Protein

Protein accession
A0A6J5NQY6 [UniProt]
Representative
hSPR
Source
UniProt (cluster: phalp2_1223)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 74% (predicted by ML model)
Protein sequence
MIRLKSLLVEAKITGTELSNNDSFISYLKKVEGFKDKAYDDQDPTKVINPGDDVKGVLTIGYGHTGADVKPGDTITEQQATIKLKQDIIEHFNRAYEYVSQKFPNQLSKLNLDQWMMLTDFAFNPGLSEFPKFAEAVVYKNWTNAVKQYKRFFNGKELTGRNSQFYTMFLVDKDTSYKELGKGTNAPNNITGANGNPLTSKEYCSMLNGAPQFTAWIGRIMRFAEYYVEANQKKNGVTLPLNSYIKKYYPELTNIGITPENWDKPTFCSKG
Physico‐chemical
properties
protein length:271 AA
molecular weight:30768,5 Da
isoelectric point:8,75
hydropathy:-0,58
Representative Protein Details
Accession
hSPR
Protein name
hSPR
Sequence length
271 AA
Molecular weight
30407,24850 Da
Isoelectric point
9,09702
Sequence
MIRLKSLLTEVKITGNDVSNDQSFVSYLKKVEGFKDKAYDDQDPTKVINPGDVVKGVLTIGYGHTGPDVKPGDTITEPAATSKLKQDIIEHFDRAYAYVSGKFPNEIANLDLEQWKMLTDFAFNPGLNKFPKFAEAVVFKNWPSAIKNYKRFFNGSELTQRNSQFYSLFLVDKDTSYKELGKGKDAPANLVGTTGKTLTSVDYCSKLAGAPQFTAQIARIMRFAEYYVEANKKKNGVTLPLNTYIKKYYPELTNIGITPQNWDKPAFCSRG
Other Proteins in cluster: phalp2_1223
Total (incl. this protein): 2 Avg length: 271,0 Avg pI: 8,92
Protein ID Length (AA) pI
hSPR 271 9,09702
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_21123
AWqg
 1 38,8% 193 2.951E-26
2 phalp2_19108
1tXQQ
 91 30,9% 184 5.161E-07
3 phalp2_38422
17tKX
 93 27,6% 195 3.842E-05

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): hSPR (271 AA)
Member sequence: A0A6J5NQY6 (271 AA)
1 271 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796697 [NCBI]
CDS location
range 35424 -> 36239
strand +
CDS
ATGATACGTTTAAAATCTTTACTAGTAGAAGCCAAAATCACCGGTACTGAATTATCAAACAATGATTCATTTATCAGTTATTTAAAAAAAGTAGAAGGCTTTAAAGATAAAGCATATGATGATCAAGATCCTACTAAAGTAATAAACCCGGGAGATGATGTTAAAGGAGTATTAACTATAGGCTATGGTCATACCGGGGCTGATGTTAAACCTGGCGATACTATTACAGAACAACAAGCAACTATTAAATTGAAACAAGATATTATTGAACATTTTAATAGAGCATATGAATATGTTTCTCAAAAATTTCCAAATCAACTATCAAAGTTGAATTTAGATCAATGGATGATGCTAACAGATTTTGCATTTAATCCTGGACTTAGTGAATTTCCGAAATTTGCAGAAGCTGTTGTATATAAAAATTGGACTAATGCAGTTAAACAATATAAAAGATTTTTTAATGGTAAAGAATTAACCGGACGAAATTCTCAATTCTATACAATGTTTTTAGTTGATAAAGATACATCATATAAAGAATTGGGTAAAGGTACAAATGCACCTAATAACATTACCGGGGCAAATGGAAACCCACTAACATCTAAAGAGTATTGTTCCATGTTAAATGGTGCACCACAGTTTACAGCATGGATTGGAAGAATTATGAGATTTGCTGAATATTATGTTGAGGCAAATCAAAAGAAAAATGGTGTGACATTGCCATTAAATTCATATATTAAAAAATATTATCCGGAATTAACAAATATTGGTATAACTCCGGAAAATTGGGATAAACCCACATTTTGTTCTAAAGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (hSPR) rather than this protein.
PDB ID
hSPR
Method AlphaFoldv2
Resolution 89.79
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50