Protein

Protein accession
A0A6J5LRB2 [UniProt]
Representative
5hjd8
Source
UniProt (cluster: phalp2_37963)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MMTFSNKGLAFLKKAEHCVLTAYKDPLSKTGLPITIGYGSTMNTNGTRIKLGDRITQAQAEELLAWEVSKKSMILNFCELKVTQAQFDAIVLLTYNIGVGAFKDSTLRKMIKKNPEDPAIEAEWLKWHFAGGIPSRGLMNRRKGEYKIYSKSEYS
Physico‐chemical
properties
protein length:155 AA
molecular weight:17444,1 Da
isoelectric point:9,49
hydropathy:-0,31
Representative Protein Details
Accession
5hjd8
Protein name
5hjd8
Sequence length
389 AA
Molecular weight
41318,73340 Da
Isoelectric point
5,81431
Sequence
MRLSERGLELLREFEGFRDRAYPDPGSRDGLPVTIGYGSTRYEDGSPIKLGDTITRERADEMLRREVAETEGAVDRLVTVPLAQSQFDSLVSFAFNVGLVAFARSTLLRLLNAGDYGGAADQLLHWNKNDGAVMEGLTKRRQRERAMFLLPQHVTERSPVAPAPLEPPPEMPDRQQPASSLPPAPNLPPGKVFPSFPPAPQPTASKPMAPVLAALLPSLVSLLPELGKLFGSGSAVSERNVQAAGKVAEVVIAATQAPNLQGAIEAMERDPDARNAARIAVQAVWYELSESGGGGIDGARKTALAVTAAGDWRSLGFGVTLALLALLIVGGGGYMLWSLIHDPATTPEQRGMLIGALVALIGSPVAFFFGSSVSSRAKDSALVDQLGKR
Other Proteins in cluster: phalp2_37963
Total (incl. this protein): 62 Avg length: 342,5 Avg pI: 6,79
Protein ID Length (AA) pI
5hjd8 389 5,81431
11n2A 359 6,93870
11nYG 342 5,38609
14uxf 345 6,44431
17DxY 349 8,57928
1bnAz 273 5,41917
1wVrR 354 6,21622
1xNJn 350 8,85713
1xOTG 211 9,46198
2ZRNT 342 5,91884
30Qi5 354 5,72087
30VtF 347 5,87547
30gHb 351 6,67923
3bfrc 348 8,86713
3g8Gy 342 5,75014
46eN3 352 8,56406
499b5 353 5,59849
4Kozr 355 5,80317
4MrZE 335 5,66369
4Mrxj 359 7,90307
4Na29 329 7,93304
4OEYo 395 5,71734
4UUo7 343 4,90273
4aWqd 346 5,70382
4bDm5 354 5,63100
4baHb 351 9,01914
4ekDs 345 5,76151
4fTRG 351 5,66022
4m3UQ 346 5,95146
4ncfC 362 9,06073
4nwS3 354 7,79792
4ouQ1 346 8,54337
4pqoQ 362 7,82835
50hMI 360 6,36087
520XO 269 9,18244
52a0u 345 8,82445
563KW 360 6,22145
5BwRI 346 5,34454
5GLzF 260 5,83369
5aIoM 345 7,90700
5awBa 346 8,52918
5c1kI 360 8,47258
5l2it 345 5,54370
5lDRm 341 6,15216
5mEX7 360 6,35803
5uvmh 376 6,60409
5vlsJ 363 8,57953
5zfec 354 6,78182
6PREX 341 4,93160
6Q12L 333 6,36860
6Q45W 346 7,72444
6U7vk 326 5,30270
6W1fZ 363 6,11834
7VvFn 321 6,06747
8eGfr 364 5,63794
8ip5a 357 5,66141
8j3Cv 360 4,98605
Q6gE 355 6,78376
UtId 358 6,93779
qxjT 374 6,37543
uKIK 358 6,66962
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37960
5fckM
 10 36,7% 392 2.063E-85
2 phalp2_20036
1pDJr
 122 33,3% 417 2.090E-67
3 phalp2_7444
4LgFk
 65 37,4% 270 1.337E-42

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Representative sequence (used for alignment): 5hjd8 (389 AA)
Member sequence: A0A6J5LRB2 (155 AA)
1 389 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796316 [NCBI]
CDS location
range 33695 -> 34162
strand -
CDS
ATGATGACATTCTCCAATAAAGGCTTGGCCTTTTTAAAAAAAGCCGAACACTGCGTCCTGACGGCATACAAAGATCCGTTGTCAAAGACCGGGCTCCCGATAACAATCGGATACGGCTCAACTATGAACACCAACGGAACCAGGATAAAGCTAGGAGACAGAATAACCCAGGCGCAAGCCGAAGAGCTGCTCGCATGGGAGGTAAGCAAAAAGAGCATGATTTTAAATTTCTGCGAATTGAAGGTGACACAGGCGCAATTCGACGCCATCGTCCTGCTGACATACAACATAGGCGTCGGCGCTTTCAAAGACAGCACGCTGCGCAAAATGATAAAGAAAAACCCCGAGGATCCTGCAATTGAAGCGGAGTGGCTAAAATGGCATTTTGCAGGCGGGATCCCTTCCAGGGGCCTAATGAACCGCCGCAAAGGGGAATACAAAATATACAGCAAATCGGAATACTCATAA
CDS Source ID
[NCBI]
CDS Source
LR796829 [NCBI]
CDS location
range 33695 -> 34162
strand -
CDS
ATGATGACATTCTCCAATAAAGGCTTGGCCTTTTTAAAAAAAGCCGAACACTGCGTCCTGACGGCATACAAAGATCCGTTGTCAAAGACCGGGCTCCCGATAACAATCGGATACGGCTCAACTATGAACACCAACGGAACCAGGATAAAGCTAGGAGACAGAATAACCCAGGCGCAAGCCGAAGAGCTGCTCGCATGGGAGGTAAGCAAAAAGAGCATGATTTTAAATTTCTGCGAATTGAAGGTGACACAGGCGCAATTCGACGCCATCGTCCTGCTGACATACAACATAGGCGTCGGCGCTTTCAAAGACAGCACGCTGCGCAAAATGATAAAGAAAAACCCCGAGGATCCTGCAATTGAAGCGGAGTGGCTAAAATGGCATTTTGCAGGCGGGATCCCTTCCAGGGGCCTAATGAACCGCCGCAAAGGGGAATACAAAATATACAGCAAATCGGAATACTCATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5hjd8) rather than this protein.
PDB ID
5hjd8
Method AlphaFoldv2
Resolution 71.27
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50