Protein

Protein accession
A0AAU6PXR5 [UniProt]
Representative
4CbZx
Source
UniProt (cluster: phalp2_35819)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSKVQFKPRAVTEAIFVHCSATKATMNVGLREIRQWHKEQGWLDVGYHFIIRRDGTIEEGRPVDVVGSHVKDWNSKSVGVCLVGGIDEKGKHEANFTPAQMQSLKEKLADLKDLYPDAEIKAHHDVAPKACPSFNLSRWLKTGELVTSDWG
Physico‐chemical
properties
protein length:151 AA
molecular weight:16953,2 Da
isoelectric point:7,77
hydropathy:-0,45
Representative Protein Details
Accession
4CbZx
Protein name
4CbZx
Sequence length
239 AA
Molecular weight
26094,43340 Da
Isoelectric point
8,96615
Sequence
MRRRSTDHLVLHCSATPPTADIGAAEIRQWHKAKGWNDIGYHLVIRRNGEVEEGRSLEEIGSHVRNHNASSVGICLVGGVDARQRPRNNFTTAQWNSLKDRLAGLQSRFPASRVIGHRDFPGVAKACPCFDAIDWAEANGFRVAARLQPVTSSMLRAVRREMEDGDEVDDVASVPITGPGKWLAAILGSGGAGSLAGFGYGMDWVSLLVLILGLASMTCGVLLAIGRERRERLWDRLFG
Other Proteins in cluster: phalp2_35819
Total (incl. this protein): 312 Avg length: 154,6 Avg pI: 8,59
Protein ID Length (AA) pI
4CbZx 239 8,96615
11JEy 262 6,65360
11JuK 245 8,92747
3e2WQ 195 9,50059
4Cc6G 253 8,70550
4QdnV 204 9,09696
6g1vR 155 9,30068
7vGJF 239 9,07426
7vxTI 254 7,03504
7ynoV 254 8,22605
OW8K 239 8,94700
A0A7G9UTD9 151 8,80814
A0A5P1KKN4 151 8,46736
A0A3S7N8P7 152 9,05138
A0A345AQF2 152 7,78741
Q859G4 146 9,43625
A0A1Z1LW00 152 8,45459
A0A384WIG2 152 8,82561
A0A2D3QLT6 152 8,44234
A0A2U8USP6 151 8,46736
A0A1L7DRY8 149 9,37501
A0A1V0E671 151 8,80814
A0A1S6KVG4 153 8,48077
A0A2Z4QJC6 153 9,07330
L7TML5 203 9,37933
A0A3G1L2Y1 151 8,44544
B4YQF1 153 8,74664
A0A0K2FHF0 151 8,82606
U5P3N2 151 7,76275
A0A1A8YFJ2 152 8,46736
A0A0D3QHM9 151 7,00878
B6Z9F7 151 7,79096
A0A0A0YSJ1 153 8,80852
E9KIF2 153 8,82567
A0ZXJ1 151 6,70077
A0A0P0M6F9 151 8,80820
E5L7D0 151 6,64694
G0YQ57 149 8,72014
A0A192Y9Z6 153 9,29952
A0A0S2MVL1 146 9,27031
A0A1I9SFB3 151 8,80814
A0A2D0PEC9 151 8,44234
A0A2D0PDZ5 151 7,05084
V5YTT7 155 8,72053
A0A172JGD2 152 8,82606
A0A250KAW4 149 9,60168
W6PPL3 152 8,99329
A0A140XFM4 151 7,05204
D1L2U8 151 7,78747
A0A172JGI4 152 8,80807
A0A4D6DY24 151 8,80852
D3W693 151 7,09029
W6PPG5 152 7,79289
A0A172JGF2 152 8,45459
A0A2H4YGY2 146 9,37578
A0A2L0HPG5 152 8,82548
A0A1I9SF63 151 8,80814
A0A219YHE7 151 8,46736
A0A2Z5H3G7 149 9,54495
B3VCN8 151 7,79618
B3VCU5 152 8,45627
F8R4R2 151 8,46736
A0A1B2AN95 153 7,75923
A0A2S1PDH0 153 9,07330
A0A384ZVV7 151 8,72053
A0A344UBY9 151 8,80794
A0A3G8F3A2 151 7,79083
A0A3S9U868 166 9,37404
A0A4D6DRQ9 151 7,75764
