Protein

Protein accession
A0A6J5MI31 [UniProt]
Representative
4870A
Source
UniProt (cluster: phalp2_25616)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MIKESLLAFIIGLEGFSSCAYLDVSQYSNGFGTKAANRWECISKTEAKSRMVKHLQEDSKHVLSLHPHATQNEHDALVSFCYNAGREGCAKTVKLVAQGKKDAAAWVMKNKINKGTKAEAGHRKRRTLEIALLNKKEEKKNFTCIYQEYS
Physico‐chemical
properties
protein length:150 AA
molecular weight:16867,2 Da
isoelectric point:9,36
hydropathy:-0,54
Representative Protein Details
Accession
4870A
Protein name
4870A
Sequence length
160 AA
Molecular weight
17852,22190 Da
Isoelectric point
8,58366
Sequence
MLSYAAMSKLIALLITLEGFSACAYWDVSQYSIGYGTRANSKYECIDKNAGKSRLINHLQGDIKFIKSVFSAKNSKPEETEIIGLASYCYNMGHNGCKKAVQLAANDEHRAASWVMRKEIKKGSGYEEGLTIRRAKETALLLEAAEKPSFTEWIISGYDY
Other Proteins in cluster: phalp2_25616
Total (incl. this protein): 6 Avg length: 152,7 Avg pI: 8,43
Protein ID Length (AA) pI
4870A 160 8,58366
17ZZp 160 8,27034
5nd0Q 158 8,97408
5y6Uh 129 6,46341
8vMeS 159 8,92521
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_14647
5H6Y6
 20 47,0% 134 2.464E-42
2 phalp2_23797
1duFR
 19 30,8% 136 1.881E-15
3 phalp2_9007
4WhBz
 18 29,6% 135 6.549E-15
4 phalp2_4415
2EHur
 207 29,9% 147 1.221E-14
5 phalp2_5874
5BWv1
 1 34,3% 131 1.221E-14
6 phalp2_18164
4uApd
 5 30,0% 143 3.109E-14
7 phalp2_12817
8iWIN
 6 27,7% 137 4.245E-14
8 phalp2_16325
5kZ2q
 25 30,6% 137 7.912E-14
9 phalp2_31073
1Mrll
 7 31,5% 133 3.297E-12
10 phalp2_35423
8yB6R
 1 29,2% 140 2.890E-11

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4870A (160 AA)
Member sequence: A0A6J5MI31 (150 AA)
1 160 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796435 [NCBI]
CDS location
range 39189 -> 39641
strand +
CDS
ATGATTAAAGAATCACTACTAGCCTTCATCATAGGCTTAGAGGGCTTTTCTTCTTGTGCGTACTTAGATGTAAGTCAATATTCTAACGGTTTTGGGACTAAAGCCGCTAATAGGTGGGAGTGTATAAGCAAGACCGAGGCTAAATCTCGCATGGTTAAGCACCTGCAAGAGGATAGCAAGCACGTACTATCATTACACCCTCACGCTACTCAGAATGAACATGACGCTCTTGTCAGTTTTTGCTACAACGCAGGGAGAGAAGGATGTGCAAAAACAGTTAAATTAGTAGCTCAAGGGAAGAAAGATGCTGCAGCTTGGGTGATGAAGAATAAAATAAATAAAGGCACTAAAGCCGAGGCAGGACACCGAAAAAGAAGAACTTTAGAGATAGCTTTATTAAACAAAAAAGAAGAGAAAAAGAATTTTACTTGTATATATCAGGAGTATAGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4870A) rather than this protein.
PDB ID
4870A
Method AlphaFoldv2
Resolution 92.71
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50