Protein

Protein accession
A0A6J7W7Z6 [UniProt]
Representative
5GMvl
Source
UniProt (cluster: phalp2_2498)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MTITVTAWQPLAEGLIRQFEGCKLKAYLCPAGVPTLGWGATGPDIHLGMNWTQDQADARLLADLQCFGDQVAALVKAASTTAHQFAALTSFHYNTGELGHSTLLRMHLAGDYAGAKAEFQKWNKARVNGELVPLGGLTKRRAAEAALYGKADV
Physico‐chemical
properties
protein length:153 AA
molecular weight:16397,6 Da
isoelectric point:7,76
hydropathy:-0,05
Representative Protein Details
Accession
5GMvl
Protein name
5GMvl
Sequence length
229 AA
Molecular weight
24069,22380 Da
Isoelectric point
7,00111
Sequence
MKLNAAGIALIKEREACRLEAYLCPGGVWTIGYGHSGSEIHEGLAITPADAEALLHADLLRIDACVARLCPSATESQHAAMVCLAYNIGCGAFSRSSVARLHNAGRTAEAAQAFALWNKARGRVLPGLVARRAAEVALYLADDGTAAGFADGEKPLSESRTLAGSSLGGAAVGATALGELASQVDAWRSQTLALLPYFESLRWALLVLILAGLSLAAYARWHDRREGRS
Other Proteins in cluster: phalp2_2498
Total (incl. this protein): 297 Avg length: 206,8 Avg pI: 8,90
Protein ID Length (AA) pI
5GMvl 229 7,00111
12FlV 144 9,15827
1512k 221 9,86490
165QR 227 9,11597
174j2 172 5,96829
17IKU 183 8,94526
191vm 233 9,32169
1940B 183 7,93111
1BM2I 226 9,29842
1J499 180 9,59104
1JNAo 221 9,64578
1K6KV 225 9,07465
1KTSs 147 9,51110
1Kzwe 227 9,65635
1Mcsn 240 9,57679
1MnMv 233 8,65831
1aPGF 233 9,61412
1aT32 237 9,01753
1anqu 229 5,79140
1azzV 230 9,13216
1fu3d 240 9,38636
1lB93 229 9,04551
1lJlp 237 6,95012
1lKYe 239 9,22396
1lvp1 142 9,35676
1om1Y 178 9,89656
1yDOf 215 7,89101
1yg4Z 230 9,42639
1zIl6 255 7,83815
23l51 225 9,17155
24Prh 229 6,09998
24Q60 242 9,42587
25BB6 227 9,21313
2AWJ0 177 9,59594
2AWJj 177 9,73693
2B2dj 177 9,59594
2FVa7 225 9,54346
2Gq2I 225 9,27695
2Gs12 225 9,41782
2HDZ6 228 9,09534
2HIEx 225 9,15143
2I5K8 225 9,17168
2IpKA 233 9,06421
2IxKU 231 9,42491
2JmV9 203 8,52963
2KEDA 226 7,76616
2MLXq 231 8,97189
2RjIT 226 9,39222
2VEtx 141 9,85201
2YpeX 144 9,28314
2ar8k 182 7,67414
2bcpG 221 9,49215
2cLSw 246 9,29913
2crZ2 227 9,40576
2cs0w 228 9,85807
2ezyD 302 7,74263
2gb6V 233 9,61657
2nN41 145 9,31892
2rCsn 230 9,63475
2rPcH 230 9,73880
2rQXG 230 9,67588
2sj97 246 9,99681
30b2E 144 9,56906
34VgF 229 6,33416
35eE7 230 9,54869
35fNN 237 9,22312
38ieH 232 9,15163
38zwA 147 9,16877
3EhSq 146 4,98503
3SJ8A 225 9,44599
3T4k8 175 10,45563
3Xf7F 240 7,80327
3b7ff 144 9,23840
3bmjq 237 9,29900
3iFDe 227 9,12474
40oyC 197 9,69284
40w3K 221 9,54862
42SWU 181 8,85649
43Rkl 235 9,00393
44K00 241 9,29874
44Wqj 227 8,97137
44ldS 235 9,26038
45XjJ 233 9,06537
48VDh 185 6,56760
48rVO 233 9,23150
48tOa 233 9,37991
499BC 233 9,17155
4A4kw 226 8,92354
4AauS 226 6,63308
