Protein

Protein accession
A0A5Q2W7B1 [UniProt]
Representative
2NCcc
Source
UniProt (cluster: phalp2_30061)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MLKGADISKYQGDVNFDQFKDAVDFVIIRSSYGVGYKDTKYVRNRDEARHVNLLRGFYHYAYPQHNTPEKEADWFLRVIGKPQEGELLALDFEEEYADPVNWSLKFLNFVSTKLDGYKPLIYINMNFNNRWNWHPVVNANYGLWLARWDFNPDTKPPQTDWPVVAMRQYTNQQNFAGIAGRVDGNVFYGETNDYLKYGFKGEEVSEPPSGDMEITNSTKIPASLLTGEAFKPENDMEVQAIRSTLNDQKRDLIAANQRIEELEGQVGEQQFSKPKAKHFYEIAKLEEQG
Physico‐chemical
properties
protein length:289 AA
molecular weight:33462,9 Da
isoelectric point:5,12
hydropathy:-0,72
Representative Protein Details
Accession
2NCcc
Protein name
2NCcc
Sequence length
323 AA
Molecular weight
36462,97400 Da
Isoelectric point
5,95396
Sequence
MAYTHGIDISKWQGDVDFARIKKATQFAIIKATEGVGYTDPKFKRNQEGFRNVGLPLGYYHFARPDLGNSAIAEADWFLKTVGNLRDGEILALDYEVSYGDPVNWCKAFLDRIKEKLGGYKPLIYINLSLNNNYSWSSVVKGDYGLWLAYYMSDGNNGLNSADKPAPATDWAFTAMRQYSSSGKVDGISGNVDMNTFYGDVPTLLKYGYKSPVVAPTPEPIPEPPVEPSELEKVKKELEIANTTIKTITEEKKLVEAELKTEKEESKELSNNYDVLFKEKERLATEKNEAIRLLSEYKNSDMGKLVVTLYEIWKQLKAKLSKK
Other Proteins in cluster: phalp2_30061
Total (incl. this protein): 23 Avg length: 293,7 Avg pI: 6,09
Protein ID Length (AA) pI
2NCcc 323 5,95396
1iVAQ 257 7,54949
2A3HX 328 8,78912
2Smqd 374 4,62808
35LWl 274 5,26945
4DsJ3 258 5,83506
4FqJc 288 4,82980
4Ft2O 272 6,13977
4GWjT 250 8,95506
4H8fB 365 4,76449
4IDvH 283 4,97736
4Nk9h 291 5,33038
5ISAr 295 5,45964
5JEGg 316 5,36517
5fgMF 260 5,18090
5jNOr 314 8,55510
5zN9i 239 5,33465
6AiZH 275 9,07755
6SNWN 296 5,86961
8dFAi 290 4,67679
8i7uk 334 4,68321
It8B 284 7,66294
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39009
8i5mw
 7 48,1% 243 1.992E-85
2 phalp2_37809
4Ez2v
 8 40,0% 235 2.445E-67
3 phalp2_5615
4g2xP
 40 46,6% 210 2.181E-66
4 phalp2_32821
2L8bh
 41 41,9% 248 1.943E-65
5 phalp2_39912
1jXPT
 300 42,9% 219 1.219E-61
6 phalp2_9153
6wSxJ
 7 34,3% 233 4.931E-52
7 phalp2_37341
8v6XY
 562 37,1% 229 1.253E-51
8 phalp2_4299
7ZuoI
 1 38,6% 230 3.185E-51
9 phalp2_27394
4HDMm
 9 41,7% 237 5.929E-51
10 phalp2_13003
3NS3t
 38 37,0% 224 4.588E-49

Domains

Domains [InterPro]
GH25
Unannotated
Disordered region
Representative sequence (used for alignment): 2NCcc (323 AA)
Member sequence: A0A5Q2W7B1 (289 AA)
1 323 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ctg2L5
[NCBI] 		2656712 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN582060 [NCBI]
CDS location
range 37604 -> 38473
strand +
CDS
ATGCTAAAAGGCGCAGACATTTCTAAATACCAGGGAGATGTAAACTTCGATCAATTCAAAGACGCAGTGGATTTTGTAATCATAAGAAGTTCATATGGAGTTGGCTATAAAGATACTAAATATGTGCGCAATCGTGATGAGGCAAGGCATGTCAATTTGCTTCGGGGCTTTTATCACTACGCCTATCCTCAACACAACACTCCAGAAAAAGAAGCGGATTGGTTTTTAAGAGTAATTGGAAAACCCCAGGAAGGTGAACTGCTTGCTCTTGATTTTGAAGAAGAATATGCTGATCCAGTAAACTGGTCTTTGAAGTTCTTAAATTTTGTAAGTACAAAGTTAGATGGATATAAACCCCTTATTTATATCAATATGAATTTCAATAATAGATGGAACTGGCATCCTGTGGTAAACGCAAACTATGGACTATGGCTTGCCAGATGGGATTTTAATCCAGATACCAAACCGCCCCAGACAGACTGGCCAGTAGTTGCTATGAGGCAATACACTAACCAGCAAAACTTTGCTGGAATTGCAGGCAGAGTTGATGGAAATGTATTTTATGGGGAAACAAATGATTACCTGAAATATGGATTCAAAGGAGAGGAGGTGAGCGAACCCCCATCGGGAGATATGGAAATAACAAACAGCACAAAAATTCCTGCAAGTTTATTGACAGGAGAAGCCTTTAAACCAGAAAACGACATGGAAGTTCAGGCTATCCGCTCAACCTTAAATGATCAAAAGAGGGATCTTATTGCTGCAAACCAGAGGATTGAAGAACTTGAGGGACAAGTTGGAGAACAGCAATTTTCAAAGCCTAAAGCAAAGCACTTCTACGAAATAGCCAAGCTTGAGGAACAAGGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2NCcc) rather than this protein.
PDB ID
2NCcc
Method AlphaFoldv2
Resolution 90.47
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50