A0A0D3QHK9 151 7,77202
A0A170PBB1 146 9,40454
A0A1B0TR30 152 7,78741
A0A1J0MEU6 151 6,64490
A0A2U8USG0 167 9,21706
A0A2D2W691 151 9,29784
A0A2H1X8W0 151 7,05135
A0A1V0E6I4 151 8,80814
A0A2K9VHF1 143 9,11681
A0A0G2T5U2 146 9,43625
A0A0U3E5Q4 151 9,03075
A0A219YHA3 151 8,46884
A0A249Y244 151 8,80852
A0A2S1PDT1 153 8,82567
A0A2S1PGS0 153 8,84430
A0A2U7NLZ5 153 7,80707
A0A2Z4Q2C1 151 8,44537
A0A3Q9WSD5 167 9,34755
A0A482MGI9 152 8,46903
A0A4Y5TVN2 151 9,03075
A0A514U6B0 167 9,21706
A0A5B9N630 148 7,79276
A0A5B9NED3 148 8,45459
A0A5B9NFG4 152 8,82561
A0A5B9NGH2 151 8,46736
A0A5B9NH18 151 8,94571
A0A5B9NLM4 151 8,36685
A0A5C2ID58 151 7,77241
A0A5J6CUK2 151 8,80794
A0A5J6DA40 151 9,05157
A0A5J6T826 152 9,21829
A0A5P8D2R5 152 8,48077
A0A5P8NK62 149 8,70666
A0A5P8PKH0 151 8,82587
A0A5Q2W9T8 151 8,82542
A0A678ZXM7 126 7,84769
A0A6G6AGP7 152 8,46742
A0A6M2Z6W9 151 7,77241
A0A6M3T8S4 143 9,13699
A0A6M3TA27 146 9,11707
A0A6M5CBU9 152 9,27018
A0A6M9QBN7 148 9,58137
A0A7D0PL93 146 9,43625
A0A7D0PLK5 146 9,43625
A0A7D0TNR2 146 9,43625
A0A7D3UHM3 151 7,05164
A0A7D3UN36 151 8,80852
A0A7D5FUT4 150 9,32621
A0A7D5JFP5 152 8,84392
A0A7D5JNP6 152 9,21829
A0A7G3WWN7 151 7,79096
A0A7G5BCT8 151 7,09029
A0A7G7YB61 152 8,46755
A0A7G8LJ63 152 8,70705
A0A7G8LJN4 146 9,27038
A0A7G8LJT5 146 8,88531
A0A7G9IRD1 111 8,95764
A0A7G9UT90 151 8,46736
A0A7I6HJW2 153 7,78677
A0A7L7SMW6 151 9,05157
A0A7L7SN26 151 8,36692
A0A7L7SN88 151 9,05157
A0A7L7SNE4 151 9,05157
A0A7L7SXL3 151 9,05157
A0A7S6R7U6 151 8,80852
A0A7S6R7Z4 151 8,80794
A0A7S6R8B3 151 8,80852
A0A7S6R8K3 151 8,80852
A0A7S6R8Q6 151 8,80852
A0A7S6R8U8 151 8,46736
A0A7S6R971 151 8,80852
A0A7S6R9H1 151 8,80852
A0A7S6R9M3 151 8,80852
A0A7S6R9T0 151 9,05157
A0A7S6R9U6 151 8,80852
A0A7S6R9W2 151 8,80852
A0A7S6R9X0 151 8,80852
A0A7S6R9Y5 151 8,80852
A0A7S6RAC9 151 8,46897
A0A7S6U0I2 151 8,80852
A0A7S6U2E2 151 8,80852
A0A7S6U2H7 151 8,80852
A0A7S6U309 151 8,80794
A0A7S6U3D3 151 8,80852
A0A7S6U3Z5 151 8,80852
A0A7T6ZMJ8 153 8,74664
A0A7T7K7I5 206 9,29926
A0A1V0E6C8 151 8,46736
A0A2U8UST6 151 8,46736
A0A3G8F372 151 8,46736
A0A4P6DAH4 151 8,46736
A0A5B9NBX3 167 9,21706
A0A5B9NDA7 167 9,21706
A0A6G5Y7B4 153 7,09307
A0A7G8L157 152 8,48077
A0A7S6R7K4 151 8,46736
A0A7S6R7S8 151 8,46736
A0A7S6R989 151 8,46736
A0A886T189 152 8,82561
A0A8F2F3Z2 152 8,79151
A0A8T8JEC6 152 8,79151
A0A977KCZ7 151 8,46736
A0A9E6YHL3 152 8,80807
A0A9E7LUW5 151 8,72053
A0A9E7M8R5 152 8,46736
