Protein

Protein accession
A0A8S5TYG6 [UniProt]
Representative
3u8Hb
Source
UniProt (cluster: phalp2_23979)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MKEGGVDERMKISEKGLSMIERFEGCLLKASNKLDGVWTIGYGQTGSYYGKRVRRGMTTTKALAHAWLRDHSIKTYEDAVTQAVKVPLNQNQFDALVSFAYNVGVGALKQSTTLRKLNAGDYAGAADALTMWTKCKGKVLAGLVRRRKEERALFLTPVTQAKTTNTDLLRKGDRGDDVKLLQHRLNILGWQLTEDGIWGVKTDTAVRNYQYHADLTVDGIVGPKTQAALIKDAILARAAEMGAYMVKHKWHYQDKTYRAKSTFAATKALDKPGSSCSHYVSWVLQDVGLLESGKRISHDNGKVTGTGNLIGCQVIQAGGKTWDKLSDLRPGDVCVWDSNLAIYADNGKWYDAGGPFQANTKGGCYTDIGPIAPHYDRTQVIHHVVRTIV
Physico‐chemical
properties
protein length:389 AA
molecular weight:42896,5 Da
isoelectric point:9,39
hydropathy:-0,39
Representative Protein Details
Accession
3u8Hb
Protein name
3u8Hb
Sequence length
225 AA
Molecular weight
24685,86580 Da
Isoelectric point
9,66447
Sequence
NTGLLRKGDRGDDVKLLQHRLNILGWQLTEDGIWGVQTDSAVRGYQYRAGLTVDGIVGAKTRAALIRDAILARAAEMGAYMVKHKWHYKDTTYKAKDTWAATKALSKPGSSCSHFVSWVLQGVGLLVAGKRISHDNGKVTGTGNLLGCQVIQAGGKTWDKLPDLRPGDVCVWDSNLAIYAGNGKWYDAGGPFRSNTKDGRYTNIGPIAPYYDRTKPVYYLVRAKV
Other Proteins in cluster: phalp2_23979
Total (incl. this protein): 4 Avg length: 305,8 Avg pI: 9,41
Protein ID Length (AA) pI
3u8Hb 225 9,66447
3IePn 239 8,95377
A0A8S5N3I7 370 9,61077
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31451
3pidJ
 11 29,4% 221 1.075E-09
2 phalp2_33018
4k89Y
 16 26,9% 234 4.420E-05

Domains

Domains [InterPro]
PG_1
Representative sequence (used for alignment): 3u8Hb (225 AA)
Member sequence: A0A8S5TYG6 (389 AA)
1 225 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctDsE1
[NCBI] 		2825390 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015961 [NCBI]
CDS location
range 7903 -> 9072
strand -
CDS
ATGAAGGAAGGAGGAGTGGACGAAAGGATGAAAATCAGCGAAAAGGGCTTGTCCATGATCGAGCGCTTTGAGGGCTGTTTGCTGAAAGCATCTAACAAGCTGGATGGTGTATGGACAATCGGTTATGGTCAGACCGGCAGCTACTACGGCAAACGGGTGCGCCGGGGAATGACCACAACGAAGGCTCTGGCGCACGCCTGGCTCCGTGACCACAGCATCAAGACCTACGAGGATGCGGTGACCCAGGCGGTCAAGGTGCCGCTGAACCAGAACCAGTTTGATGCCCTGGTGAGCTTTGCGTATAACGTGGGCGTTGGTGCGCTCAAGCAGTCCACCACCTTGCGCAAGCTGAATGCCGGCGACTACGCCGGTGCGGCGGACGCCCTGACCATGTGGACGAAATGCAAAGGCAAGGTGCTGGCTGGCCTGGTGCGGCGGCGGAAGGAAGAACGGGCCTTGTTTCTGACGCCCGTAACACAGGCCAAAACCACCAACACCGACCTGCTCCGCAAGGGCGACAGGGGCGATGACGTCAAGCTGCTCCAACACCGGCTGAACATCCTGGGCTGGCAGCTGACGGAGGACGGCATCTGGGGCGTGAAGACGGACACCGCCGTGCGGAACTATCAGTACCACGCCGATCTGACCGTGGACGGCATTGTAGGCCCCAAGACCCAGGCGGCGCTCATCAAGGATGCGATCCTGGCACGTGCGGCGGAAATGGGAGCATACATGGTGAAGCACAAGTGGCATTACCAGGATAAAACCTATCGCGCAAAATCCACCTTTGCTGCCACGAAAGCGCTGGACAAGCCCGGCAGCAGCTGCTCGCACTATGTGTCGTGGGTACTCCAGGACGTCGGCCTGTTGGAGTCCGGCAAACGCATCAGCCATGACAATGGCAAGGTGACTGGCACCGGTAATCTGATTGGTTGTCAGGTCATCCAGGCAGGCGGCAAGACCTGGGACAAGCTGTCCGACCTGCGGCCTGGTGACGTGTGCGTGTGGGACAGCAACCTAGCTATCTATGCCGACAATGGCAAATGGTATGATGCAGGCGGGCCGTTCCAGGCCAATACCAAGGGCGGTTGTTACACCGACATCGGTCCTATCGCCCCTCACTATGATCGCACCCAGGTAATACATCATGTGGTACGAACGATAGTGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3u8Hb) rather than this protein.
PDB ID
3u8Hb
Method AlphaFoldv2
Resolution 95.08
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50