4Awrn 166 9,52019
4DfMI 234 9,73384
4FJ3L 232 9,09618
4FMQP 232 9,17187
4G938 200 9,09676
4GDVe 184 8,75856
4Gg36 184 8,78628
4ILmQ 233 9,17155
4KtL3 258 9,17329
4NEJQ 182 9,18502
4NaEL 184 7,86877
4NliW 184 8,48799
4NyNz 184 8,55072
4PsRn 226 9,13757
4Pvam 256 6,45307
4SHIq 225 9,42613
4UoAm 222 6,01859
4XS59 230 9,42097
4XWnZ 230 9,40105
4Xv4u 229 9,61773
4aZzz 230 9,29881
4anrp 234 9,46243
4f0GW 229 9,75666
4ggTX 232 9,02868
4h1I0 233 9,54830
4l8jj 232 8,73071
4lqbr 227 8,92328
4mZDr 257 9,74048
4nKAQ 182 8,54678
4o5fE 226 8,58798
4oaCg 226 7,76554
4s3JH 144 9,28314
4sZkT 256 8,86068
4wYLE 233 9,43941
51w1d 182 8,54801
52922 237 9,46107
54yjJ 305 6,61961
56FyX 184 8,76630
582zN 259 9,16993
599Oh 247 6,77097
5GBVm 240 6,22128
5dxQL 234 9,57376
5eKqf 183 9,07536
5g8Bx 184 8,75212
5gc70 183 7,85098
5i6GX 234 9,38803
5jQwm 233 8,95680
5msJc 221 9,57344
5ui0H 246 9,19192
5xlzp 245 6,91113
5y853 225 8,78918
6Ajsn 233 8,62589
6DlQW 236 9,60368
6Dxpv 229 9,59104
6HLBB 234 9,45843
6Ld45 216 5,62771
6MyNH 226 8,92354
6MyNV 256 9,03217
6PNYl 224 8,81304
6SdQD 278 9,22473
6SyWH 232 9,00148
6TYLt 244 7,92086
6TwGA 218 5,61338
6TyDP 283 8,38439
6VHHG 253 8,31992
6x0Np 267 9,93943
6x539 262 9,59588
6xIF5 184 8,74438
6xr1H 234 9,42323
6xrxJ 235 9,40312
6y0GK 233 9,32169
6yJa5 166 9,52019
71RkK 166 9,88779
71SmZ 170 9,32820
71SpU 166 9,57866
71St5 170 9,46720
71ZfB 165 9,81849
71ZjN 170 9,46720
71ZlJ 164 9,32820
71Zro 166 9,22596
71Zuu 168 9,71108
71Zwu 166 9,22596
71ZxF 166 8,99948
724Qq 166 9,54740
724hi 166 9,38713
724ls 166 9,54256
724sR 170 9,35199
728ZJ 166 9,88869
784Qb 164 9,71044
79fKg 232 9,14363
79g0V 203 4,92256
79wu9 237 9,41414
79xw4 164 9,73461
7AXYk 203 9,82435
7AY1P 203 10,05547
7BaKU 164 9,43271
7BkZ4 166 9,54740
7H582 147 5,21250
7Ry0a 170 9,73461
7SfVk 166 9,38745
7T1AO 181 9,56364
7UPnQ 229 6,16990
7X2vO 234 9,60787
7Yrzh 176 9,79592
7YsNL 176 9,64623
7bkDs 220 8,73123
7dPqs 170 9,95226
7dj6P 238 7,88205
7dy0s 237 9,51600
7kmk2 166 9,68800
7kmlc 164 9,78638
7kmoL 164 9,61812
7mx44 166 9,26760
7mx58 165 9,43355
7nXuG 176 8,74844
7on4D 293 9,47474
7pYDK 237 9,39312
7ptXF 230 9,31750
7qv8o 237 9,58402
7qv9I 237 9,78271
7rIgP 215 9,29752
7rK49 216 10,28801
7rZS3 237 9,39280
7rw7r 237 9,49311
7sC6s 165 9,81932
7sYUP 165 9,81849
7sf9I 237 9,70754
7tmJT 165 9,26831
7tmLp 166 9,94111
7tmM0 164 9,32820
7tmP5 164 9,70979
7tmRR 168 9,67060
7vMOd 166 9,54740
7vMPT 166 9,54256
7vMSV 166 9,38706
7vMV2 164 9,68865
7vMVY 166 9,54740
7vMXZ 164 9,93150
7vMZE 166 9,81849
7vVFa 218 9,82622
7wAiD 166 9,71044
