Protein

Protein accession
A0A6J5NCQ4 [UniProt]
Representative
11yhI
Source
UniProt (cluster: phalp2_29354)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MDVTPAIDLCRRFEGFRPRPYLCPAGVPTIGYGTTRYLDGKPVTLDDAPITETAARVMLIDDLRTHFGPAVLRLCPGLIAFPARFNAILDFTYNLGAGRLQTSTLRRCVNAQDWDGAVEQLNKWVRGGGRVLPGLVARRAAESQLLR
Physico‐chemical
properties
protein length:147 AA
molecular weight:16212,6 Da
isoelectric point:9,38
hydropathy:-0,06
Representative Protein Details
Accession
11yhI
Protein name
11yhI
Sequence length
139 AA
Molecular weight
14901,56630 Da
Isoelectric point
8,12819
Sequence
VSLGQTITKEEAEQLLLTDLTAAALDTVRLCPVLAHSPIRWAAVADFTFNLGSGRLKASTLRRRINAGEYDDVPYELSRWVRGDGRVLPGLVARRNAEISLWKSADEHSAFTTGNLSGITGTTLSSAQFTGLANGSSGR
Other Proteins in cluster: phalp2_29354
Total (incl. this protein): 7 Avg length: 150,0 Avg pI: 9,03
Protein ID Length (AA) pI
11yhI 139 8,12819
1XLVD 145 7,82171
A0A6J5KR54 146 9,32330
A0A6J5NUL5 150 10,24262
A0A6J5PE26 162 9,16871
A0A6J5QDZ7 161 9,16871
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37101
1bvx6
 877 46,6% 103 1.169E-27
2 phalp2_19285
8enOZ
 460 39,7% 93 3.089E-24
3 phalp2_2632
6RhYr
 14867 43,1% 102 7.950E-24
4 phalp2_4451
31DIk
 4919 42,4% 99 9.880E-23
5 phalp2_126
5jCCA
 637 44,7% 105 1.681E-21
6 phalp2_9410
8Hj1q
 5109 44,5% 101 2.303E-21
7 phalp2_11002
4Mz75
 307 38,6% 101 4.322E-21
8 phalp2_33221
5jbqV
 447 40,7% 103 3.912E-20
9 phalp2_4305
8aoFg
 2477 39,2% 102 4.378E-18
10 phalp2_39267
4724r
 247 34,5% 107 6.673E-16

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 11yhI (139 AA)
Member sequence: A0A6J5NCQ4 (147 AA)
1 139 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796613 [NCBI]
CDS location
range 36501 -> 36944
strand +
CDS
GTGGATGTGACCCCAGCAATCGACTTGTGCAGACGGTTCGAGGGCTTTCGGCCACGCCCGTACCTGTGTCCGGCGGGTGTGCCTACGATTGGGTACGGCACGACGCGCTACCTTGACGGCAAACCAGTAACCCTGGATGACGCGCCAATCACCGAAACCGCGGCGCGCGTCATGCTGATTGATGACCTGCGCACGCATTTCGGCCCCGCAGTGCTGCGCTTGTGCCCCGGCTTGATCGCCTTCCCGGCACGCTTCAACGCCATTCTCGACTTCACCTACAACCTCGGGGCCGGCCGCTTGCAGACCTCGACGTTGCGCCGCTGCGTCAATGCGCAGGACTGGGATGGAGCGGTCGAACAGCTCAACAAGTGGGTGCGCGGCGGTGGCCGTGTGCTCCCTGGCCTCGTCGCACGACGCGCCGCAGAATCTCAACTGCTCCGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (11yhI) rather than this protein.
PDB ID
11yhI
Method AlphaFoldv2
Resolution 87.17
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50