Protein

Protein accession
A0A6G5YMU9 [UniProt]
Representative
13DUc
Source
UniProt (cluster: phalp2_4019)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MANSNGIDVSSYQSGINIKAIAGDFVIVKATQGVNYTNPYMYKQLNDTKASGKLLGLYHFANAGNWKAEADYFLRAVKPYMNNCVLVLDYEGGAVPIGRESWAKSFLDYVYKQTGTKPMIYMGLADENAYNWAGYGVTNYALWVAQYNSMNAVYGYSPRPLYGRLRNWKDLAMFQYTPNGYLPNYNAPLDLDVYYGKNSDWVKHTNNKTEENKEMAWSVKVAPTDWGAILITKKSGLAIYSQPDNDHRIGTKKLAYNTSWRVSKYKDGFVRVAKTTDKDGTVHEQWIDSTGGVLKGNPTDSPNYRHFTIFLAAGAKAKLHKKPAGEVYGKELPAGTKFKAEFYDKKTGYFAVKDTKGKLVYVNGAKFLVLLGGN
Physico‐chemical
properties
protein length:374 AA
molecular weight:41877,0 Da
isoelectric point:9,38
hydropathy:-0,48
Representative Protein Details
Accession
13DUc
Protein name
13DUc
Sequence length
356 AA
Molecular weight
38395,76580 Da
Isoelectric point
6,22850
Sequence
MALNGIDISSWQAGIDLSVVPCDFVIIKATQGTGYTNPDYARAYAQAKAAGKCLGVYHYAEGGSPTAEADYFIKQVGSRIGECILVLDWEGEQNPAFGVNDYAWCKAWLDHVASKTGVKPMLYVSQSTMGMFSGIGDYALWVAQYADMNPTGYQATPWNEGAYDCAMRQYSSCGRLAGYAGNLDLNKFYGDRESWSRYAGKGNATDIGAQVNSSGMYYRAHCSNIGWLDSVRDGQTAGTTGRGIAMEAFKITPPEGMVIDVKAHIQDVGWKTYSGVKRGKSSGEGSSKNDPIIGSVGRARRLEAFELCIAENPKNLKVSYRAHIQDYGWTGWVPAGYAVGTVGCGLAIEAVQIKAV
Other Proteins in cluster: phalp2_4019
Total (incl. this protein): 70 Avg length: 359,6 Avg pI: 6,74
Protein ID Length (AA) pI
13DUc 356 6,22850
1cDBl 357 4,05998
1cIF1 352 4,05003
1kewo 442 9,41047
2VnQ6 316 6,69583
2llzG 373 9,64771
38Pgp 316 8,77797
3ZJNs 315 6,88976
3gMsL 356 4,75597
40EB2 317 8,24391
4CJP3 334 4,71095
4CLEd 289 4,46774
4Ey39 320 8,83238
4MiAV 353 5,27695
4SFfx 469 4,75466
4TtnQ 367 4,09669
5HJLs 378 5,73212
5HKLA 362 4,15768
5HKMi 378 5,29060
5HKW7 331 4,37640
5HLSe 370 5,42718
5WDAP 331 6,09475
5YNVG 331 6,22776
5ZGIG 344 4,67270
5ZzM9 373 5,56530
5oJCe 370 6,37241
5oKMr 440 9,59246
5tWDM 408 4,80837
5tWJe 378 9,01289
5tWSf 377 6,12727
5twLZ 378 9,14118
61cRz 373 5,77145
68Yhl 320 4,70987
6Anpq 312 9,73539
6AnvP 454 9,26690
6HA3y 440 9,53676
6MjW 331 4,60819
6eetf 376 6,35871
6g3Xk 331 5,80482
6hONb 328 9,18328
6jNER 350 8,60642
6rd9Y 343 5,15015
6wc16 373 5,77481
73bNM 374 9,62863
74AQ9 327 4,94286
7BJaD 331 6,68810
7BOOs 426 9,28611
7BYcD 455 9,41549
7Bbvo 438 9,33762
7dmNs 327 4,90204
7fsgR 332 4,70714
7krQQ 327 6,36480
7pm1N 324 6,07162
7qVhh 329 4,92154
7qxkg 324 5,64897
7sQN9 458 9,44167
7suBJ 455 9,42046
7t99k 331 8,49392
7tEb6 407 9,52109
7uoSN 332 4,96769
7vAT8 312 9,78116
7vTMU 379 8,99684
7y68C 356 9,42014
8deUd 373 5,44105
8dheJ 253 6,13022
D0ix 331 6,58067
KNzO 330 5,04630
wlgI 327 4,73198
xWeu 330 4,67253
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37341
8v6XY
 562 45,8% 227 1.128E-88
2 phalp2_36067
6rv4w
 74 46,6% 268 1.056E-79
3 phalp2_16579
7zIOC
 8 50,4% 228 2.528E-73
4 phalp2_33970
406sB
 17 31,7% 359 1.614E-59
5 phalp2_7616
5K90z
 6 33,3% 381 1.042E-58
6 phalp2_20244
8fkhf
 8 30,4% 361 5.446E-54
7 phalp2_29363
150JJ
 9 29,7% 373 6.999E-49
8 phalp2_24501
4L4WX
 2 29,4% 231 1.308E-34
9 phalp2_37809
4Ez2v
 8 32,3% 229 1.698E-32
10 phalp2_25751
4MCjU
 5 26,4% 238 5.369E-30

