Protein

Protein accession
A0AAF0K542 [UniProt]
Representative
5EHHM
Source
UniProt (cluster: phalp2_30561)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
VAL
Probability: 99% (predicted by ML model)
Protein sequence
MRLENNLGGDNLYGNFRLYIEGIEVPFSSASITNTYRGLPTAQIVLAPWRGFSEISKGYFPKVHLFYRDFNQGLAPYDMKKMVGGVATMNTLEAQSAMAEAAETFNKLERHAYKLIFGGVVTSVTDSKSLAGEGGSASLVLSCVHPYYLLNEILFKYIGTNPQETTARDSAFGIMVDGGNVGSLYTIEQALAGVRAPGDGQVTLEDGGKDTSVLSDTMADNYWRLQGIPGVIVALWNSFKRSAYSTDSQKNKTIMTKMYIPLLESGLKYFSKMTGHPVIEGAIQKDSKTPPTQAPATTQTAATGSSPKAVPGLTTMSSRGKKELIEFSEGRHYKLYDDATGKTIAHALDATGTPTIGVGHAVDKTDTQFDGKTLSDAQVDNLLADDISNSERAVAKLGLTLSQGQFDALVDLTFNVGPGGPGRDGALRQSNGQPSTLVRLITEGNTQGAANEFMSWVYSGNKVSQGLVNRRKRDQAFFLDAPLPSAQSLAANAYSSRGSNEEMATNNGKLIPGNMNGMLPRAIAEQLLHILSGHMTSGGTGEVMSFGQLIDAFLEVVEYDHIIMNSPAKVGISGQPELIDHVYKPKMFAYYAPICNVLLPYMYESYSVNIGTDQVPSRVIYNGMPFTADSAANSGTTVNMHNYVAPHSVRVALADGGNLAQTLISLVASPGKYEWGSGVRTADGTLPYWYAVLSHQAASGNVGDLANGTTLENLKAAWNKLYPEDPTLNPWDTDLSGIDAYQRLFFTGVDVEFSNAYSQARQGSVDGVFNPFIIPGYPMDVVDPSPLRESYHGFCTSVTHNIDATGHASTSIGMSSAYTFSEIATCYIPGTYPWLLAQLKMDENLKMYGNTPAYQRACQYYNDVLGVGAADPTILEAYSTGRPIPVKRNMGVWEIGEADTLTGSTHPTLYNTTLGNLNLVARNIASLLDIEKEHAMVTETFVDIDMWNQGSPTVEEVRKGPWVNDQSGTQDSSTLRGRDMECSAFLDYDSEAETPDPIIVPGYRETNVPPTVGQPGLPLQQATVQGQKADVLPKLGKRCSVGALDATSQAKLAECHPDLVKVVMKVIETRPVVITSGYRTSAKQAALENGGGKYAQGAGKGSRHLKYPSWAVDMVPCNNLNASSRAVMQNFAEYVLSVANSMGISLRWGGNFSTYDPVHFDLGLG
Physico‐chemical
properties
protein length:1165 AA
molecular weight:125662,0 Da
isoelectric point:5,38
hydropathy:-0,24
Representative Protein Details
Accession
5EHHM
Protein name
5EHHM
Sequence length
232 AA
Molecular weight
24548,44270 Da
Isoelectric point
7,87721
Sequence
MRTSQQGRDRIKKHEALRLVSYRDAVGVWTIGWGNTGSEYAREGVRISKSKAQALFDGDIAEAEAIVDKAVSVPLSQEQYDALVSFVFNIGPGSKHKDGFVRLKNGKPSTLLRLLNEGKYEAAAQQFNRWVYGGGRILGGLVKRRAEETALFLEGTTSEVTTTSDTGPESGVIGESAPKGNEAPAAAALGGVAAVAAPLLQAASGATPALVATIFAALAAAYLIWKLTKEDE
Other Proteins in cluster: phalp2_30561
Total (incl. this protein): 5 Avg length: 395,2 Avg pI: 8,43
Protein ID Length (AA) pI
5EHHM 232 7,87721
6PRH1 255 9,93079
A0A6G5Y6V0 160 9,51716
A0A8K1BE17 164 9,45714
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33221
5jbqV
 447 49,3% 154 1.274E-47
