Protein

Protein accession
A0A6J5PCE3 [UniProt]
Representative
8t1Gv
Source
UniProt (cluster: phalp2_37325)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MADALDLAFEIATRPNFDCLHDPNPRTALIEPYHDPVGYPTQGYGRLLSRVEWEDLSKYPAITVEQAKADLVVDLKTAQRGTHRLIKADLQPHQWAALYDFTFNAGAGNLQISAFRAQINRGELADVPQQLLRWVYANHVKWPGLVRRRAAEGRMWTEGR
Physico‐chemical
properties
protein length:160 AA
molecular weight:18207,4 Da
isoelectric point:6,97
hydropathy:-0,45
Representative Protein Details
Accession
8t1Gv
Protein name
8t1Gv
Sequence length
166 AA
Molecular weight
18748,19620 Da
Isoelectric point
9,09547
Sequence
MDEILKLASEVAKPFEGLFLKPYYDPVGYPTQGYGRLLSRQVWGPLGRSPQNKAEKKVAEEWLYERYPTIDEHTAELWLQQDMITATRAAIRLCPGASKPTQLAALADFAFNCGSGNLELSTLRRKVNQGDIESAANEFGRWVYARGVKLPGLVRRRNSEKQLFLS
Other Proteins in cluster: phalp2_37325
Total (incl. this protein): 89 Avg length: 152,8 Avg pI: 8,26
Protein ID Length (AA) pI
8t1Gv 166 9,09547
15JQY 177 9,72314
15O7Y 156 9,20004
171da 175 9,48035
1HKG6 162 7,09637
1JUys 150 8,16017
1K3TS 156 9,69413
1KA7B 138 9,18599
1ifYB 147 8,98427
1lKD1 156 9,24227
1pBEU 177 8,81272
1pYa7 159 7,91119
1pz9x 150 8,91664
1q1CY 149 8,71795
1ql0f 149 8,70344
1tLbo 146 9,06537
1uPNU 146 9,03803
2B9qT 144 5,01032
2Cbbb 151 8,64310
3431D 149 8,67649
35e92 155 5,03880
37VW3 159 8,50565
3VRDi 150 8,95203
3Y8Qj 148 9,36398
3zVjN 143 5,90508
43wJ1 147 8,59185
4DIQ3 146 9,02868
4DTO7 148 6,14926
4Drt6 165 10,41598
4Eip8 143 5,14463
4H894 147 6,28687
4HAfV 143 5,33232
4MqZn 156 9,24459
4NLeL 149 8,86571
4TDUK 143 6,74016
4a2s8 150 9,11958
4f6BE 141 6,14909
4f8eS 176 8,97324
4fqgZ 175 8,88434
4jon3 148 8,94855
4nrVZ 148 8,77913
4piJw 149 8,66386
4qNZ2 132 9,06865
4qic6 149 8,66386
4vXup 153 7,56899
4wa59 150 6,25652
56eLc 149 8,32050
5Gos 148 6,74425
5drHy 147 8,38535
5eV9X 147 8,82561
5vmol 150 8,67359
6DQY0 146 9,39519
6Dykn 146 9,25645
6EZPO 146 9,06672
6IJzf 148 9,07891
6J6Vg 146 9,43148
6LPCY 132 9,45824
6Lg9N 143 6,17132
6M3oD 154 9,31976
6Mh1h 132 9,26393
6RB3Y 153 7,13349
6Rldv 165 6,89874
6RnhV 166 6,32819
6SfL3 165 9,35573
7XfEy 150 7,75110
7dggU 159 8,68462
7eaAC 151 8,00628
7gCHi 161 8,68352
7lEQE 158 8,84850
7shjZ 157 6,83184
7xEqR 151 8,06907
86QNt 155 6,43397
88QWb 166 9,09547
8BwXv 161 5,18550
8aj9W 149 8,59694
8dqOD 159 6,89999
8fLMp 158 6,91500
8lGox 138 11,10489
8mz8q 147 7,72814
8n1Dn 185 10,84663
8obBF 150 8,63755
8sNLq 150 8,32991
GhoZ 149 8,67649
ZYHl 142 9,09599
dPxz 180 9,96593
dQrY 149 9,46256
syk 157 6,07964
A0A5Q2WDR4 156 9,16188
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4451
31DIk
 4919 36,9% 165 3.792E-57
2 phalp2_28113
7zmZV
 50 37,1% 164 3.137E-55
3 phalp2_2632
6RhYr
 14867 38,7% 165 1.007E-53
4 phalp2_34911
4lF8s
 21 37,9% 158 6.678E-53
5 phalp2_6830
8n5Jv
 121 37,1% 167 4.429E-52
6 phalp2_40213
2kZ5j
 4390 40,3% 161 2.937E-51
7 phalp2_33221
5jbqV
 447 36,9% 165 5.518E-51
8 phalp2_32792
2snIK
 45 34,5% 162 2.426E-49
9 phalp2_2498
5GMvl
 297 34,7% 164 3.325E-49
10 phalp2_18221
4OkMH
 137 36,3% 176 4.141E-48

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 8t1Gv (166 AA)
Member sequence: A0A6J5PCE3 (160 AA)
1 166 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796773 [NCBI]
CDS location
range 9481 -> 9963
strand -
CDS
GTGGCTGACGCGCTCGATCTAGCCTTCGAGATTGCCACCCGACCGAACTTCGACTGCCTCCACGACCCCAACCCACGCACAGCACTGATCGAGCCCTACCACGACCCAGTCGGTTATCCGACGCAGGGCTACGGTCGGCTGCTGTCGCGGGTGGAGTGGGAAGACCTGTCGAAGTATCCGGCCATCACGGTGGAGCAAGCGAAGGCTGACCTCGTTGTCGACCTCAAGACGGCACAGCGAGGCACTCACCGCCTGATCAAGGCAGACCTCCAACCCCATCAGTGGGCTGCTCTCTATGACTTCACGTTCAACGCGGGCGCGGGCAACCTGCAGATCAGTGCCTTCCGCGCACAGATCAATCGCGGCGAACTCGCCGATGTGCCGCAACAGCTGCTCCGCTGGGTCTACGCTAATCACGTCAAGTGGCCCGGCCTCGTGCGTCGTCGCGCCGCCGAAGGGCGCATGTGGACGGAGGGGCGATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8t1Gv) rather than this protein.
PDB ID
8t1Gv
Method AlphaFoldv2
Resolution 97.80
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50