Protein

Protein accession
A0A5Q2W272 [UniProt]
Representative
54HN1
Source
UniProt (cluster: phalp2_40646)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MLYSLQTKWLLLHLLLVSISVLVHGKRNVKASKEAIRLIKHHEGVRNKPYKCPAGLFTVGVGHLIGDGKTLPPEWNRTFTNEEIDGILKHDLNRFELGIHKMLPNVPLRQHEFDALVSFCFNLGLGCFQRSTIRQALLRGDKEAAMESLVKYCKAGGKILKGLQNRRLDERRLFLGV
Physico‐chemical
properties
protein length:177 AA
molecular weight:20119,5 Da
isoelectric point:9,85
hydropathy:-0,15
Representative Protein Details
Accession
54HN1
Protein name
54HN1
Sequence length
72 AA
Molecular weight
8233,40170 Da
Isoelectric point
6,24470
Sequence
MHLIGDGKSLPDSWNRTFTEAEIDGILKSDLRRFELGVHKMLPNVPLRQHEFDAIISFCFNLGLGCFQRSTL
Other Proteins in cluster: phalp2_40646
Total (incl. this protein): 6 Avg length: 142,5 Avg pI: 9,27
Protein ID Length (AA) pI
54HN1 72 6,24470
A0A6J5LY31 154 10,01344
A0A6J5MKS3 154 9,91512
A0A6J5P100 150 9,85536
A0A6J7WWN0 148 9,76440
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10449
29ppc
 1 52,7% 55 3.160E-14
2 phalp2_21292
1zbsP
 1 55,3% 47 6.561E-11
3 phalp2_28432
1IGqr
 1 45,0% 71 1.241E-10
4 phalp2_5479
3bNVe
 2 32,8% 64 6.783E-07
5 phalp2_31252
8ppPq
 1 42,8% 56 6.333E-06
6 phalp2_26644
2b0IA
 24 38,9% 59 1.121E-04

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 54HN1 (72 AA)
Member sequence: A0A5Q2W272 (177 AA)
1 72 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ct2cs2
[NCBI] 		2656707 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN582059 [NCBI]
CDS location
range 33460 -> 33993
strand +
CDS
ATGCTGTATTCTCTACAGACGAAATGGCTATTACTGCATCTATTATTGGTTTCTATTTCGGTTCTCGTACATGGGAAAAGAAACGTGAAAGCGTCTAAAGAAGCAATACGCTTAATTAAACACCATGAAGGTGTAAGAAACAAACCATACAAGTGCCCAGCAGGACTGTTCACAGTGGGAGTTGGTCATTTGATAGGTGATGGCAAAACATTGCCACCAGAATGGAATAGAACTTTTACAAATGAGGAAATAGATGGAATTCTTAAACACGACCTCAATCGCTTCGAGTTGGGAATACATAAGATGTTACCTAACGTGCCTCTTCGACAACATGAGTTTGACGCTCTTGTCAGCTTTTGCTTTAATTTGGGTCTTGGATGCTTTCAGCGTTCAACCATCCGTCAAGCGTTGCTTCGTGGAGATAAAGAAGCGGCTATGGAGTCGCTAGTTAAATATTGCAAAGCTGGTGGTAAAATATTAAAAGGCTTACAAAACAGAAGATTAGATGAAAGACGACTATTTCTTGGTGTATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (54HN1) rather than this protein.
PDB ID
54HN1
Method AlphaFoldv2
Resolution 62.03
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50