Protein

Protein accession
A0A4P8W8G2 [UniProt]
Representative
66E2C
Source
UniProt (cluster: phalp2_17564)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MAKLLYIADISKWQGNINFEQLKGQIDGLIIRIGYTGTADKKAHEDEKVRINVEGAEKAGIPYSFYYYSESNLPLTGNRAANFSINTFRDIQKDLGKTPHFTEIFFLDIENLKTLGIRSDGGALPEFEKVMKEKGFISGIYSNQSTFMTSLGDTPHSIRWVAKWSSIEPDIDYDIWQYTNCRYFRGIEGRVDCSKTYNTALIGNYEGEVEKLQDTIETVIDVLNERTKKLSRLLREDYKWQE
Physico‐chemical
properties
protein length:242 AA
molecular weight:27860,1 Da
isoelectric point:5,43
hydropathy:-0,53
Representative Protein Details
Accession
66E2C
Protein name
66E2C
Sequence length
540 AA
Molecular weight
59357,83120 Da
Isoelectric point
4,48809
Sequence
MSQRIIDVSEHDGTLDWQKIKDAGYHAIIRVGFGRFDSGGRLDYNLGTNVSECERLGIPYGFYWYSYATSTASAEIEGTQCVEAIKGYHPSYPVYFDAEEPGTEGVAQNNALVFCDVIRNAGYKPGIYSSESWWQNYLTDVSGVNRWVAKWSSYKPNVECDLWQYDSEAYVPGAGPADVNEVLNESMLPQTKTDPSEPKKCPYCGQPIPANPPKDDTPDVPSEDLPKQDVPEETGKLTYQQVAAEIMHHMVTHDGNGGHGYSQYQRWGDGTREVVTLSDGTQVSIPNGDFDCSSAVIEAWELALPGCTGNATYTGNMRECFLSTGLFEWHPMGDGYIAQTGDIYLNEVHHTAMCWSAEPDIMMQFSISETYGISGQQGDQTGWESNIKAYANYGNGGWDGKLVYIGPKRDGSSDKTPTVTPSTPDTMTQIDVDGYWGRNTTMALQNYFGTYADGEVWHQWAPNINRNGALTSGWMCDGTAKGSPVIRALQNVLGVTADGIIGTDTIMALQTRMGTYVDGTLDEGSTCVQELQRRLNAGTI
Other Proteins in cluster: phalp2_17564
Total (incl. this protein): 6 Avg length: 522,0 Avg pI: 4,62
Protein ID Length (AA) pI
66E2C 540 4,48809
5RK0K 638 4,45523
5T4of 540 4,46825
6t0xM 540 4,44728
8kPud 632 4,45262
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32938
3TLgl
 6 31,4% 499 1.344E-63
2 phalp2_11580
19jRu
 6 32,9% 401 1.576E-49
3 phalp2_24001
41ivD
 4 29,2% 561 3.790E-46
4 phalp2_15741
3tdUS
 229 27,5% 440 1.062E-31
5 phalp2_4039
19nTK
 10 26,8% 532 7.957E-27
6 phalp2_7267
3WKbo
 12 24,1% 563 1.840E-25
7 phalp2_37217
23tRW
 1 25,2% 447 5.005E-21

Domains

Domains [InterPro]
GH25
Unannotated
Unannotated
Representative sequence (used for alignment): 66E2C (540 AA)
Member sequence: A0A4P8W8G2 (242 AA)
1 540 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Capybara microvirus Cap3_SP_389
[NCBI] 		2585441 Petitvirales > Microviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK496778 [NCBI]
CDS location
range 2551 -> 3279
strand +
CDS
ATGGCTAAACTTTTATACATCGCAGACATATCAAAATGGCAGGGCAATATCAACTTTGAACAACTTAAAGGACAGATAGATGGCCTCATTATAAGAATAGGCTACACAGGAACAGCAGACAAAAAGGCACACGAAGACGAGAAAGTTAGAATCAACGTTGAAGGAGCTGAGAAAGCAGGCATTCCATACAGCTTCTACTACTACTCAGAAAGCAACCTGCCATTAACAGGTAACCGGGCTGCCAACTTCTCAATAAACACCTTTAGAGATATTCAAAAGGATCTGGGTAAAACACCACACTTCACTGAGATATTTTTCTTAGACATCGAGAACTTAAAAACACTGGGCATTCGCTCTGATGGTGGCGCACTTCCTGAATTTGAAAAAGTAATGAAGGAAAAAGGCTTTATCTCAGGTATCTACTCAAATCAATCAACTTTTATGACAAGCCTGGGCGACACACCGCACTCCATCAGATGGGTAGCAAAATGGAGCAGCATTGAACCAGATATTGACTATGACATCTGGCAATACACAAACTGCCGCTACTTCCGGGGCATTGAAGGAAGAGTAGACTGCAGCAAAACCTACAACACAGCACTCATAGGCAACTATGAAGGTGAAGTAGAAAAACTACAAGACACAATAGAAACAGTTATTGACGTTCTCAATGAACGGACTAAAAAATTATCAAGACTATTACGGGAGGATTATAAATGGCAGGAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (66E2C) rather than this protein.
PDB ID
66E2C
Method AlphaFoldv2
Resolution 83.28
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50