Protein

Protein accession
A0A6J5RZ71 [UniProt]
Representative
4r87F
Source
UniProt (cluster: phalp2_26909)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSRVSRALWKRRLTYRQKRVSHWRAKGNIVKVNYWLSLVREAKHKLAPVKPLHGIDVFEGDGKIDWIRARSKGVEFVFLKCSEGGDFRDKAWTAKRVKEIRASGIPFGPYHFLRPRAGRRGEVEARFFIETARKAGWGKGDLRPVIDFEVSDLPPSQTIRYLEQAVKEVKRLTGKPPIIYTGGPFWDENGGGRNNWGCPLWLAAYVAKPNDFVPRAWKTWTIWQYTDKGGVAGVEAANVDQNLAHNLPKL
Physico‐chemical
properties
protein length:250 AA
molecular weight:28608,6 Da
isoelectric point:10,20
hydropathy:-0,54
Representative Protein Details
Accession
4r87F
Protein name
4r87F
Sequence length
229 AA
Molecular weight
26463,53460 Da
Isoelectric point
9,50266
Sequence
MRAGRGRIYGVDVYEGDGDIDWRAVSAAGNSFAIVKVSEGDYMDSRSTPERIAAIRASGMTAGAYVFLRPKSGRSGRVEARTLVERGMDIGLWRRDRQTVRDIRPVLDCEASGYDLGTVAGRRATRVYIRDAVREVVRLTGHRPMIYTGKWWWEQTQEDRLRWTWHDWQCPLWLAAYVSDPAPYLPRGWQRAAMWQYTDRARVDGISQPCDRNVYLGADWHHFTRQLTY
Other Proteins in cluster: phalp2_26909
Total (incl. this protein): 36 Avg length: 257,6 Avg pI: 6,52
Protein ID Length (AA) pI
4r87F 229 9,50266
19Mdw 254 10,13458
1IT4N 264 5,00742
1MH6W 264 5,01754
1XuC9 262 6,65729
1fvxZ 285 7,11791
2KaR 256 5,66153
3TZrr 303 5,51829
4CXue 237 5,42008
4Eavp 307 4,21054
4EjIK 291 6,04383
4UFoE 227 5,95607
4UNMi 261 4,96195
4bT0d 252 5,47942
4bzkW 230 7,05334
4ckHC 239 9,05550
4eIZs 219 4,95905
4eU4M 258 6,00609
4eY4s 253 5,19175
4etbS 257 4,95104
4g3ic 256 5,39660
4gQaW 282 4,87112
4gRe7 280 4,62359
4v9Eu 251 4,80877
4wgl9 239 5,07353
4zfQ4 301 9,88463
5H2mL 276 8,09621
5H9hi 253 5,00930
5aD0y 254 10,05683
5vLsP 229 6,21252
6Nt9C 241 4,52424
6xFp2 256 10,12529
8ohMq 250 10,29839
8swQg 247 5,20335
l2QZ 260 6,44306
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39912
1jXPT
 300 33,9% 215 4.016E-53
2 phalp2_10644
2AeOK
 60 33,0% 209 1.410E-52
3 phalp2_32129
6Dieh
 5 30,8% 217 2.099E-44
4 phalp2_35314
79Mal
 26 30,9% 220 4.813E-43
5 phalp2_26738
367Qc
 15 29,0% 224 4.309E-42
6 phalp2_36157
6TiaL
 25 28,9% 214 2.520E-40
7 phalp2_5862
5yfd0
 6 30,2% 218 7.864E-39
8 phalp2_5615
4g2xP
 40 27,3% 216 5.132E-38
9 phalp2_20360
2RVWF
 69 28,7% 212 3.347E-37
10 phalp2_34559
4UNXW
 287 27,9% 218 2.181E-36

Domains

Domains [InterPro]
GH25
Representative sequence (used for alignment): 4r87F (229 AA)
Member sequence: A0A6J5RZ71 (250 AA)
1 229 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR797260 [NCBI]
CDS location
range 18465 -> 19217
strand +
CDS
ATGAGTCGCGTTTCGCGGGCGCTCTGGAAGCGCCGCCTCACGTACCGTCAGAAGCGCGTCAGCCACTGGAGGGCCAAGGGGAACATCGTCAAGGTGAACTACTGGCTGTCGTTGGTGCGCGAAGCGAAGCACAAGCTTGCTCCGGTCAAGCCGCTCCACGGTATTGACGTATTTGAGGGCGACGGCAAGATCGACTGGATCCGGGCGCGCAGCAAGGGTGTTGAGTTTGTATTCCTGAAGTGCTCGGAAGGTGGAGACTTTCGTGACAAGGCTTGGACGGCCAAGCGTGTCAAGGAGATCAGAGCTTCTGGGATCCCGTTCGGTCCGTACCACTTCCTGCGACCTCGCGCTGGTCGTCGTGGTGAAGTTGAAGCACGGTTCTTCATCGAGACTGCGCGCAAGGCTGGTTGGGGCAAGGGCGACCTACGGCCAGTAATCGACTTTGAGGTTTCAGACCTCCCGCCGTCGCAAACGATTCGGTACTTGGAGCAAGCGGTCAAAGAGGTCAAGCGGCTTACCGGCAAGCCTCCGATCATCTACACGGGCGGGCCATTCTGGGACGAGAACGGCGGAGGGCGCAATAACTGGGGTTGTCCTCTATGGCTCGCAGCCTACGTTGCGAAGCCAAACGATTTCGTGCCTCGCGCTTGGAAGACTTGGACGATCTGGCAGTACACGGATAAGGGTGGGGTTGCCGGAGTTGAAGCAGCGAACGTTGATCAGAATCTTGCCCACAATCTCCCGAAGCTCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4r87F) rather than this protein.
PDB ID
4r87F
Method AlphaFoldv2
Resolution 89.77
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50