Protein Details
Accession
53jIP
Protein name
53jIP
Sequence length
100 AA
Molecular weight
10699,15700 Da
Isoelectric point
6,25260
Sequence
MKARIVIGALTLSASALVGIAVHEGYRGEAYRPVPGDVPTIGFGTTDGVKPGDTIEPVQALVRKLADVQRFEGALQQCVRVPLHQHEYDAFLSLAYNIGP
Other Proteins in cluster: phalp2_16295
Total (incl. this protein): 19 Avg length: 126,7 Avg pI: 8,05
Protein ID Length (AA) pI
53jIP 100 6,25260
2qtob 111 6,06605
3hBuk 129 7,76190
4BWhS 113 7,78451
4Mu9K 100 8,09531
5cIgh 157 9,23028
5fdOX 78 7,90900
5uJRl 152 9,38300
5xZRP 184 8,85514
6Uf7V 191 9,02823
6x6si 92 9,50936
7WRQH 83 6,71509
7g3Eo 184 9,06014
84qr3 98 6,70634
8p5pv 98 7,82267
L8FU 152 8,99935
aRGY 99 6,90084
nOHD 134 8,57902
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1991
4GrLi
 1 57,1% 77 2.063E-24
2 phalp2_15013
71l0d
 13 40,1% 102 2.130E-17
3 phalp2_19746
4T5j9
 1 35,3% 99 4.013E-17
4 phalp2_26644
2b0IA
 24 49,3% 75 9.522E-16
5 phalp2_24578
4ZJqY
 9 37,0% 89 1.100E-13
6 phalp2_36488
1js3Z
 12 41,6% 84 1.100E-13
7 phalp2_31530
48EM7
 20 41,3% 92 7.354E-13
8 phalp2_13608
5ojL2
 3 38,0% 92 1.743E-11
9 phalp2_37312
8djZH
 4 41,1% 85 2.392E-11
10 phalp2_30834
fSv9
 1 42,8% 63 1.597E-10

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 53jIP (100 AA)
Member sequence: A0A6J7W8D3 (153 AA)
1 100 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798201 [NCBI]
CDS location
range 23354 -> 23815
strand -
CDS
ATGGCAACCAAGTCACGCGTAGCGGTAGCCAGTCTGGCATTGTCTGCTTCGGCCTTGGTGGGTATCGCCGTTAATGAGGGTTATATCGGTCAGGCATATAAGGATGTAGTCGGTGTCCCGACGATTGGGTTTGGTGAAACCCAAGGCGTAACACCTGGGCAAAAGACTGATCCAGTTCGCGCCTTGGTAAAACTTGAGGCGAGCGCCTCGAGCATCGCTCAAGCAATGGCCGCTTGTATTCAAGTGCCTATCTCTCAGAACGAGTATGACGCTTATGTCTCGTTTAGCTACAACTTGGGACCCGGTACTTTTTGTAAGTACATCGCCCCCGTTCTAAACAAGCCTGACTACGAGGGCGCTTGCAAAAAGATCCTGCTATTCGATCACGCCGGTGGCAAGAAATACCCGGGGCTGACTAGGCGCCGGGAAGAGGAGTCACAAAAATGCCTTGGATTGGACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (53jIP) rather than this protein.
PDB ID
53jIP
Method AlphaFoldv2
Resolution 95.32
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50