Protein

Protein accession
A0A6J5QDD3 [UniProt]
Representative
2oONW
Source
UniProt (cluster: phalp2_24175)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MNLDIAAALCKRFEGFKAKPYLCPAGVPTIGYGSTYYANGRKVTLTDETISETIAETLLLHELHHTYLPGVLRHCPILLTYERKCNAIVDFAYNLGIGRLQTSTLKRKINDQDWDAAQEQLMLWTKGGGKVLPGLVKRRSAEVSLLAA
Physico‐chemical
properties
protein length:148 AA
molecular weight:16421,9 Da
isoelectric point:8,90
hydropathy:-0,09
Representative Protein Details
Accession
2oONW
Protein name
2oONW
Sequence length
213 AA
Molecular weight
23099,81160 Da
Isoelectric point
8,97189
Sequence
MTSPGLEICEDSEGYAKEIPGGDCVAYWDAMGSVWTIGFGTTGPDVKKGVRWPRATAEERLTLGWHKARAGVLRASPILVRFPNRLEALTDWAYNLGVGRYQSSTLRQYVNQQRWADAAQEILKWNLAGGKVRSGLVKRRALERGLFLSQDTAIRSASPDSGTATVVPSSGQIESSATSSPVTEADSLAPVPIPTSEPQTLATRLAAFFRSLF
Other Proteins in cluster: phalp2_24175
Total (incl. this protein): 2 Avg length: 180,5 Avg pI: 8,93
Protein ID Length (AA) pI
2oONW 213 8,97189
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26708
2SbXz
 558 46,3% 149 9.987E-38
2 phalp2_2498
5GMvl
 297 44,2% 149 1.812E-26
3 phalp2_33221
5jbqV
 447 45,9% 135 6.288E-26
4 phalp2_28113
7zmZV
 50 40,5% 148 3.574E-24
5 phalp2_2632
6RhYr
 14867 44,6% 132 1.237E-23
6 phalp2_2176
3Yhf4
 930 39,7% 151 1.237E-23
7 phalp2_11002
4Mz75
 307 40,2% 139 1.085E-22
8 phalp2_8851
2IyxA
 73 40,5% 148 6.965E-22
9 phalp2_6830
8n5Jv
 121 39,7% 141 9.813E-20
10 phalp2_3619
4ONI2
 18 33,8% 201 2.477E-19

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 2oONW (213 AA)
Member sequence: A0A6J5QDD3 (148 AA)
1 213 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796893 [NCBI]
CDS location
range 5166 -> 5612
strand -
CDS
ATGAATCTAGACATTGCAGCGGCGCTGTGCAAGCGGTTTGAGGGCTTTAAGGCCAAGCCTTACCTTTGCCCAGCCGGTGTCCCAACGATTGGATATGGCAGCACTTATTACGCCAACGGGCGTAAGGTGACGTTGACAGATGAAACGATCTCTGAAACGATTGCTGAAACATTGTTGTTGCATGAATTGCACCACACCTACCTACCTGGCGTCTTGCGGCACTGCCCAATTTTATTGACTTATGAGCGCAAGTGCAACGCCATTGTGGATTTTGCCTACAATTTGGGCATAGGCCGTTTGCAGACCAGTACCCTCAAGCGAAAGATCAATGACCAGGATTGGGACGCCGCCCAAGAACAGTTGATGCTGTGGACTAAGGGCGGCGGGAAGGTGCTGCCAGGACTTGTTAAGCGCCGGTCTGCTGAAGTTTCCTTATTAGCTGCATAG
CDS Source ID
[NCBI]
CDS Source
LR796976 [NCBI]
CDS location
range 20306 -> 20752
strand -
CDS
ATGAATCTAGACATTGCAGCGGCGCTGTGCAAGCGGTTTGAGGGCTTTAAGGCCAAGCCTTACCTTTGCCCAGCCGGTGTCCCAACGATTGGATATGGCAGCACTTATTACGCCAACGGGCGTAAGGTGACGTTGACAGATGAAACGATCTCTGAAACGATTGCTGAAACATTGTTGTTGCATGAATTGCACCACACCTACCTACCTGGCGTCTTGCGGCACTGCCCAATTTTATTGACTTATGAGCGCAAGTGCAACGCCATTGTGGATTTTGCCTACAATTTGGGCATAGGCCGTTTGCAGACCAGTACCCTCAAGCGAAAGATCAATGACCAGGATTGGGACGCCGCCCAAGAACAGTTGATGCTGTGGACTAAGGGCGGCGGGAAGGTGCTGCCAGGACTTGTTAAGCGCCGGTCTGCTGAAGTTTCCTTATTAGCTGCATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2oONW) rather than this protein.
PDB ID
2oONW
Method AlphaFoldv2
Resolution 82.51
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50