Protein

Protein accession
A0A345MNK0 [UniProt]
Representative
1js3Z
Source
UniProt (cluster: phalp2_36488)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MIISQQGIDLIKHYESCSLTAYRDSTGILTIGYGHTGRDVREGETISPDTANQLLVDDLQSFENMLNDRLDTDIEQYQFDALMSFLFNIGPGQTGVKDGLFCLKNGNPSTLWKMVQSSDFSSASKQFLLWNRAGGVVLRGLTYRRQSESLLFSTGELKFFN
Physico‐chemical
properties
protein length:161 AA
molecular weight:18065,1 Da
isoelectric point:4,93
hydropathy:-0,27
Representative Protein Details
Accession
1js3Z
Protein name
1js3Z
Sequence length
116 AA
Molecular weight
12397,83150 Da
Isoelectric point
5,69103
Sequence
VKISDSCIAIIKQFEGMETQAYPDPATGGAPWTIGYGHTGNDVRPGTVWNQAQAESVLRSDLARFEFLVNNALTTVVNQNQFDALVSFCFNVGPGKKGVKDGLLVLKNGNPSTVSP
Other Proteins in cluster: phalp2_36488
Total (incl. this protein): 12 Avg length: 119,9 Avg pI: 6,84
Protein ID Length (AA) pI
1js3Z 116 5,69103
1YSNG 102 4,28654
4FzF4 153 8,26228
6DJQC 101 6,54350
6KxwN 104 9,26193
726pT 104 9,12371
7VxKz 116 6,99537
7sPc3 163 9,81030
8FSw 111 4,65059
8karU 99 7,93549
QL1S 109 4,53475
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31530
48EM7
 20 47,4% 99 4.170E-31
2 phalp2_26644
2b0IA
 24 49,4% 91 2.026E-30
3 phalp2_9226
6S6V5
 37 43,2% 134 1.350E-29
4 phalp2_4451
31DIk
 4919 45,0% 100 1.032E-26
5 phalp2_26357
1kvxM
 28 44,7% 114 1.941E-26
6 phalp2_20450
3rDzg
 26 45,9% 98 2.663E-26
7 phalp2_18221
4OkMH
 137 39,3% 117 3.051E-24
8 phalp2_35600
1fedL
 106 48,0% 77 6.575E-22
9 phalp2_40213
2kZ5j
 4390 38,0% 113 1.697E-21
10 phalp2_4289
84eDR
 22 46,5% 86 3.192E-21

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 1js3Z (116 AA)
Member sequence: A0A345MNK0 (161 AA)
1 116 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudoviricetes sp
[NCBI] 		2832643 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH622943 [NCBI]
CDS location
range 107545 -> 108030
strand -
CDS
ATGATAATATCACAACAGGGTATTGATCTTATAAAACATTATGAATCATGTTCATTGACAGCATATAGAGATTCTACTGGAATTCTTACTATAGGTTATGGTCATACTGGAAGAGATGTAAGAGAAGGTGAAACTATATCTCCTGATACAGCTAATCAGTTATTGGTAGATGATTTGCAATCTTTTGAAAATATGTTAAATGATAGATTAGATACAGATATTGAGCAGTATCAATTTGATGCATTAATGAGTTTTTTATTCAATATTGGGCCGGGACAGACTGGTGTTAAAGATGGTCTATTTTGTTTAAAAAATGGAAATCCATCAACATTATGGAAAATGGTACAATCATCTGATTTTTCATCAGCTTCAAAACAATTTCTATTATGGAATCGTGCTGGTGGTGTGGTACTACGTGGACTAACATATAGAAGACAATCTGAAAGTTTATTGTTTTCTACTGGAGAATTGAAATTTTTTAATTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1js3Z) rather than this protein.
PDB ID
1js3Z
Method AlphaFoldv2
Resolution 93.23
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50