2 phalp2_10966
4MkR6
 70 42,5% 160 5.476E-46
3 phalp2_28113
7zmZV
 50 45,2% 157 7.492E-46
4 phalp2_2632
6RhYr
 14867 46,0% 152 4.909E-45
5 phalp2_2498
5GMvl
 297 45,6% 162 6.015E-44
6 phalp2_2176
3Yhf4
 930 42,2% 168 3.937E-43
7 phalp2_6830
8n5Jv
 121 46,8% 158 5.384E-43
8 phalp2_8252
7B99h
 46 45,3% 152 7.363E-43
9 phalp2_14481
4Lj5N
 23 38,8% 211 1.883E-42
10 phalp2_4532
3QBcV
 9 47,3% 150 3.522E-42

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 5EHHM (232 AA)
Member sequence: A0AAF0K542 (1165 AA)
1 232 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Salmonella phage Arash
[NCBI] 		3038319 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ632216 [NCBI]
CDS location
range 8089 -> 11586
strand +
CDS
ATGCGTTTAGAAAATAATCTCGGCGGGGACAACCTCTACGGGAACTTCCGGCTGTACATCGAGGGGATCGAGGTCCCCTTCTCTTCAGCGAGCATCACGAATACATACCGCGGACTGCCGACGGCTCAGATCGTCTTGGCACCGTGGCGGGGGTTCTCGGAGATCTCTAAGGGGTACTTCCCGAAGGTTCACCTCTTCTACCGTGACTTCAACCAAGGCTTAGCGCCTTATGACATGAAGAAGATGGTCGGCGGTGTAGCCACTATGAATACGTTAGAGGCTCAATCGGCGATGGCAGAGGCCGCTGAGACCTTCAACAAGCTCGAACGTCACGCCTACAAGCTGATCTTCGGCGGTGTCGTCACATCCGTTACCGACTCGAAGTCATTAGCCGGCGAGGGTGGTTCAGCGAGCTTAGTGCTCTCCTGCGTTCACCCGTATTACCTGCTGAACGAAATCCTCTTCAAGTACATCGGTACCAACCCTCAGGAAACGACGGCCCGGGACTCAGCCTTCGGTATCATGGTGGACGGCGGTAACGTCGGCTCTCTGTATACCATCGAGCAGGCGCTGGCGGGTGTACGTGCCCCTGGCGACGGGCAGGTGACGCTGGAAGACGGTGGCAAGGACACGTCCGTGCTGTCCGATACGATGGCGGATAACTATTGGCGTCTTCAGGGTATCCCAGGGGTGATCGTGGCCCTCTGGAACTCCTTCAAGCGTTCGGCGTACTCTACCGATTCGCAGAAGAACAAGACGATCATGACGAAGATGTACATCCCGCTGCTGGAAAGCGGCTTGAAGTACTTTAGCAAAATGACCGGGCACCCGGTGATCGAAGGCGCTATCCAGAAGGATTCCAAGACGCCTCCGACCCAGGCGCCAGCGACGACCCAGACCGCGGCAACGGGCTCCTCCCCGAAAGCCGTCCCCGGTCTGACAACCATGTCGTCCCGTGGCAAGAAGGAGTTGATTGAGTTTTCTGAAGGCCGTCACTACAAGCTGTACGATGACGCCACCGGTAAGACAATCGCTCACGCACTCGATGCCACCGGCACCCCGACAATTGGGGTTGGCCATGCGGTAGACAAGACAGATACCCAGTTCGATGGCAAGACACTCTCTGACGCTCAGGTTGACAACCTGTTGGCCGATGACATCTCTAACTCTGAGCGTGCCGTAGCCAAGCTCGGCCTCACCCTCTCTCAGGGCCAGTTCGATGCACTGGTGGATCTGACCTTCAACGTCGGTCCAGGCGGTCCAGGTAGAGATGGAGCTCTTCGTCAGTCTAACGGGCAGCCATCGACTCTCGTTCGCTTGATCACTGAGGGGAATACTCAAGGTGCTGCGAATGAGTTCATGTCATGGGTATACTCTGGAAATAAAGTCTCCCAGGGTCTGGTGAATCGCCGTAAGCGTGACCAAGCGTTCTTCTTAGATGCTCCGCTTCCGTCGGCTCAGAGTCTGGCTGCGAATGCCTACTCTTCCCGCGGTTCCAACGAGGAAATGGCCACAAACAACGGTAAGCTGATTCCGGGGAATATGAATGGTATGCTCCCACGTGCGATAGCTGAACAGCTGCTGCACATCCTGAGTGGCCACATGACCTCAGGTGGGACCGGTGAAGTGATGTCTTTCGGCCAACTGATCGATGCCTTCTTGGAAGTCGTTGAGTATGACCATATCATCATGAACTCACCGGCTAAGGTGGGGATTTCCGGACAGCCGGAACTGATCGATCACGTCTACAAGCCGAAGATGTTCGCGTACTACGCCCCGATCTGTAACGTACTGCTTCCGTACATGTACGAATCCTACTCGGTGAACATCGGGACCGATCAGGTGCCTTCACGTGTGATCTACAACGGGATGCCTTTCACGGCTGACTCCGCGGCTAACTCCGGTACGACCGTGAACATGCACAACTACGTCGCCCCTCACTCTGTCCGTGTGGCGCTGGCTGACGGCGGTAACCTAGCCCAGACCCTTATCTCTCTGGTCGCGTCGCCTGGGAAGTACGAGTGGGGTTCCGGTGTGCGTACGGCGGACGGTACTCTGCCTTACTGGTATGCCGTGCTGTCGCATCAAGCAGCCTCCGGTAATGTTGGTGACTTAGCGAATGGCACAACGCTCGAGAACCTGAAGGCTGCGTGGAATAAACTGTATCCGGAGGACCCGACGCTGAACCCGTGGGACACCGATCTGTCAGGGATTGATGCCTACCAGCGTCTGTTCTTCACCGGTGTCGACGTGGAGTTCTCGAATGCGTACTCACAGGCCCGCCAGGGAAGCGTAGACGGCGTTTTCAACCCGTTTATCATCCCAGGGTACCCAATGGACGTCGTCGATCCAAGTCCTCTCAGAGAGTCCTACCACGGCTTCTGTACGAGTGTGACTCACAACATTGACGCGACGGGGCACGCTTCGACGTCGATCGGTATGTCCTCAGCATACACCTTCTCGGAGATCGCGACGTGCTACATTCCGGGAACCTACCCATGGCTCCTCGCTCAGCTGAAGATGGACGAGAACCTGAAGATGTACGGGAATACGCCGGCCTATCAGCGTGCCTGCCAGTACTACAATGACGTGCTCGGTGTGGGTGCAGCGGATCCGACGATCCTCGAAGCGTACTCTACCGGTCGTCCTATTCCGGTGAAGCGTAACATGGGTGTCTGGGAGATCGGCGAAGCGGATACACTGACAGGATCAACCCACCCGACGCTATACAACACGACGCTCGGTAACCTGAACCTCGTGGCCCGTAACATCGCGTCACTGCTGGATATCGAGAAGGAACACGCCATGGTAACAGAGACATTCGTGGATATCGACATGTGGAACCAAGGTTCTCCGACCGTTGAAGAGGTCCGTAAGGGTCCGTGGGTGAATGATCAGTCTGGAACGCAGGATTCTTCTACGCTCCGCGGTCGTGATATGGAGTGCTCAGCCTTCCTGGATTATGACTCAGAGGCCGAAACGCCAGACCCGATCATTGTCCCGGGTTACCGTGAGACAAACGTGCCGCCGACGGTAGGTCAACCTGGTCTGCCGCTGCAACAAGCAACCGTACAGGGTCAGAAAGCAGATGTTCTGCCTAAACTCGGTAAGCGTTGTTCAGTTGGTGCCCTGGATGCGACCTCTCAGGCGAAGTTGGCCGAGTGTCACCCAGATCTGGTTAAGGTCGTGATGAAAGTCATCGAGACCCGTCCAGTGGTCATCACCTCCGGCTACCGTACGTCTGCTAAGCAGGCGGCCCTGGAGAATGGTGGTGGTAAATATGCTCAAGGTGCAGGCAAAGGTTCTCGTCACCTCAAATATCCATCATGGGCAGTCGACATGGTACCGTGTAACAACCTGAACGCGTCTTCACGTGCAGTAATGCAGAACTTCGCGGAGTACGTTCTGAGCGTGGCGAACTCAATGGGCATCAGTCTGCGTTGGGGTGGGAACTTCTCAACGTATGATCCAGTGCACTTCGACTTAGGACTCGGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5EHHM) rather than this protein.
PDB ID
5EHHM
Method AlphaFoldv2
Resolution 79.47
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50