Protein

Protein accession
A0A8S5QMT8 [UniProt]
Representative
3fQk2
Source
UniProt (cluster: phalp2_40316)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MHISSQGIALIQNYEGLRTTAYKPLKKESGWTIGYGHQGPDVKPGMVCTEQWAYEQLKRDLRQVEHQLISALNADEIEVTQGQFDALCSLLFNLSGGILRLVKFKLWAKLKAGDVKGAANEFLDISKAGGQEVRGLTLRRSAEARLFLS
Physico‐chemical
properties
protein length:149 AA
molecular weight:16547,8 Da
isoelectric point:8,91
hydropathy:-0,24
Representative Protein Details
Accession
3fQk2
Protein name
3fQk2
Sequence length
233 AA
Molecular weight
25882,21550 Da
Isoelectric point
9,45011
Sequence
MKTSTKGLNLIKKYEGLRLTAYKPVKTEKYWTIGYGHYGADVSEGMTITKQKAEEYLKKDVQSSENAVTKIGKEFNQNQFDALVSFTYNCGSKNLKTLCNGRTVEEIGDAITLYNKAGGKVLSGLVKRRAEEQKLYKKAVSTKKTEEAESIQNGKEESKVEEKKDDSFKVKVSINNLNIRKGPGKNYDKTGKFTGAGVFTIIEKKDGDGSKSGWGKLKSGLGWISLDFCEVVK
Other Proteins in cluster: phalp2_40316
Total (incl. this protein): 50 Avg length: 229,2 Avg pI: 8,96
Protein ID Length (AA) pI
3fQk2 233 9,45011
19lTk 220 9,66151
1gFiY 311 9,31989
24CLG 187 9,39538
2VkXI 258 9,63617
3TNjE 236 9,61838
3Zuq6 187 9,39538
3cx2W 265 8,29394
3fRVz 203 8,19859
3fTJW 235 9,41756
3mwap 227 9,70360
3s8GT 247 9,63262
3uZ5D 237 9,68007
3wDcl 239 9,77452
3wm2n 227 9,70360
3wq6T 240 9,82783
3xywq 237 9,58060
3yp6a 227 9,84176
3ywV5 227 9,74776
40cFS 201 5,45878
41n5Y 187 9,35483
4koym 235 9,41756
4lDvQ 256 6,38486
4lHua 255 8,65632
5QrKs 227 9,79102
5ZCc9 227 9,79102
5i1xX 196 9,89237
61Yzj 216 9,72752
622Bq 215 9,63991
65kpG 227 6,75414
66b5N 227 8,43790
67EHt 227 9,67305
68rYs 219 9,68820
6DTc2 205 9,25097
6UKaR 247 9,44251
6glvN 228 9,76350
6h2Ik 253 4,83907
6n0aj 227 9,74776
6oF28 233 5,85109
6pEpF 240 9,82841
6uH12 227 9,77523
6xxu 245 9,60581
7MHh3 227 9,81733
7QIS9 253 4,85896
7wFyG 206 9,48751
81Lri 250 9,42645
81NHB 237 9,71463
8fjF1 250 9,70289
8k3fP 227 5,35386
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33124
4MhZ3
 118 45,8% 229 5.533E-73
2 phalp2_17145
2TusA
 116 54,4% 147 9.622E-66
3 phalp2_23833
1mogV
 302 55,4% 148 2.232E-64
4 phalp2_33932
23JqA
 85 41,1% 253 2.232E-64
5 phalp2_34307
3A2Hz
 178 56,3% 158 2.261E-58
6 phalp2_33221
5jbqV
 447 44,5% 157 3.439E-53
7 phalp2_28113
7zmZV
 50 39,0% 228 1.085E-51
8 phalp2_16385
5LDDR
 25 52,9% 153 2.033E-51
9 phalp2_2498
5GMvl
 297 44,2% 147 4.683E-50
10 phalp2_24016
7V0GL
 4 45,7% 153 1.474E-48

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 3fQk2 (233 AA)
Member sequence: A0A8S5QMT8 (149 AA)
1 233 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctJ3t72
[NCBI] 		2826240 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015698 [NCBI]
CDS location
range 26112 -> 26561
strand -
CDS
ATGCACATAAGTAGTCAAGGCATCGCTCTTATTCAGAACTACGAAGGGCTGAGAACTACAGCCTATAAGCCGCTTAAGAAAGAATCCGGTTGGACAATCGGTTACGGTCATCAGGGTCCAGACGTAAAGCCTGGCATGGTATGTACTGAACAGTGGGCGTATGAGCAGCTAAAGCGAGATTTAAGACAAGTTGAGCATCAGCTTATCTCAGCGCTAAACGCAGATGAGATTGAAGTCACACAGGGTCAGTTCGATGCGCTGTGTTCTTTACTGTTCAACCTGTCAGGCGGAATACTCAGATTGGTGAAATTCAAACTCTGGGCAAAGCTCAAAGCTGGCGACGTTAAAGGCGCTGCGAATGAGTTTCTTGATATCAGCAAAGCAGGCGGACAAGAAGTCCGAGGCTTAACCCTCCGCAGAAGCGCTGAAGCCCGACTTTTCCTATCATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3fQk2) rather than this protein.
PDB ID
3fQk2
Method AlphaFoldv2
Resolution 87.93
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50