Protein

Protein accession
A0A6J5L255 [UniProt]
Representative
6AjRb
Source
UniProt (cluster: phalp2_36745)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 93% (predicted by ML model)
Protein sequence
MKFSKEGFQLLSLFESFRSESYQDEGGVWTIGYGHTKGVSKESKPISKNEAFQFAREDIEAVEKFLSFHLPTLTQKQFDALVSFIFNIGLHAFENSMMYKDCLLAGKMDYAADEFDEWIYVKRKISKGLKRRRAIEKKMFIGRHTYEELIHLWKKGII
Physico‐chemical
properties
protein length:158 AA
molecular weight:18523,2 Da
isoelectric point:8,85
hydropathy:-0,39
Representative Protein Details
Accession
6AjRb
Protein name
6AjRb
Sequence length
102 AA
Molecular weight
11613,28190 Da
Isoelectric point
5,86115
Sequence
MKFSQKGEKILKEVEGFLEKEKLDDGGWSTIGYGHKIKAGEYFTTITPEIGIKILHNDVVTIESFINHYLPRVTQNQFDALVIFIFNIGITAFLNSSIFMNI
Other Proteins in cluster: phalp2_36745
Total (incl. this protein): 2 Avg length: 130,0 Avg pI: 7,36
Protein ID Length (AA) pI
6AjRb 102 5,86115
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_126
5jCCA
 637 42,1% 102 2.842E-23
2 phalp2_2632
6RhYr
 14867 43,7% 96 4.910E-22
3 phalp2_33221
5jbqV
 447 41,2% 97 2.011E-19
4 phalp2_8712
860Ko
 6 43,2% 97 5.199E-19
5 phalp2_4451
31DIk
 4919 39,8% 108 7.135E-19
6 phalp2_26644
2b0IA
 24 39,7% 88 1.233E-17
7 phalp2_9019
535M3
 35 38,2% 94 8.237E-17
8 phalp2_31530
48EM7
 20 40,0% 100 7.554E-16
9 phalp2_13608
5ojL2
 3 31,9% 97 1.196E-13
10 phalp2_31263
8mZo1
 167 39,0% 100 1.196E-13

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 6AjRb (102 AA)
Member sequence: A0A6J5L255 (158 AA)
1 102 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796199 [NCBI]
CDS location
range 309 -> 785
strand -
CDS
TTGAAATTCAGTAAAGAAGGATTTCAACTACTAAGCCTCTTCGAATCCTTTCGTTCTGAATCTTATCAGGACGAAGGTGGTGTGTGGACAATAGGATATGGTCATACAAAAGGTGTTTCTAAAGAGTCTAAACCTATCAGTAAGAATGAAGCTTTTCAGTTTGCGCGTGAAGATATCGAAGCTGTGGAGAAGTTTCTTTCTTTTCATTTACCGACTCTAACTCAAAAACAATTCGATGCTCTTGTATCTTTCATTTTCAACATCGGGTTACATGCATTCGAAAACAGCATGATGTATAAAGATTGTTTACTTGCTGGAAAAATGGATTACGCCGCAGATGAGTTCGATGAATGGATTTATGTAAAGAGAAAAATAAGTAAAGGACTAAAAAGACGACGTGCGATTGAGAAAAAAATGTTTATCGGACGTCATACCTACGAGGAGTTAATACATTTGTGGAAGAAAGGTATTATATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6AjRb) rather than this protein.
PDB ID
6AjRb
Method AlphaFoldv2
Resolution 94.89
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50