Protein

Protein accession
A0AAE9W3D8 [UniProt]
Representative
7dmzX
Source
UniProt (cluster: phalp2_35318)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MATWKWCLAKEDGTVVKGWYEDNGKWYYLKDNGTMAENEWIKDKDERWYYLGNKGEMKTGWFQSPISNKWYYLEPSSNGYKGAMYTQGTYIIDGKEQKFDSDGAWIEDTFVSDKLIDFVKSWEGFYPNKYYDCVGVLTQGYGLTGSEIENLPDRITEKEASDLLKKVINDKYAKIVKNDLDSKGIKLSQNEFDSLVSFAYNCGTSGLLGSTLYKNVVAGVRDSNIITANFQAWSNGGGNRIEGLYRRRTKEAAMFLKSDYTGNV
Physico‐chemical
properties
protein length:264 AA
molecular weight:30176,4 Da
isoelectric point:5,33
hydropathy:-0,66
Representative Protein Details
Accession
7dmzX
Protein name
7dmzX
Sequence length
271 AA
Molecular weight
31334,69730 Da
Isoelectric point
5,30373
Sequence
MSNWKWCVEDSTGNITKGWYKDNEKWYYLKDNGTMATGWNEDKDGRWYYLDENGAMQTGWLKDKEKWYYLEPNSTGYKGEMYGNRTAIIDGKLYYFNGTGAWIEEDFLMSYKCVEFVGSWEGFYSKAYEDPYYTGNKKWWTIGYGTTYAVIPEAFPKGLDSTCTKEQALVWLRHEMETCAKAIKGNLDSKGIVLKQNEFDSLVSFAYNCGTGALFGSTLYKNICNGIRNKDVITSNFAMWCNANGQQSEGLYRRRTKEADMFLNADYTGNL
Other Proteins in cluster: phalp2_35318
Total (incl. this protein): 68 Avg length: 266,1 Avg pI: 5,82
Protein ID Length (AA) pI
7dmzX 271 5,30373
1NfrR 254 9,26322
1NfyG 294 7,59235
2av1r 254 9,20281
2k9vo 262 4,85799
2mvsP 276 4,57181
3AXAJ 257 4,81627
3Bm8h 242 4,83117
3Fwj7 267 4,59682
3GKW6 232 4,75506
3IaZ2 339 4,56664
3P6ka 266 4,66872
3PdA4 232 4,59881
3PdXp 371 4,65900
3SXSv 270 4,64599
3xQ6z 252 8,76282
4lNg6 279 5,32578
5O98y 263 9,06627
5PdKq 259 5,68659
5hSWr 251 9,20249
5hWJy 259 4,61467
5hXPs 257 5,18073
5i0ww 264 5,03061
5i29i 268 4,89193
5iqPZ 254 7,54693
5iqsy 254 5,27468
6HRym 284 9,08767
737Us 264 5,53785
75zyU 261 4,90665
75zzC 263 6,62461
7BFD6 260 5,40876
7BFE0 261 5,16225
7BFGx 260 7,49265
7BFHy 263 6,05105
7BFIO 261 7,49311
7BkiV 263 6,61756
7Bkk2 266 4,94678
7bd5E 268 5,43582
7bdiT 261 6,05258
7bdjT 268 5,43582
7creO 262 4,69515
7dfeG 261 8,37465
7dffE 261 5,18863
7dmxz 261 8,33713
7f607 263 6,73749
7f61D 260 5,30134
7gDy5 260 4,76609
7hCgD 263 5,60833
7jhE0 284 4,36480
7jjG3 232 4,80315
7jjJl 267 4,44193
7kZQE 297 4,80803
7kkFr 261 6,62444
7llDN 262 6,62654
7llG4 263 5,35352
7llKA 263 6,63166
7llKi 261 5,44526
7llPy 260 5,18289
7llQe 263 5,34215
7llvZ 266 6,59437
7mjSS 298 4,81872
7ol0X 275 4,57067
7tsK3 264 4,73596
7vdA3 262 5,35380
8pGCl 294 5,66170
8pmeN 255 5,44918
wePQ 264 4,64513
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3550
4CbTI
 96 30,2% 208 1.315E-31

Domains

Domains [InterPro]
Choline_bind_3
GH24
Representative sequence (used for alignment): 7dmzX (271 AA)
Member sequence: A0AAE9W3D8 (264 AA)
1 271 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF19127

Taxonomy

  Name Taxonomy ID Lineage
Phage Clostridium phage CB452P1
[NCBI] 		2968621 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP172752 [NCBI]
CDS location
range 18624 -> 19418
strand +
CDS
ATGGCCACATGGAAATGGTGTCTTGCAAAAGAAGATGGTACTGTTGTAAAAGGTTGGTATGAAGATAATGGTAAGTGGTACTATTTAAAAGATAATGGTACTATGGCAGAAAATGAATGGATAAAAGATAAAGACGAAAGATGGTACTATTTAGGCAATAAAGGAGAAATGAAAACAGGATGGTTTCAATCACCTATTAGTAATAAATGGTACTATTTAGAGCCTTCTAGCAATGGATACAAGGGTGCTATGTATACTCAAGGAACTTATATAATAGATGGTAAAGAACAGAAATTTGATTCTGATGGTGCTTGGATTGAAGATACATTTGTGAGTGATAAACTTATTGATTTTGTTAAATCATGGGAAGGTTTTTATCCTAATAAATATTATGATTGTGTAGGAGTTTTAACTCAAGGATACGGACTTACTGGATCTGAAATAGAAAATTTGCCAGATAGAATAACCGAAAAAGAAGCAAGTGATTTACTAAAGAAAGTTATAAATGATAAATATGCTAAAATAGTAAAAAATGATTTAGATTCTAAAGGTATAAAATTATCTCAAAACGAATTTGATTCACTTGTAAGCTTTGCATATAATTGTGGAACTTCTGGACTTTTAGGAAGTACATTATATAAAAATGTAGTTGCTGGAGTAAGAGATTCTAACATAATTACAGCTAATTTCCAAGCATGGAGCAATGGTGGAGGAAACAGAATAGAAGGACTTTACAGGCGAAGAACAAAAGAAGCTGCAATGTTTCTAAAATCAGACTATACAGGCAATGTATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7dmzX) rather than this protein.
PDB ID
7dmzX
Method AlphaFoldv2
Resolution 93.12
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50