7wAoy 166 9,54740
7wApv 164 9,22557
7wAuZ 164 9,58775
7wOAo 156 8,99974
7wOuj 166 9,81849
7wOye 166 9,54740
7wOyy 164 9,93150
7z5BG 222 9,86336
7z5Xf 237 9,62676
7zfor 226 9,83660
80YX9 226 9,78477
80Z4D 182 9,35799
81i1a 172 10,03903
83AKf 234 6,97928
86A6f 147 5,39376
89HvO 259 9,07736
8B1ts 237 8,79763
8B4iK 184 8,44679
8BQnE 179 9,34877
8EDNr 150 5,24666
8ERWC 228 9,71128
8G5Gv 147 5,62782
8HimO 170 9,73461
8alBY 174 9,46127
8eHL4 246 9,07117
8h7IG 147 5,62782
8iGXB 259 8,66534
8jhac 259 7,66289
8jnQt 246 9,24562
8lsrF 226 7,88289
8nylg 230 9,29881
8tqLY 233 9,32917
8v2LN 181 9,51407
8v7aI 187 9,99094
8ykJ0 150 5,08154
8z2uO 147 5,62782
8zO7R 177 6,62779
97I9 266 9,69503
ANnB 226 7,76616
C87 233 8,57889
LQgF 247 8,44795
ROiv 144 8,62208
RPCO 233 9,17155
T4Q0 233 9,17155
Tcb1 185 7,11820
UaiE 184 6,91415
Ycsn 246 9,11230
btsB 263 9,49769
dhTw 143 6,90306
dmz 166 9,88779
dvK 166 9,54740
enxq 144 9,20597
fqH4 222 9,63739
gABW 229 9,70915
gAHN 235 9,56487
jtt1 226 8,76739
lYoL 226 6,75608
lmJE 231 6,37980
pXKt 233 8,54536
sySF 154 9,29816
sz3e 153 6,57237
xkEL 166 7,71108
yH6L 228 9,00825
zPEx 183 10,11930
zTRL 182 9,95529
A0A6J5RYU1 205 6,74266
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26378
1q5mp
 207 44,5% 240 7.059E-74
2 phalp2_33221
5jbqV
 447 53,4% 144 3.458E-70
3 phalp2_28113
7zmZV
 50 51,0% 149 1.868E-67
4 phalp2_29738
1pBjt
 830 36,0% 247 3.505E-67
5 phalp2_2632
6RhYr
 14867 52,8% 142 3.923E-65
6 phalp2_40579
4SZ2W
 11 36,8% 217 1.908E-61
7 phalp2_10966
4MkR6
 70 43,5% 202 1.258E-60
8 phalp2_6830
8n5Jv
 121 48,3% 149 8.295E-60
9 phalp2_2176
3Yhf4
 930 46,7% 154 5.467E-59
10 phalp2_126
5jCCA
 637 45,4% 143 7.486E-59

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 5GMvl (229 AA)
Member sequence: A0A6J7W7Z6 (153 AA)
1 229 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798200 [NCBI]
CDS location
range 1616 -> 2077
strand -
CDS
ATGACAATCACCGTCACTGCCTGGCAGCCGCTGGCCGAGGGGCTGATCCGACAGTTCGAGGGCTGCAAGCTGAAAGCCTATCTCTGTCCTGCGGGCGTACCGACGCTGGGCTGGGGCGCGACCGGGCCGGATATTCACCTCGGCATGAACTGGACGCAGGACCAGGCCGACGCGCGGCTGCTGGCCGATCTGCAATGCTTCGGCGATCAGGTGGCGGCGCTGGTCAAGGCAGCTTCGACCACTGCCCACCAGTTCGCGGCGCTGACCTCGTTTCACTACAACACGGGCGAGCTTGGTCATTCCACGCTGCTCCGGATGCACCTCGCAGGTGATTACGCCGGCGCCAAGGCGGAGTTCCAGAAATGGAACAAGGCGCGTGTGAACGGCGAACTGGTTCCGCTCGGGGGCCTGACGAAGCGCCGGGCGGCAGAGGCTGCGCTTTATGGGAAGGCGGACGTATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5GMvl) rather than this protein.
PDB ID
5GMvl
Method AlphaFoldv2
Resolution 79.78
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50