Protein

Protein accession
A0A6J5KQM7 [UniProt]
Representative
ZMDf
Source
UniProt (cluster: phalp2_22463)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
VAL
Probability: 99% (predicted by ML model)
Protein sequence
MTNLRRDIETPDYYALQPQGRAQLFDKVYMGIVKETQDDKHMGRLKVWIPEICGGDGQDSDTWLQMNYCSPFAGATSVYKNKPNSQNYSDSQISYGMWFVPPDIENQVICMFINGDASKGIWIGCMYQWNMNNMVPGIAGDLGAPSAPVVEYNKRNTYSGDPDTTTRPEYAPLRDGLLAQGLLNDPVRGVTTTSARRNNPINNAYGFLTPGGNQVVFDDDPNNQFIRLRTQHGAQVLVNDNTGCVYMNSVDGKNWVELSAGGEIDVYAQADISIRTGGSLNLRADLDINIEAGRSIFMVARDEAQAAAPDISILLDVTDATNLIIGKPAYTYQGQWQSSATGQISNASVVFNDGLIVEFRRNIDNAFNLISYTVSGVNTAIQLTPTPTKLNTNGGGLIKMAAAQDFHASSQKNMYITSQKEMHRASGSNMFDTAYGNFDRKAGGYIHDTTSGDFGVLSAGNFVLSAPRVDVNGPSAPSAKIATPATTPVSLSQKDMQIITEGEFRYVLINTIMPRLPYHEPYTGHDARTFGLNGNVEQSPAGSSPPLLSGQIIAGQTKPLDIIGSPKAGMPPGRYIGEGYDDKGQPIYKYVGSGTDLAAAGSYSISSNLVEFVKRHEGLKASVYLDPKGLPTVGYGHLLTAAENASKTILIGGINVPLTRPLTQTECDTLLSQDLYHDGVVHIQRQVKVPLTQAQFDALVSFVFNVGSGKLANSTLLKQLNQGNYADVPPELMQWTGIPVLKGLVTRREAEASMFQGRYPKNA
Physico‐chemical
properties
protein length:763 AA
molecular weight:82802,1 Da
isoelectric point:5,49
hydropathy:-0,31
Representative Protein Details
Accession
ZMDf
Protein name
ZMDf
Sequence length
1130 AA
Molecular weight
119754,74970 Da
Isoelectric point
5,30378
Sequence
MPIPSRTITSPKAYTLAPDGRATQLDKIYVGFIKSTDDTQRMGRLRVWIPEVSGDPNDESQWFTMNYASPFAGATNPYNNTSGTAWTDSQRSYGFWFVPPNLENEVICCFINGDPGRGIWFGCLYQQYMNFMVPGLAGTPESNGLPVSEYNKLDPNLNTVNPKRPLYTPLSDALKIQGLDKDDIRGLSTATARSNNPPNAVFGILTPGGSQMVFDDDPSGKYIRMRTQTGTQVLINDTEGLIYMTTRDGNNWIEMSADGTITAYSAADINIRSQGTLNLRADIDVRIEAGRSIYMKARGEVGTRSTQGTADTTGQSQTATTTNTAQVPAIGVNDSTVTIKVPTSSITGTFVQGMNISGIPWANPVTNTAPPTTGPVSGYPSNMSQSEIESIISNEATLRGIDPNVAINVFRHEGAGSYQSLVPRSGNGSYNGREASFGPYQLFTGVGLGNAYESQTGRSLMTDNTQDGITNQIRFALNNAVTGGWGQWYGAAAGGVSARQGLNGAHVVNNVNNSPYTSNTQPSTVPVPDVAGSGQPTVVVGDSIAVGTGPALANLRQGVVTSATVSATSSAIASSAANNTSIQNAQWAVVSAGSNDDVTTNSGKGLLTSNLFSIRTSLNAQNYTWILPKDTTRREVVYGFAKGKGDNVADIGASTDGVHPKNYTELANNVNATIATQTNAPNNTPNTNSTAAVNNPTVGVQLASFSTDGDYTLLNVSFQPGNHSAASNASVITGTLQVTPNNTEQPTTNYNSTDGGMIMINAVKDMHLYANRDMYQTSDGRTARTAKTSLFDYSYGSYDVAVGGYLTLQSNGLMSLGTSANMVLQGTRVDINGPAASGALSAPSAKEPIDSFQQDNEVLAPGQFRFVVKNTILSALAYHEPYANRGTGQSAQGRVESGPVFDSNGLSIPSGASTSGAARPLDLLGSPNPNSKAGYYTGTGYDSKGQPQYTYVSPPNGQQVPAGQLSLSPAGVNFLVGNEGARSTLYDDVGHPAIGYGHDLLPDELAGQYVNILGTKRSLNAGPLSADEITGLFRTDAAPREQQIRTWCKVPISQTQFDMLFSLVYNVGYPKSVFAKLNTGDYNVGTEWQSYHYATIKGTKQSLPALVTRRAAEWQNFSGGQPINPSGSYS
Other Proteins in cluster: phalp2_22463
Total (incl. this protein): 42 Avg length: 1043,3 Avg pI: 5,18
Protein ID Length (AA) pI
ZMDf 1130 5,30378
187t5 927 5,55393
18NR1 1162 5,19164
18lDW 977 4,95655
18nzd 1130 5,05727
1ACGc 1132 5,19891
1hrDB 978 4,93706
20fIR 979 4,78342
20uZz 1154 4,99543
24z2V 1178 5,38961
2F0Rq 1160 4,98804
2F40F 980 5,16231
2NwXs 980 4,80008
2ZBvC 1130 5,30378
2bBXc 805 4,89045
2bDA3 980 4,85970
2bFBe 1156 4,89295
2bFmi 1124 5,13383
30A0y 977 4,95911
31wMH 880 4,94371
35LV 980 4,76410
35Xts 979 4,90835
35ZEW 900 5,03567
47jej 1155 6,42908
47kbC 1164 4,97991
48SWm 1164 4,89562
48V0u 1167 5,16504
48kCs 1111 5,38751
4J8lp 1211 5,60361
4d3BD 1157 5,14912
4rex3 979 5,06944
5BqXl 1169 5,47788
5ISQb 941 5,41433
6KEOL 958 5,42087
6LH92 1190 5,49891
6LQdP 1198 5,89042
806uK 1217 5,59287
TLio 702 4,51287
d21B 927 4,92063
epTt 941 5,41161
mV5Z 927 5,38989
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1713
2jRjO
 51 24,4% 1188 9.404E-130
2 phalp2_39277
48WgX
 7 22,0% 1180 5.600E-65

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796167 [NCBI]
CDS location
range 267833 -> 270124
strand +
CDS
ATGACAAATTTAAGAAGAGATATCGAAACCCCCGACTATTATGCGTTGCAACCGCAGGGAAGAGCGCAACTCTTTGACAAAGTCTACATGGGGATAGTTAAAGAAACTCAAGACGACAAACACATGGGCAGGCTGAAAGTTTGGATACCTGAAATCTGTGGGGGTGATGGCCAAGATTCTGATACATGGTTACAAATGAATTATTGCAGCCCGTTTGCTGGTGCCACAAGTGTTTACAAAAATAAACCCAATAGCCAAAATTACTCTGATAGTCAGATCAGTTATGGTATGTGGTTTGTGCCACCGGACATAGAAAATCAAGTTATTTGCATGTTTATTAATGGAGATGCAAGTAAAGGGATCTGGATTGGGTGTATGTATCAATGGAACATGAACAACATGGTGCCGGGCATTGCTGGTGATTTAGGAGCCCCTAGTGCACCTGTTGTAGAATACAACAAGAGAAATACGTATTCCGGTGACCCTGATACGACTACACGTCCTGAATATGCTCCTCTTAGAGATGGCCTACTTGCCCAAGGTCTGTTAAACGATCCAGTTCGTGGTGTCACCACTACCAGTGCCCGCAGAAACAACCCCATTAATAATGCCTATGGATTTTTAACACCAGGTGGTAACCAGGTGGTATTTGACGACGATCCCAACAACCAATTCATAAGGTTGCGCACACAACACGGTGCACAGGTGTTGGTGAACGACAACACTGGATGTGTATATATGAACAGTGTGGATGGCAAGAACTGGGTGGAACTCAGTGCGGGCGGGGAAATCGACGTTTACGCCCAAGCTGACATCAGCATCCGCACCGGAGGCAGTTTGAATTTAAGAGCCGATCTGGACATCAACATCGAAGCTGGACGCAGCATTTTCATGGTGGCTCGTGACGAAGCCCAGGCAGCCGCACCAGATATCAGCATATTGTTGGATGTGACAGATGCAACCAATCTGATTATTGGAAAACCTGCATATACATATCAAGGTCAATGGCAAAGCAGCGCAACTGGGCAAATCAGCAATGCCAGTGTAGTGTTTAATGATGGCTTGATTGTGGAGTTTCGTCGAAATATTGACAACGCCTTCAACCTCATAAGTTACACTGTGAGTGGAGTAAACACTGCCATACAATTGACTCCCACCCCCACTAAATTAAACACCAATGGCGGTGGATTAATTAAAATGGCAGCCGCACAAGACTTTCACGCATCAAGTCAGAAAAATATGTATATCACCAGCCAGAAAGAAATGCACAGGGCCAGTGGCAGCAACATGTTTGACACTGCATATGGAAATTTTGATCGCAAGGCTGGTGGATACATTCACGACACTACCAGCGGGGATTTTGGTGTGCTCAGTGCAGGGAATTTCGTGTTGAGCGCTCCCAGGGTGGATGTAAACGGACCCAGCGCACCCAGCGCAAAGATCGCCACTCCAGCAACCACTCCCGTCAGTTTGTCACAAAAAGACATGCAAATTATCACCGAAGGAGAATTCCGGTATGTATTGATCAATACAATCATGCCGCGCTTGCCATACCATGAACCATACACTGGGCATGATGCCAGAACATTTGGGTTAAACGGCAACGTAGAACAGTCTCCAGCTGGATCTTCTCCCCCGTTGCTTTCAGGACAAATTATTGCCGGTCAAACCAAACCTCTTGATATCATTGGCAGCCCCAAGGCTGGTATGCCGCCAGGAAGATACATTGGTGAAGGATACGACGACAAAGGTCAACCCATATACAAATATGTAGGATCCGGTACTGATCTCGCAGCAGCAGGCAGTTACTCAATTTCATCCAACTTGGTGGAATTTGTCAAGAGACATGAAGGGCTCAAAGCCAGTGTGTATCTTGATCCCAAAGGACTGCCCACAGTGGGCTATGGTCATTTGCTCACTGCGGCTGAAAATGCCAGCAAGACTATCTTGATTGGTGGTATAAACGTCCCCCTGACCCGACCATTGACACAGACCGAATGTGACACTCTGCTAAGCCAAGACTTATATCACGACGGTGTGGTCCACATCCAACGCCAAGTCAAAGTGCCACTGACACAAGCTCAATTTGATGCACTTGTGAGTTTCGTGTTCAACGTGGGATCAGGAAAGCTTGCCAACAGCACTTTGCTCAAACAGTTAAACCAAGGCAATTATGCCGACGTGCCACCAGAGCTTATGCAATGGACAGGAATACCAGTGCTAAAGGGACTGGTAACCCGTCGCGAAGCCGAAGCCAGCATGTTCCAAGGCAGATACCCCAAGAACGCCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (ZMDf) rather than this protein.
PDB ID
ZMDf
Method AlphaFoldv2
Resolution 75.02
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50