Domains

Domains [InterPro]
GH25
ChW
Representative sequence (used for alignment): 13DUc (356 AA)
Member sequence: A0A6G5YMU9 (374 AA)
1 356 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF07538

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacteriophage sp
[NCBI] 		38018 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN856100 [NCBI]
CDS location
range 96537 -> 97661
strand +
CDS
ATGGCAAACAGTAACGGCATAGATGTATCAAGTTACCAGAGTGGTATCAATATCAAAGCTATTGCTGGAGATTTTGTTATTGTCAAAGCAACTCAAGGGGTTAATTATACTAACCCTTACATGTATAAGCAATTAAATGATACTAAAGCGTCAGGTAAGTTACTTGGCTTATATCACTTTGCTAATGCAGGGAACTGGAAAGCGGAAGCCGACTATTTCTTACGGGCAGTTAAACCATACATGAATAATTGTGTCTTAGTACTTGATTATGAAGGTGGAGCAGTACCTATAGGTAGAGAATCGTGGGCTAAGAGTTTTCTAGACTATGTTTATAAGCAAACTGGTACTAAACCTATGATTTACATGGGATTAGCAGACGAAAATGCTTATAACTGGGCTGGTTATGGTGTTACTAACTATGCCTTATGGGTTGCTCAATATAACTCAATGAATGCAGTTTATGGCTACAGTCCTAGACCACTTTATGGGCGATTGAGAAACTGGAAAGACCTAGCTATGTTTCAGTATACACCTAACGGGTATTTACCTAACTATAATGCACCGTTAGATTTAGATGTGTACTATGGAAAGAATAGTGACTGGGTAAAGCACACAAATAACAAGACGGAGGAAAATAAAGAAATGGCATGGTCAGTGAAAGTGGCACCTACAGATTGGGGTGCTATCTTAATAACAAAGAAATCAGGGTTGGCGATTTATTCACAACCAGACAATGACCATAGAATCGGTACTAAGAAGTTAGCTTATAACACGTCTTGGCGTGTATCTAAGTACAAAGATGGTTTTGTCAGAGTTGCAAAGACTACTGATAAAGATGGTACTGTACATGAACAATGGATAGATAGTACTGGTGGAGTTCTGAAAGGTAACCCTACTGATAGTCCTAACTATCGTCACTTTACAATATTCTTAGCAGCAGGAGCTAAAGCTAAACTACATAAGAAACCAGCTGGAGAAGTTTATGGTAAGGAATTACCAGCAGGAACTAAATTCAAGGCTGAATTCTATGATAAGAAGACTGGCTACTTTGCAGTTAAAGATACAAAGGGCAAACTTGTATATGTAAATGGTGCTAAATTCTTGGTACTACTTGGTGGTAACTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (13DUc) rather than this protein.
PDB ID
13DUc
Method AlphaFoldv2
Resolution 90.03
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50