Protein

Protein accession
A0A6G5Y728 [UniProt]
Representative
5l2Hd
Source
UniProt (cluster: phalp2_35107)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGIRQTAKAVTCSLALVVSFFFADNEATKLSEEGLANIIDCEGCQRNDYVDQAGVRTVGVGSTSNVSPNTTISNSQVAVRLRKDTQVAEQCLARKVKVPLSQGEYDAYASFIINVGCYGFSTSTSYVILSEGGDRRKACYSMRRWNKITVNGKKVYNQGLANRREKDIKLCIKQL
Physico‐chemical
properties
protein length:175 AA
molecular weight:19251,7 Da
isoelectric point:9,21
hydropathy:-0,26
Representative Protein Details
Accession
5l2Hd
Protein name
5l2Hd
Sequence length
243 AA
Molecular weight
27583,87100 Da
Isoelectric point
8,96783
Sequence
MKLSASGLLFLKSLEDLRLKSYPDEGGVWTIGYGTTKNVVPDMEITEEKAEEFLIRDVRESEDCINQHVVAKLNQNQFDALVSFVFNVGINAFRQSTLLKKINCLKFDEVPAQMRRWIYVKNHINKGLINRRNFEINLFTESVVVKEAKKLVIKTNQVVNDVVVRTMFERIPLLAGLFKFIDGKKVLLGRLGLFATAILQAVIELYPDGPLGQSAVLALGALSWFLTEFGIRHKQDKELRGVE
Other Proteins in cluster: phalp2_35107
Total (incl. this protein): 3 Avg length: 215,3 Avg pI: 7,63
Protein ID Length (AA) pI
5l2Hd 243 8,96783
871Uj 228 4,71630
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33221
5jbqV
 447 43,0% 151 5.862E-35
2 phalp2_28113
7zmZV
 50 42,5% 155 8.003E-35
3 phalp2_38866
1Mo76
 29 37,1% 242 6.930E-29
4 phalp2_22247
7g4te
 1 36,7% 223 2.394E-28
5 phalp2_34307
3A2Hz
 178 40,0% 165 1.164E-25
6 phalp2_38353
ATmM
 19 35,8% 156 7.535E-23
7 phalp2_34948
4CY2e
 4 32,9% 167 7.169E-17
8 phalp2_4127
1EJtW
 7 33,7% 178 3.392E-13

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 5l2Hd (243 AA)
Member sequence: A0A6G5Y728 (175 AA)
1 243 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudoviricetes sp
[NCBI] 		2832643 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN855772 [NCBI]
CDS location
range 2492 -> 3019
strand -
CDS
ATGGGTATTCGACAAACCGCCAAGGCAGTCACATGCTCTTTGGCGTTAGTTGTATCCTTCTTCTTCGCAGACAATGAAGCTACAAAGCTGTCTGAGGAAGGACTCGCCAACATCATTGATTGTGAGGGATGCCAGCGCAACGATTATGTTGACCAAGCTGGCGTCCGCACTGTGGGTGTTGGCAGCACAAGCAACGTAAGCCCTAACACTACTATATCAAATAGTCAGGTTGCGGTTAGGCTACGTAAAGACACCCAAGTAGCCGAACAGTGCTTAGCACGTAAGGTGAAGGTTCCATTATCACAAGGTGAGTATGATGCTTATGCATCGTTTATTATCAACGTAGGCTGTTACGGTTTCTCTACCTCTACATCGTATGTTATCTTGAGCGAAGGTGGCGATAGGCGAAAAGCCTGTTATTCCATGAGGCGGTGGAATAAGATAACTGTGAATGGCAAGAAGGTGTATAACCAAGGACTTGCCAACCGTAGGGAGAAGGATATCAAGCTATGTATAAAACAGCTATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5l2Hd) rather than this protein.
PDB ID
5l2Hd
Method AlphaFoldv2
Resolution 84.13
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50