Protein

Protein accession
A0A345BQX2 [UniProt]
Representative
2cctI
Source
UniProt (cluster: phalp2_39083)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MVEGRSPVSARQRIAAGLLTMSLAGFGAWKVNEGYTDVAVIPTKGDVPTIGHGSTRWEDGTRVRMGDTITRPRAEVLARNLLTQDEKAFAASLPGVKLHQAEFDLYMDFVGQYGIGNWRASSMRRDLLTGNYAQACHNLLKYKFAAGYDCSTPDNKRCWGVWERQLKRHQQCMAEQP
Physico‐chemical
properties
protein length:177 AA
molecular weight:19780,3 Da
isoelectric point:9,14
hydropathy:-0,46
Representative Protein Details
Accession
2cctI
Protein name
2cctI
Sequence length
254 AA
Molecular weight
27860,56870 Da
Isoelectric point
9,81862
Sequence
MGTREVAVEAAKATPPAAVVAANKVMGLDLPTIVALVTLLYLLIQIGHLLWKWRNEATDRRKRNLYVERDRRRQRGAADRVLVSALALSLAGFAAWMASEGSSPAVVVSGETRLAPHIPTAGDVPTIGHGATHYEDGRPVRLTDPPISQARAETLARNLLSEDERRFKASLPGVALHQAEYDLYVDFVGQYGIGTWNKSSMRRALLAGNHPAACNALLRYRYAAGYDCSTPGNRRCAGVWARQQARHKRCLEVQ
Other Proteins in cluster: phalp2_39083
Total (incl. this protein): 5 Avg length: 191,2 Avg pI: 9,41
Protein ID Length (AA) pI
2cctI 254 9,81862
A0A345ANS5 175 9,45482
A0A6M5CBT5 181 9,65783
A0A345MKX1 169 8,96099
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33447
7bNjX
 23 61,7% 188 9.473E-82
2 phalp2_15849
4kKIv
 1444 55,1% 176 5.832E-68
3 phalp2_8252
7B99h
 46 31,5% 190 1.994E-11
4 phalp2_26423
1LaGk
 3 29,7% 175 6.526E-11

Domains

Domains [InterPro]
Disordered region
Unannotated
GH24
Representative sequence (used for alignment): 2cctI (254 AA)
Member sequence: A0A345BQX2 (177 AA)
1 254 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ctdb7
[NCBI] 		2675443 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH593831 [NCBI]
CDS location
range 33781 -> 34314
strand +
CDS
ATGGTGGAAGGCAGATCCCCAGTGAGCGCCCGACAGCGCATTGCCGCGGGTCTCCTGACGATGAGCCTTGCTGGATTTGGCGCCTGGAAGGTCAATGAGGGATACACCGACGTTGCTGTCATCCCCACCAAGGGTGACGTGCCTACCATCGGCCACGGCTCGACGCGCTGGGAGGACGGCACCCGCGTCCGCATGGGTGACACCATCACCCGCCCGCGTGCCGAGGTTCTGGCCCGCAACCTGCTCACCCAGGACGAGAAGGCTTTCGCCGCCAGCCTGCCGGGCGTGAAGCTGCATCAGGCCGAGTTCGATCTGTACATGGACTTCGTCGGCCAGTACGGCATAGGTAACTGGCGGGCTTCCTCGATGCGTCGCGATCTGCTGACCGGCAACTACGCCCAGGCCTGCCACAATCTGCTCAAGTACAAGTTCGCTGCCGGATACGACTGCAGCACGCCCGATAACAAACGCTGCTGGGGTGTTTGGGAGCGACAGCTGAAACGGCACCAGCAGTGCATGGCAGAACAGCCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2cctI) rather than this protein.
PDB ID
2cctI
Method AlphaFoldv2
Resolution 90.29
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50