A0A9E7NN46 149 8,70666
A0A9E7QN49 151 7,00878
A0A9E7SZP8 152 8,82542
A0A9E7T687 151 7,00878
A0A9E8G557 151 8,46736
A0A9E8JZN1 151 8,46736
A0A9E9BWP0 151 7,76753
A0A9E9P758 151 8,82587
A0A9E9P8T6 151 8,82587
A0A9X9IAQ2 151 7,79308
A0A9X9JP98 151 8,80814
A0A9X9JPJ5 151 8,80814
A0A9X9JPJ8 151 8,46736
A0A9X9JQZ7 151 8,46736
A0A9X9NYV0 151 8,80814
A0A9X9NZ77 151 8,80814
A0A9Y1YYH8 151 8,46897
A0AA47LWD4 152 8,80814
A0AA49X5J7 154 9,03036
A0AA50AEB9 151 7,77310
A0AA50F0V6 155 8,46742
A0AA51N0G3 152 8,46897
A0AA51N3Y8 151 7,77213
A0AA51VHB5 304 9,05492
A0AA96K522 151 8,46736
A0AA96KHF7 152 8,46749
A0AA96KQK7 151 8,46736
A0AAD2GP72 151 8,80814
A0AAD2GQ22 151 8,80814
A0AAE7T1M8 152 8,46736
A0AAE7TQ68 151 6,70054
A0AAE7VFD9 151 7,00924
A0AAE7VK86 146 9,27031
A0AAE7VQ21 151 7,09086
A0AAE7XXQ6 152 8,46736
A0AAE8AZB1 151 7,09086
A0AAE8C2T1 152 8,46736
A0AAE8C429 152 8,46736
A0AAE8C452 152 8,46736
A0AAE8C5I9 152 8,46736
A0AAE8C6U4 152 8,46736
A0AAE8C711 152 8,46736
A0AAE8XPL6 152 8,48077
A0AAE8Y7X6 152 8,46910
A0AAE8YE12 151 8,46736
A0AAE8YEK7 151 8,80852
A0AAE8YH34 151 8,48373
A0AAE8YH97 151 7,79083
A0AAE8Z1V3 152 8,46749
A0AAE8Z4X3 152 8,46749
A0AAE9BNS7 146 9,27031
A0AAE9BQI3 152 8,46749
A0AAE9C758 152 8,46749
A0AAE9CAX4 153 9,29952
A0AAE9HPI2 151 8,46736
A0AAE9KEN2 152 8,46749
A0AAE9NMP1 151 7,09029
A0AAE9VVA9 152 8,80807
A0AAE9VXH1 152 8,80807
A0AAE9VZ49 152 8,82561
A0AAF0D780 151 8,46736
A0AAF0D7J0 151 8,46736
A0AAF0D7K3 151 8,46736
A0AAF0D9U8 151 8,80814
A0AAF0ID16 151 8,82587
A0AAF0KD08 151 7,79618
A0AAF1K1S0 152 8,48083
A0AAT9S7P0 151 7,09029
A0AAU6VZA4 146 9,13738
A0AAU7VFF5 152 8,82580
A0AAU7VHJ2 151 7,05209
A0AAU8BCN1 152 8,80872
A0AAU8GDQ9 152 8,80814
A0AAU8GG16 152 8,80814
A0AAU8GH25 152 8,80814
A0AAV1MAE1 151 9,05118
A0AAV1MAT9 151 8,46736
A0AAV1ME20 151 9,03075
A0AAV1MEI4 151 7,08989
A0AAV1MEJ4 151 9,07330
A0AAV1MER1 151 8,46736
A0AAV1MEZ4 151 8,46736
A0AAV1MF57 151 7,77298
A0AAV1MGM0 151 8,80814
A0AAV1MJ20 151 8,46891
A0AAV1MJ66 151 8,80794
A0AAV1MJ85 151 8,80794
A0AAX3BPH0 151 8,84372
A0AAX4B116 151 8,46736
A0AAX4FD64 151 9,12229
A0AAX4G450 151 8,46736
A0AAX4G4N1 152 8,46749
A0AAX4G538 152 8,46749
A0AAX4G5B4 151 8,46736
A0AAX4M7Y1 166 9,37404
A0AAX4MUM0 151 9,07330
A0AAX4MWC9 146 9,60220
A0AAX4N7J3 146 9,43625
A0AAX4NCZ4 146 9,27031
A0AAX4Q0L6 146 9,51265
A0AAX4Q2C8 151 8,46884
A0AAX4Q375 151 8,82529
A0AAX4Q4W4 151 8,82587
A0AB39C2W8 151 8,82587
A0A6G5YCG4 151 8,80820
