Protein

Protein accession
A0A6J5SGB2 [UniProt]
Representative
2UiYx
Source
UniProt (cluster: phalp2_31389)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNLPEASKPLARRFEGLRLKSYLCPAGVWTVGYGATGPDIGPGKVVTPEWAEDRLERDLMAFIPQVLKACPVLLTEPPDRLASILDFTFNLGGARLRASTLRTRVNARDWAGADHELRKWVRGGGRVLPGLVLRRAADAALL
Physico‐chemical
properties
protein length:142 AA
molecular weight:15556,9 Da
isoelectric point:9,90
hydropathy:-0,09
Representative Protein Details
Accession
2UiYx
Protein name
2UiYx
Sequence length
255 AA
Molecular weight
27438,34710 Da
Isoelectric point
9,73307
Sequence
VVTGIGGGAIAVQYFWLQQWVDSVTGLVALGGLIFGCGLPGLAIVRWVFGGGSDHQLWRTVTRTLNNAGQLCGGPSGVVGRGVELLVPGGCVRPGAAVIAVPQAAIDLAKRFEGFHRVPRADPGRAHPYICPAGYWTIGYGHLCDPKHLPITEAEAEGHLAADLRTALNATLRYCPVLATEPEGRLAAIVDFTFNLGAGRLQTSTLRRRVNQREWVAAATELRRWVYGRGRVLAGLIGRRDAEAIWLLRNPPQRL
Other Proteins in cluster: phalp2_31389
Total (incl. this protein): 4 Avg length: 181,3 Avg pI: 9,57
Protein ID Length (AA) pI
2UiYx 255 9,73307
K4I410 179 9,32756
A0A6J5KUH0 149 9,33691
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6830
8n5Jv
 121 35,5% 180 2.611E-24
2 phalp2_1869
3V0OR
 7 36,1% 166 1.917E-22
3 phalp2_29484
1KOZ4
 4 32,0% 162 6.107E-18
4 phalp2_10624
2nrBp
 12 34,5% 165 1.120E-17
5 phalp2_34395
4g6xF
 2 30,8% 162 5.694E-13
6 phalp2_23797
1duFR
 19 30,3% 165 9.441E-10

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 2UiYx (255 AA)
Member sequence: A0A6J5SGB2 (142 AA)
1 255 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR797276 [NCBI]
CDS location
range 9935 -> 10363
strand +
CDS
ATGAACCTGCCCGAAGCATCGAAGCCCCTCGCGCGCAGGTTCGAGGGGCTTCGGCTTAAATCCTACCTGTGCCCGGCCGGGGTCTGGACGGTCGGATACGGGGCTACAGGCCCCGACATCGGCCCGGGTAAGGTCGTGACACCGGAGTGGGCCGAAGATCGCTTGGAGCGCGATCTGATGGCCTTTATCCCCCAGGTCCTGAAGGCATGCCCGGTGTTGCTGACCGAACCCCCGGATCGACTGGCCTCGATCCTCGACTTCACCTTCAACCTGGGCGGCGCCCGCTTAAGGGCTTCCACCCTACGGACGCGGGTAAACGCCCGAGATTGGGCGGGCGCGGATCACGAGTTACGCAAATGGGTCCGAGGAGGTGGGCGGGTGTTACCGGGGCTGGTCTTGCGACGAGCGGCGGACGCCGCGCTGCTTTAG
CDS Source ID
[NCBI]
CDS Source
LR797388 [NCBI]
CDS location
range 20369 -> 20797
strand -
CDS
ATGAACCTGCCCGAAGCATCGAAGCCCCTCGCGCGCAGGTTCGAGGGGCTTCGGCTTAAATCCTACCTGTGCCCGGCCGGGGTCTGGACGGTCGGATACGGGGCTACAGGCCCCGACATCGGCCCGGGTAAGGTCGTGACACCGGAGTGGGCCGAAGATCGCTTGGAGCGCGATCTGATGGCCTTTATCCCCCAGGTCCTGAAGGCATGCCCGGTGTTGCTGACCGAACCCCCGGATCGACTGGCCTCGATCCTCGACTTCACCTTCAACCTGGGCGGCGCCCGCTTAAGGGCTTCCACCCTACGGACGCGGGTAAACGCCCGAGATTGGGCGGGCGCGGATCACGAGTTACGCAAATGGGTCCGAGGAGGTGGGCGGGTGTTACCGGGGCTGGTCTTGCGACGAGCGGCGGACGCCGCGCTGCTTTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2UiYx) rather than this protein.
PDB ID
2UiYx
Method AlphaFoldv2
Resolution 78.60
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50