Protein

Protein accession
A0AAT9S6R2 [UniProt]
Representative
7Z48s
Source
UniProt (cluster: phalp2_28564)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTRVQFKQRESTDAIFVHCSATKPSQNVGVREIRQWHKEQGWLDVGYHFIIKRDGTVEEGRDEMAVGSHVKGHNHNSIGVCLVGGIDDKGKFEANFTPAQMKSLRSLLVTLLAKYEGAVLKAHHDVAPKACPSFDLKRWWETNQLVTSDRG
Physico‐chemical
properties
protein length:151 AA
molecular weight:17013,1 Da
isoelectric point:8,81
hydropathy:-0,51
Representative Protein Details
Accession
7Z48s
Protein name
7Z48s
Sequence length
201 AA
Molecular weight
22305,02020 Da
Isoelectric point
6,65644
Sequence
MRDVNRIFIHHSATTVDQTVNVEVLDQWHRARGFSGIGYHYVILRDGTVEKGRPELKVGAHVKNHNTGSLGICLVGGLNAQKKAENNFTDSQFNALRKLLKSLIDKYGEVEVLGHKEVAQTECPPFDVQAWLADNLAKTDAPSVKMSVEITPQIETQLKGIENGLANIRTLWSSSWSSSLQLELGGLEDCTKNLRSLLKND
Other Proteins in cluster: phalp2_28564
Total (incl. this protein): 97 Avg length: 141,1 Avg pI: 7,93
Protein ID Length (AA) pI
7Z48s 201 6,65644
T1PTT1 151 9,03055
A0A2H4P6C3 151 8,82606
Q2WC97 117 7,84717
A0A088FBW1 151 8,45749
A0A1I9SE91 152 7,77819
Q9T132 151 9,03055
A9XKX5 96 6,83304
E1XU94 151 8,46878
A0A289YLY8 151 9,03055
Q6WY45 151 8,80820
B3FYI8 151 8,79176
A0A385IPD3 151 8,79176
A0A6B9RJP7 151 8,82606
A0A3Q9I5D4 152 8,82542
A0A2K9VJV1 151 8,82606
A0A0E3M152 151 8,80833
A0A0U2DV48 151 8,79176
A0A172JFY8 151 9,03055
A0A193GYQ9 151 9,03055
A0A1P8EDQ7 151 8,79176
A0A2I7QJ07 150 6,28840
A0A2I7QQD0 150 6,28840
A0A2I7QSV6 150 6,28840
A0A2I7QU52 139 8,58946
A0A2I7QUC7 150 6,28840
A0A2I7QUR2 150 6,28840
A0A2I7QVC5 150 6,28840
A0A2I7QYJ6 139 8,58946
A0A2I7R364 139 8,58946
A0A2I7R4R2 139 8,66831
A0A2I7R7R6 139 8,58946
A0A2I7R7X8 139 8,66831
A0A2I7R8A8 139 6,57698
A0A2I7RA72 139 7,69636
A0A2I7RDH9 139 7,69636
A0A2I7RE63 139 8,58953
A0A2I7RFJ8 139 8,66831
A0A2I7RHD8 139 8,66831
A0A2I7RJM8 139 8,26216
A0A2I7RJV0 139 8,26216
A0A2I7RK30 139 8,26216
A0A2I7RV52 139 8,81510
A0A2I7S0Q5 139 8,66831
A0A2I7S7M5 150 6,28732
A0A481V9B6 151 8,82606
A0A482MGV6 151 9,03055
A0A6B9RKM3 151 8,79221
A0A7G9UTJ9 151 9,03030
A9XKW3 96 6,83304
A9XKW5 96 6,36821
A9XKW7 96 6,15330
A9XKW9 96 8,00815
A9XKX1 96 6,36821
A9XKX3 96 7,77626
A9XKX7 96 6,36821
A9XKX9 96 7,77626
A9XKY1 96 6,36821
A9XKY3 96 6,36821
A9XKY5 96 7,77606
A9XKY6 96 6,83895
A9XKY7 96 7,77606
Q3YJY6 152 8,49463
Q6WYQ4 151 8,80820
A0A8T8IY39 151 8,80820
A0A8X8M5P2 151 9,03055
A0A8X8M6J2 151 9,03055
A0A8X8RI72 151 8,92927
A0A976X745 151 8,79176
A0A9E7NX54 151 8,79176
A0A9E7T0V3 151 9,05086
A0A9E9ETP9 151 9,03055
A0AA51N006 151 8,45756
A0AAE7RMK0 152 8,42210
A0AAE7VK96 151 8,36685
A0AAE7VVL0 151 7,78264
A0AAE9BPH7 151 7,80185
A0AAE9GPN7 152 8,46749
A0AAF0BYS8 151 9,03055
A0AAF0D622 151 8,79163
A0AAT9S708 151 8,80878
A0AAT9S943 151 8,80859
A0AAV1MJE3 151 8,79176
A0AAX3BPL4 151 9,03055
A0AAX4RE00 151 9,03055
A0AAX4N3B6 164 5,68654
A0AAX4N3R2 164 5,68654
A0AAX4N408 164 5,92367
A0AAX4N479 164 5,68654
A0AAX4N4R6 164 5,92367
A0AAX4N654 164 5,92367
A0AAX4N671 164 5,68654
A0AAX4N680 164 5,92367
A0AAX4N8N2 164 6,18541
H6BFH3 75 7,78258
H6BFK6 107 7,97721
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24237
2YSsA
 71 47,5% 145 1.191E-65
2 phalp2_35819
4CbZx
 312 42,5% 160 1.479E-64
3 phalp2_3887
6RreM
 7260 52,5% 137 1.143E-55
4 phalp2_11894
2jrH4
 329 49,2% 142 2.145E-55
5 phalp2_36193
72BPm
 409 51,4% 134 4.084E-52
6 phalp2_28171
8yYQh
 287 48,3% 153 1.070E-45
7 phalp2_23766
13ajC
 287 44,2% 131 4.645E-44
8 phalp2_11611
1k5JO
 2203 36,5% 145 3.045E-37
9 phalp2_12261
71VXz
 7 39,0% 151 1.068E-36
10 phalp2_23565
7vNZv
 154 43,4% 138 1.999E-36

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7Z48s (201 AA)
Member sequence: A0AAT9S6R2 (151 AA)
1 201 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Yersinia phage vB_YenP_WX2
[NCBI] 		2973500 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP219460 [NCBI]
CDS location
range 648 -> 1103
strand +
CDS
ATGACTCGTGTACAGTTTAAACAACGTGAATCTACTGACGCAATTTTTGTTCACTGCTCGGCTACCAAGCCAAGTCAGAATGTAGGTGTCCGTGAGATTCGTCAGTGGCATAAAGAGCAAGGTTGGCTTGATGTCGGGTATCATTTTATCATCAAGCGCGATGGCACTGTAGAGGAAGGTCGCGACGAGATGGCTGTGGGTTCACACGTTAAGGGTCACAACCATAACTCAATCGGTGTCTGCCTTGTTGGTGGTATTGACGATAAAGGTAAGTTCGAAGCTAACTTTACACCAGCCCAAATGAAATCCCTTCGCTCACTGCTTGTCACACTACTGGCTAAGTACGAAGGCGCTGTACTGAAAGCCCATCACGATGTAGCACCCAAGGCTTGCCCTTCGTTCGACCTTAAGCGTTGGTGGGAAACTAATCAATTAGTAACATCTGATCGTGGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0032897 negative regulation of viral transcription biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04111

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7Z48s) rather than this protein.
PDB ID
7Z48s
Method AlphaFoldv2
Resolution 89.68
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50