A0AB74UQM0 146 9,27031
A0A6J5QZ36 144 9,80940
A0A9E7NM18 149 9,34787
A0A9E8RTZ7 153 8,80846
A0AAE7VMV3 205 9,40151
A0AAE9KT25 153 8,72065
A0AAF0CXH3 148 7,79831
A0AAF0K2B9 146 9,26928
A0AAU6W2T0 146 9,11707
A0AAU6W348 146 9,24291
A0AAU8BTJ5 146 9,40454
A0AAU8BUA5 151 8,46749
A0AAU8EC81 151 8,80814
A0AAU8EDP8 151 8,46736
A0AAU8EDV6 151 8,82542
A0AAU8EEL1 151 8,46736
A0AAU8EF92 151 8,46736
A0AAX4GAG1 151 8,82587
A0AAX4GFL5 151 9,03075
A0AAX4GLG4 151 8,46736
A0AAX4GP12 151 8,82542
A0AAX4GSJ5 151 8,79151
A0AAX4GTI0 151 9,05157
A0AAX4GWI8 151 8,79151
A0AAX4H1W0 151 8,46884
A0AAX4J5T9 151 5,74480
A0AAX4N2H8 153 7,79283
A0AAX4NB54 146 9,58195
A0AAX4NBY9 146 9,07381
A0AAX4NDQ7 146 9,24291
A0AAX4NDX1 146 9,07381
A0AB38ZD00 119 8,50675
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_5171
285Oe
 13 51,8% 162 1.120E-61
2 phalp2_25557
3CTPR
 25 37,0% 240 4.317E-50
3 phalp2_9794
8qYns
 5 42,2% 154 4.751E-48
4 phalp2_28171
8yYQh
 287 39,6% 169 3.413E-45
5 phalp2_25618
48uUY
 31 36,6% 183 3.538E-32
6 phalp2_2920
NQqI
 114 33,7% 169 3.745E-30
7 phalp2_14613
5sQyS
 2 30,5% 154 5.108E-30
8 phalp2_30941
13o5z
 7 30,8% 149 4.209E-24
9 phalp2_18287
4ZlaN
 11 31,7% 164 3.150E-20
10 phalp2_20811
63TES
 2 28,4% 172 2.092E-11

Domains

Domains [InterPro]
Ami2
Unannotated
Disordered region
Representative sequence (used for alignment): 4CbZx (239 AA)
Member sequence: A0AAU6PXR5 (151 AA)
1 239 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage ETEP21B
[NCBI] 		3117681 Autographiviridae > Berlinvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR979722 [NCBI]
CDS location
range 9639 -> 10094
strand +
CDS
ATGAGTAAGGTACAATTCAAACCACGCGCTGTGACAGAAGCAATCTTTGTCCACTGTAGCGCAACTAAGGCGACCATGAACGTTGGTCTGCGTGAAATCCGTCAGTGGCATAAAGAACAGGGCTGGCTTGATGTAGGCTACCACTTCATTATTCGCCGTGATGGTACAATCGAAGAAGGCCGTCCGGTCGATGTCGTTGGGTCTCATGTGAAAGACTGGAACAGTAAGTCAGTCGGTGTGTGTCTCGTTGGTGGTATCGACGAAAAGGGCAAACACGAAGCTAACTTTACTCCAGCACAGATGCAGTCTCTTAAAGAGAAACTGGCAGACCTGAAAGACCTGTACCCGGATGCTGAAATCAAAGCGCACCACGATGTCGCACCTAAAGCATGTCCAAGTTTTAACTTGAGTCGCTGGCTGAAGACTGGTGAATTAGTAACAAGTGATTGGGGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0032897 negative regulation of viral transcription biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04111

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4CbZx) rather than this protein.
PDB ID
4CbZx
Method AlphaFoldv2
Resolution 79.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50